ADORA2A and NAMPT

Number of citations of the paper that reports this interaction (PMID 18486613)
4

Data Source:
BioGRID (two hybrid)

		ADORA2A	NAMPT
Gene Name		adenosine A2a receptor	nicotinamide phosphoribosyltransferase
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane	Extracellular Space Nucleus Cytosol Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Adenosine Receptor Activity Protein Binding Enzyme Binding Identical Protein Binding	Nicotinate-nucleotide Diphosphorylase (carboxylating) Activity Cytokine Activity Protein Binding Drug Binding Protein Homodimerization Activity Nicotinamide Phosphoribosyltransferase Activity
	Biological Process	Adenosine Receptor Signaling Pathway CAMP Biosynthetic Process Phagocytosis Apoptotic Process Inflammatory Response Cellular Defense Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Central Nervous System Development Blood Coagulation Sensory Perception Blood Circulation Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Nicotinamide Metabolic Process Signal Transduction Cell-cell Signaling Female Pregnancy Circadian Rhythm Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway NAD Biosynthetic Process Response To Organic Cyclic Compound NAD Metabolic Process Circadian Regulation Of Gene Expression Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Adipose Tissue Development
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Signalling by NGF G alpha (s) signalling events Nucleotide-like (purinergic) receptors Activation of TRKA receptors Class A/1 (Rhodopsin-like receptors) NGF signalling via TRKA from the plasma membrane Metabolic disorders of biological oxidation enzymes GPCR ligand binding GPCR downstream signaling NGF-independant TRKA activation Adenosine P1 receptors	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Nicotinamide salvaging Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia BMAL1:CLOCK,NPAS2 activates circadian gene expression Nicotinate metabolism Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs		Caffeine Theophylline Mefloquine Adenosine Dyphylline Pentoxifylline Oxtriphylline Theobromine Defibrotide Regadenoson 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ACTN1 ACTN2 ACTN3 ACTN4 ADA CYTH2 DRD2 NAMPT	4 interactors: ADORA2A AKT2 FANCA GGT1
Entrez ID		135	10135
HPRD ID		00043	09938
Ensembl ID		ENSG00000128271	ENSG00000105835
Uniprot IDs		A8K1F6 B3KVQ4 P29274	P43490
PDB IDs		1MMH 1UPE 2YDO 2YDV 3EML 3PWH 3QAK 3REY 3RFM 3UZA 3UZC 3VG9 3VGA 4EIY	2E5B 2E5C 2E5D 2GVG 2GVJ 3DGR 3DHD 3DHF 3DKJ 3DKL 4JNM 4JR5 4KFN 4KFO 4KFP 4LV9 4LVA 4LVB 4LVD 4LVF 4LVG 4M6P 4M6Q
Enriched GO Terms of Interacting Partners?		Protein Localization To Tight Junction Focal Adhesion Assembly Cell Junction Assembly Adherens Junction Assembly Cell-cell Junction Organization Cell-substrate Junction Assembly Negative Regulation Of Cellular Component Movement Secretion Actin Filament-based Process Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Platelet Degranulation Protein Localization To Cell Junction Adherens Junction Organization Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Actin Crosslink Formation Negative Regulation Of Circadian Rhythm Cell-matrix Adhesion Regulation Of Body Fluid Levels Platelet Activation Positive Regulation Of Ion Transport Cell-substrate Adhesion Vesicle-mediated Transport Muscle Contraction Regulation Of Apoptotic Process Cell Activation Regulation Of Cellular Component Movement Response To Wounding Actin-myosin Filament Sliding Muscle Filament Sliding Regulation Of Cell Death Muscle System Process Negative Regulation Of Transporter Activity Response To Morphine Actin-mediated Cell Contraction Response To Hypoxia Tight Junction Assembly Negative Regulation Of Ion Transmembrane Transport Positive Regulation Of Ion Transmembrane Transporter Activity Negative Regulation Of Transmembrane Transport Cellular Component Assembly Exocytosis Positive Regulation Of Transporter Activity Regulation Of Potassium Ion Transport Actin Filament Bundle Assembly Actin Filament-based Movement Regulation Of Sodium Ion Transport Negative Regulation Of Transport Apical Junction Assembly	Glutathione Catabolic Process Activation Of Ral GTPase Activity Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Cysteine Biosynthetic Process Positive Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Ral GTPase Activity Regulation Of Ral Protein Signal Transduction Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Cysteine Metabolic Process Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Fatty Acid Beta-oxidation Adenosine Receptor Signaling Pathway Positive Regulation Of Vesicle Fusion Peptide Catabolic Process Positive Regulation Of Glycogen Biosynthetic Process Peripheral Nervous System Myelin Maintenance Positive Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Beta-oxidation Cellular Modified Amino Acid Catabolic Process Sulfur Amino Acid Biosynthetic Process CAMP Biosynthetic Process Mammary Gland Epithelial Cell Differentiation Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Lipid Transport Myelin Maintenance Leukotriene Biosynthetic Process Glutathione Biosynthetic Process Glutathione Derivative Biosynthetic Process Glutamate Metabolic Process Positive Regulation Of Lipid Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Glycogen Biosynthetic Process Regulation Of Vesicle Fusion Activation Of Adenylate Cyclase Activity Peptide Biosynthetic Process Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Transport Leukotriene Metabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Glucose Import Cellular Response To Stimulus Myelination In Peripheral Nervous System CAMP Metabolic Process Regulation Of Glycogen Metabolic Process Cellular Polysaccharide Biosynthetic Process Positive Regulation Of Glucose Transport
Tagcloud ?		aetio aetiological aetiology amygdala aversive avoid behaviours biologics corticoidism darpp drd2 electroshocks escape fatigue fear fearfulness helplessness hyper manipulations neuropsychiatry paradigm psychopathologies psychosocial socially stressed stressful treadmill uncontrollable wounding	atp attribute autophagy concurrent connect deacetylases deacetylate depleted depletion driven fail gne illustrates inability k40 k9 limiting lose metabolite motility nad oncology oncosis predominant regenerate reveals slower tubulin utilize
Tagcloud (Difference) ?		aetio aetiological aetiology amygdala aversive avoid behaviours biologics corticoidism darpp drd2 electroshocks escape fatigue fear fearfulness helplessness hyper manipulations neuropsychiatry paradigm psychopathologies psychosocial socially stressed stressful treadmill uncontrollable wounding	atp attribute autophagy concurrent connect deacetylases deacetylate depleted depletion driven fail gne illustrates inability k40 k9 limiting lose metabolite motility nad oncology oncosis predominant regenerate reveals slower tubulin utilize
Tagcloud (Intersection) ?