ADORA2A and ACTN1

Number of citations of the paper that reports this interaction (PMID 12837758)
17

Data Source:
HPRD (in vitro, two hybrid)

		ADORA2A	ACTN1
Gene Name		adenosine A2a receptor	actinin, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane	Stress Fiber Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Fascia Adherens Focal Adhesion Z Disc Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Dendritic Spine Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Adenosine Receptor Activity Protein Binding Enzyme Binding Identical Protein Binding	Double-stranded RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Vinculin Binding Protein Domain Specific Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Ion Channel Binding Actin Filament Binding
	Biological Process	Adenosine Receptor Signaling Pathway CAMP Biosynthetic Process Phagocytosis Apoptotic Process Inflammatory Response Cellular Defense Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Central Nervous System Development Blood Coagulation Sensory Perception Blood Circulation Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway	Platelet Degranulation Blood Coagulation Platelet Activation Extracellular Matrix Organization Cell Junction Assembly Regulation Of Apoptotic Process Focal Adhesion Assembly Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Actin Crosslink Formation Regulation Of Nucleic Acid-templated Transcription
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Signalling by NGF G alpha (s) signalling events Nucleotide-like (purinergic) receptors Activation of TRKA receptors Class A/1 (Rhodopsin-like receptors) NGF signalling via TRKA from the plasma membrane Metabolic disorders of biological oxidation enzymes GPCR ligand binding GPCR downstream signaling NGF-independant TRKA activation Adenosine P1 receptors	Cell junction organization Syndecan interactions Response to elevated platelet cytosolic Ca2+ Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Nephrin interactions Platelet degranulation Non-integrin membrane-ECM interactions Platelet activation, signaling and aggregation Cell-extracellular matrix interactions
Drugs		Caffeine Theophylline Mefloquine Adenosine Dyphylline Pentoxifylline Oxtriphylline Theobromine Defibrotide Regadenoson 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol
Diseases
GWAS			Prostate cancer ( 23535732) Smoking behavior ( 19247474)
Protein-Protein Interactions		8 interactors: ACTN1 ACTN2 ACTN3 ACTN4 ADA CYTH2 DRD2 NAMPT	70 interactors: ACTN3 ADORA2A APC ATXN2 ATXN7 CACNA1A CAMK2A CDK5 CDK5R1 CDK5R2 CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 EPM2AIP1 ERBB2IP FBP1 FXN GFI1B GIPC1 GIT2 GRIA4 GRIN2A GTF2H1 ITGB1 KAT2B KCTD6 KPNA2 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SLC2A4 SORBS2 SPERT SRC SSX2IP TES TTN VCL XRCC4 ZYX
Entrez ID		135	87
HPRD ID		00043	00020
Ensembl ID		ENSG00000128271	ENSG00000072110
Uniprot IDs		A8K1F6 B3KVQ4 P29274	P12814
PDB IDs		1MMH 1UPE 2YDO 2YDV 3EML 3PWH 3QAK 3REY 3RFM 3UZA 3UZC 3VG9 3VGA 4EIY	2EYI 2EYN
Enriched GO Terms of Interacting Partners?		Protein Localization To Tight Junction Focal Adhesion Assembly Cell Junction Assembly Adherens Junction Assembly Cell-cell Junction Organization Cell-substrate Junction Assembly Negative Regulation Of Cellular Component Movement Secretion Actin Filament-based Process Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Platelet Degranulation Protein Localization To Cell Junction Adherens Junction Organization Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Actin Crosslink Formation Negative Regulation Of Circadian Rhythm Cell-matrix Adhesion Regulation Of Body Fluid Levels Platelet Activation Positive Regulation Of Ion Transport Cell-substrate Adhesion Vesicle-mediated Transport Muscle Contraction Regulation Of Apoptotic Process Cell Activation Regulation Of Cellular Component Movement Response To Wounding Actin-myosin Filament Sliding Muscle Filament Sliding Regulation Of Cell Death Muscle System Process Negative Regulation Of Transporter Activity Response To Morphine Actin-mediated Cell Contraction Response To Hypoxia Tight Junction Assembly Negative Regulation Of Ion Transmembrane Transport Positive Regulation Of Ion Transmembrane Transporter Activity Negative Regulation Of Transmembrane Transport Cellular Component Assembly Exocytosis Positive Regulation Of Transporter Activity Regulation Of Potassium Ion Transport Actin Filament Bundle Assembly Actin Filament-based Movement Regulation Of Sodium Ion Transport Negative Regulation Of Transport Apical Junction Assembly	Cytoskeleton Organization Cell Adhesion Cellular Component Assembly Organelle Organization Cell Development Regulation Of Protein Kinase Activity Actin Filament-based Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Actin Cytoskeleton Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Cell-substrate Adhesion Anatomical Structure Morphogenesis Neurogenesis Regulation Of Phosphorus Metabolic Process Cell Differentiation Generation Of Neurons Cell Morphogenesis Regulation Of Protein Phosphorylation Response To Stress Actomyosin Structure Organization Neuron Development Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Catalytic Activity Central Nervous System Development Positive Regulation Of Transferase Activity Regulation Of Signaling Response To Stimulus Response To Wounding Regulation Of Phosphorylation Cell-cell Junction Organization Regulation Of Cell Projection Organization Nervous System Development Anatomical Structure Formation Involved In Morphogenesis Single Organismal Cell-cell Adhesion Adherens Junction Organization Neuron Projection Development Neuron Differentiation Anatomical Structure Development Blood Coagulation Cell Surface Receptor Signaling Pathway Cell Projection Organization Hemostasis Cell-matrix Adhesion Apical Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signal Transduction Regulation Of Cell Death Regulation Of Neuron Projection Development
Tagcloud ?		aetio aetiological aetiology amygdala aversive avoid behaviours biologics corticoidism darpp drd2 electroshocks escape fatigue fear fearfulness helplessness hyper manipulations neuropsychiatry paradigm psychopathologies psychosocial socially stressed stressful treadmill uncontrollable wounding	b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc
Tagcloud (Difference) ?		aetio aetiological aetiology amygdala aversive avoid behaviours biologics corticoidism darpp drd2 electroshocks escape fatigue fear fearfulness helplessness hyper manipulations neuropsychiatry paradigm psychopathologies psychosocial socially stressed stressful treadmill uncontrollable wounding	b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc
Tagcloud (Intersection) ?