TLCD4 and TMEM229B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TLCD4	TMEM229B
Description		TLC domain containing 4	transmembrane protein 229B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane	Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Lipid Homeostasis	Response To Bacterium Macrophage Activation
Pathways
Drugs
Diseases
GWAS			Basophil percentage of white cells ( 32888494) Glomerular filtration rate in chronic kidney disease ( 26420894) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 28892059) Refractive error ( 32231278) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352)
Interacting Genes		72 interacting genes: ADGRB3 ADGRE2 ARV1 ATP13A1 BNIP3 CACNG1 CCDC167 CDIPT CFTR CHPT1 CLCN7 CLEC7A CMTM5 COMT CTXN3 CXCL16 CYP4F2 CYP4F22 DHRSX EBP EMC6 EMP1 ERG28 FA2H FDFT1 FXYD6 FXYD6-FXYD2 GJB2 GOSR2 GYPA HMOX1 IGFBP5 KRT1 LNPEP MS4A13 MYG1 NAT8 NDUFA3 NINJ1 NKG7 ORMDL1 PMP22 PRAF2 PRRT2 REEP6 SCAMP5 SCD SEC22A SEC22B SERP1 SFXN1 SFXN3 SLC41A1 SLC67A1 SMAGP STATH STX12 SYNDIG1 SYNJ2BP TIMM23 TMEM115 TMEM120B TMEM19 TMEM229B TMEM237 TMEM60 TMIE TVP23B UBE2J1 VEZT YIPF1 YIPF4	43 interacting genes: ACBD5 AQP6 ARL13B BIK CD53 CD79A CPLX4 CREB3L1 EBP ERGIC3 FAM209A FFAR2 FKBP7 GORAB GPX8 HSD17B13 ITGAM LHFPL5 MFF MGST3 MMGT1 MUC1 MYG1 NCR1 NEMP1 PANX1 PIGP PKMYT1 PVR REEP4 SEC22B SLC10A6 SLC39A2 SLC71A2 SYT2 TLCD4 TMEM14B TMEM35A TMEM45B TMPRSS2 TSNARE1 VAPA VSIR
Entrez ID		148534	161145
HPRD ID		08110	08157
Ensembl ID		ENSG00000152078	ENSG00000198133
Uniprot IDs		Q96MV1	Q8NBD8
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sterol Biosynthetic Process Lipid Biosynthetic Process Cholesterol Biosynthetic Process SNAP Receptor Activity Steroid Biosynthetic Process Membrane Fusion Serine Import Into Mitochondrion Lipid Metabolic Process Sterol Metabolic Process Cholesterol Transport Establishment Of Protein Localization Sterol Transport Membrane Organization Organic Cation Transport Import Into The Mitochondrion Protein Transport L-serine Transmembrane Transporter Activity L-serine Transport Protein Binding Bleb Assembly Serine Transport Vesicle Fusion	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane
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