ADORA2A and ACTN1

Number of citations of the paper that reports this interaction (PubMedID 12837758)
0

Data Source:
HPRD (two hybrid, in vitro)

		ADORA2A	ACTN1
Description		adenosine A2a receptor	actinin alpha 1
Image
GO Annotations	Cellular Component	Intermediate Filament Plasma Membrane Membrane Axon Dendrite Axolemma Asymmetric Synapse Presynaptic Membrane Neuronal Cell Body Postsynaptic Membrane Presynaptic Active Zone Glutamatergic Synapse	Stress Fiber Ruffle Extracellular Region Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Brush Border Cell-cell Junction Fascia Adherens Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Z Disc Cell Junction Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Synapse Extracellular Exosome Anchoring Junction Glutamatergic Synapse
	Molecular Function	G Protein-coupled Adenosine Receptor Activity G Protein-coupled Receptor Activity Protein Binding Calmodulin Binding Lipid Binding Enzyme Binding Type 5 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Alpha-actinin Binding	Transcription Coactivator Activity Double-stranded RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Vinculin Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding Structural Constituent Of Postsynapse
	Biological Process	Synaptic Transmission, Dopaminergic G Protein-coupled Adenosine Receptor Signaling Pathway Response To Amphetamine Regulation Of DNA-templated Transcription Phagocytosis Apoptotic Process Inflammatory Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Synaptic Transmission, Cholinergic Central Nervous System Development Blood Coagulation Sensory Perception Locomotory Behavior Blood Circulation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Glutamate Secretion Positive Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Norepinephrine Secretion Response To Purine-containing Compound Response To Caffeine Positive Regulation Of Synaptic Transmission, GABAergic Synaptic Transmission, Glutamatergic Positive Regulation Of Urine Volume Vasodilation Eating Behavior Negative Regulation Of Vascular Permeability Response To Alkaloid Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Alpha-beta T Cell Activation Astrocyte Activation Neuron Projection Morphogenesis Positive Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response Regulation Of Mitochondrial Membrane Potential Membrane Depolarization Regulation Of Calcium Ion Transport Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Prepulse Inhibition Positive Regulation Of ERK1 And ERK2 Cascade Apoptotic Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Apoptotic Signaling Pathway	Actin Filament Organization Actin Cytoskeleton Organization Platelet Activation Platelet Formation Platelet Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Focal Adhesion Assembly Anatomical Structure Formation Involved In Morphogenesis Actin Filament Bundle Assembly Actin Filament Network Formation Muscle Cell Development Platelet Aggregation Postsynapse Organization
Pathways		NGF-independant TRKA activation Adenosine P1 receptors G alpha (s) signalling events Surfactant metabolism	Platelet degranulation Syndecan interactions Nephrin family interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components RHOD GTPase cycle RHOBTB2 GTPase cycle RHOF GTPase cycle
Drugs		Caffeine Theophylline Mefloquine Lamotrigine Adenosine Dyphylline Pentoxifylline Enprofylline Oxtriphylline Theobromine Binodenoson Defibrotide Apadenoson Atl146e Regadenoson 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol Doxofylline Istradefylline 8-chlorotheophylline KW-6356	Human calcitonin Copper
Diseases
GWAS		Acne (severe) ( 24927181) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Coffee consumption (cups per day) ( 31217584) Coronary artery disease ( 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Severity of nausea and vomiting of pregnancy ( 29563502)	Asthma ( 31959851) Cognitive decline rate in late mild cognitive impairment ( 26252872) Feeling fed-up ( 29500382) Feeling hurt ( 29500382) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) High light scatter reticulocyte count ( 32888494) Lack of perseverance ( 30718321) Mean platelet volume ( 27863252 32888494) Medication use (drugs used in diabetes) ( 31015401) Mosquito bite size ( 28199695) Neurociticism ( 29500382) Periodontitis (Mean PAL) ( 24024966) Platelet count ( 29403010 26805783 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Prostate cancer ( 23535732) Rheumatoid arthritis (ACPA-positive) ( 23143596) Smoking behavior ( 19247474) Urinary albumin excretion ( 30220432)
Interacting Genes		25 interacting genes: ACTN1 ACTN2 ACTN3 ACTN4 ADA BET1 CD4 CHN1 CNR1 CYTH2 DRD2 GPR37 HNRNPH3 HRH3 NAMPT NECAB2 PDHB POMZP3 PPM1J RHBDD2 SLC25A39 SLC4A1AP SNCA SPNS1 SYNGR1	93 interacting genes: ACTN3 ADORA2A APC APPBP2 ATXN2 ATXN7 CACNA1A CAMK2A CBY2 CDK5 CDK5R1 CDK5R2 CEBPA CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 DDIAS DSCAM DYNLT1 EIF2S1 EPM2AIP1 ERBIN FBP1 FILNC1 FXN FXR1 GADD45G GFI1B GIPC1 GIT2 GRIA4 GRIN2A GRM5 GTF2H1 HSPB1 ICAM5 ITGB1 KAT2B KCTD6 KPNA2 LINC01554 LNX1 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MTDH MTNR1A MTNR1B MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NKAPD1 NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SIRPA SLC2A4 SORBS2 SRC SSX2IP SYNPO2L TES TSC1 TTN TXN USP2 VCL XRCC4 ZYX
Entrez ID		135	87
HPRD ID		00043	00020
Ensembl ID		ENSG00000128271	ENSG00000072110
Uniprot IDs		A8K1F6 B3KVQ4 P29274 X5DNB4	A0A024R694 A0A7I2V4Y4 A0A804HL31 A0A804HLF4 H9KV75 P12814
PDB IDs		2YDO 2YDV 3EML 3PWH 3QAK 3REY 3RFM 3UZA 3UZC 3VG9 3VGA 4EIY 4UG2 4UHR 5G53 5IU4 5IU7 5IU8 5IUA 5IUB 5JTB 5K2A 5K2B 5K2C 5K2D 5MZJ 5MZP 5N2R 5NLX 5NM2 5NM4 5OLG 5OLH 5OLO 5OLV 5OLZ 5OM1 5OM4 5UIG 5UVI 5VRA 5WF5 5WF6 6AQF 6GDG 6GT3 6JZH 6LPJ 6LPK 6LPL 6MH8 6PS7 6S0L 6S0Q 6WQA 6ZDR 6ZDV 7ARO 7EZC 7PX4 7PYR 7RM5 7T32 8A2O 8A2P 8C9W 8CIC 8CU6 8CU7 8DU3 8GNE 8GNG 8JWY 8JWZ 8PWN 8RQQ 8RVW 8RW0 8RW4 8RW7 8RWC 8RWD 8RWE 8RWH 8RWI 8RWX 8UGW 8WDT 9FUP	2EYI 2EYN 2N8Y 2N8Z
Enriched GO Terms of Interacting Partners?		Pseudopodium Cortical Actin Cytoskeleton Cell Junction Peptidyltransferase Activity Leukotriene-C(4) Hydrolase Synapse Actin Cytoskeleton Plasma Membrane Focal Adhesion Assembly Positive Regulation Of MAPK Cascade Phenol-containing Compound Metabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of ERK1 And ERK2 Cascade Dopamine Metabolic Process Muscle Cell Development Response To Iron Ion Leukotriene C4 Gamma-glutamyl Transferase Activity Cell-substrate Junction Assembly Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Cell-substrate Junction Organization Presynapse Catecholamine Metabolic Process Glutathione Hydrolase Activity Leukotriene D4 Biosynthetic Process Fascia Adherens Negative Regulation Of Oxidative Phosphorylation Regulation Of Dopamine Uptake Involved In Synaptic Transmission Calcium Ion Binding Transmembrane Transporter Binding Focal Adhesion Z Disc Cell Junction Assembly Negative Regulation Of Cellular Respiration Glutathione Catabolic Process Dopamine Biosynthetic Process Postsynaptic Actin Cytoskeleton Regulation Of Intracellular Signal Transduction Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Glutathione Metabolic Process Positive Regulation Of Intracellular Signal Transduction Integrin Binding Sarcomere Cell Junction Organization Response To Inactivity Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Regulation Of Neuronal Synaptic Plasticity Catecholamine Uptake	Z Disc Cell Adhesion Cytoplasm Actin Binding Actin Cytoskeleton Actinin Binding Actin Cytoskeleton Organization Telethonin Binding Anchoring Junction Actomyosin Structure Organization Actin Filament-based Process Cell-cell Adhesion Cytoskeleton Organization Sarcomere Organization Structural Constituent Of Muscle Focal Adhesion Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Stress Fiber Cell Junction Organization Cell Projection Protein Kinase 5 Complex Cell-substrate Adhesion Regulation Of Protein Localization Regulation Of Programmed Cell Death Muscle Alpha-actinin Binding Negative Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Dendritic Spine FATZ Binding Regulation Of Apoptotic Process Cell-matrix Adhesion Regulation Of Multicellular Organismal Process Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Cell Communication Protein Binding Negative Regulation Of Signaling Neuronal Cell Body Synaptic Transmission, Glutamatergic Regulation Of Intracellular Signal Transduction Detection Of Muscle Stretch Organelle Organization Protein Kinase Binding Positive Regulation Of Apoptotic Process Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Regulation Of Generation Of Precursor Metabolites And Energy Cadherin Binding Cellular Response To Amyloid-beta
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