ADORA2A and RHBDD2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		ADORA2A	RHBDD2
Description		adenosine A2a receptor	rhomboid domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Intermediate Filament Plasma Membrane Membrane Axon Dendrite Axolemma Asymmetric Synapse Presynaptic Membrane Neuronal Cell Body Postsynaptic Membrane Presynaptic Active Zone Glutamatergic Synapse	Golgi Membrane Nucleoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	G Protein-coupled Adenosine Receptor Activity G Protein-coupled Receptor Activity Protein Binding Calmodulin Binding Lipid Binding Enzyme Binding Type 5 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Alpha-actinin Binding	Serine-type Endopeptidase Activity Signal Recognition Particle Binding Protein Binding
	Biological Process	Synaptic Transmission, Dopaminergic G Protein-coupled Adenosine Receptor Signaling Pathway Response To Amphetamine Regulation Of DNA-templated Transcription Phagocytosis Apoptotic Process Inflammatory Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Synaptic Transmission, Cholinergic Central Nervous System Development Blood Coagulation Sensory Perception Locomotory Behavior Blood Circulation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Glutamate Secretion Positive Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Norepinephrine Secretion Response To Purine-containing Compound Response To Caffeine Positive Regulation Of Synaptic Transmission, GABAergic Synaptic Transmission, Glutamatergic Positive Regulation Of Urine Volume Vasodilation Eating Behavior Negative Regulation Of Vascular Permeability Response To Alkaloid Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Alpha-beta T Cell Activation Astrocyte Activation Neuron Projection Morphogenesis Positive Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response Regulation Of Mitochondrial Membrane Potential Membrane Depolarization Regulation Of Calcium Ion Transport Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Prepulse Inhibition Positive Regulation Of ERK1 And ERK2 Cascade Apoptotic Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Apoptotic Signaling Pathway	Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway
Pathways		NGF-independant TRKA activation Adenosine P1 receptors G alpha (s) signalling events Surfactant metabolism
Drugs		Caffeine Theophylline Mefloquine Lamotrigine Adenosine Dyphylline Pentoxifylline Enprofylline Oxtriphylline Theobromine Binodenoson Defibrotide Apadenoson Atl146e Regadenoson 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol Doxofylline Istradefylline 8-chlorotheophylline KW-6356
Diseases
GWAS		Acne (severe) ( 24927181) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Coffee consumption (cups per day) ( 31217584) Coronary artery disease ( 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Severity of nausea and vomiting of pregnancy ( 29563502)	Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		25 interacting genes: ACTN1 ACTN2 ACTN3 ACTN4 ADA BET1 CD4 CHN1 CNR1 CYTH2 DRD2 GPR37 HNRNPH3 HRH3 NAMPT NECAB2 PDHB POMZP3 PPM1J RHBDD2 SLC25A39 SLC4A1AP SNCA SPNS1 SYNGR1	60 interacting genes: ABHD16A ACSF2 ADORA2A BCL2L1 BCL2L2 CCR9 CHRM4 CIAO2A CIDEB COL8A1 COMT DIABLO DRD2 DYNC1H1 ERBB2 FKBP8 FMO4 GAL3ST3 GCSH GDF5-AS1 H2BC3 H4C7 IFI27L1 IL32 LETMD1 LIG4 MAOB MICOS13 MIEF2 MLX MMRN2 MPC2 MRM1 MRPL35 MTERF3 MYG1 NAALAD2 NCBP2AS2 NEDD4 NFU1 NRM PBX3 PTAFR ROMO1 RSAD2 SCGB3A1 SDHD SLC25A2 SLC25A3 SLC71A3P SNPH SYT16 TEX44 THBD TIMM17B TPRG1 TSR1 TUFM USP30 YAP1
Entrez ID		135	57414
HPRD ID		00043	11492
Ensembl ID		ENSG00000128271	ENSG00000005486
Uniprot IDs		A8K1F6 B3KVQ4 P29274 X5DNB4	Q6NTF9
PDB IDs		2YDO 2YDV 3EML 3PWH 3QAK 3REY 3RFM 3UZA 3UZC 3VG9 3VGA 4EIY 4UG2 4UHR 5G53 5IU4 5IU7 5IU8 5IUA 5IUB 5JTB 5K2A 5K2B 5K2C 5K2D 5MZJ 5MZP 5N2R 5NLX 5NM2 5NM4 5OLG 5OLH 5OLO 5OLV 5OLZ 5OM1 5OM4 5UIG 5UVI 5VRA 5WF5 5WF6 6AQF 6GDG 6GT3 6JZH 6LPJ 6LPK 6LPL 6MH8 6PS7 6S0L 6S0Q 6WQA 6ZDR 6ZDV 7ARO 7EZC 7PX4 7PYR 7RM5 7T32 8A2O 8A2P 8C9W 8CIC 8CU6 8CU7 8DU3 8GNE 8GNG 8JWY 8JWZ 8PWN 8RQQ 8RVW 8RW0 8RW4 8RW7 8RWC 8RWD 8RWE 8RWH 8RWI 8RWX 8UGW 8WDT 9FUP
Enriched GO Terms of Interacting Partners?		Pseudopodium Cortical Actin Cytoskeleton Cell Junction Peptidyltransferase Activity Leukotriene-C(4) Hydrolase Synapse Actin Cytoskeleton Plasma Membrane Focal Adhesion Assembly Positive Regulation Of MAPK Cascade Phenol-containing Compound Metabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of ERK1 And ERK2 Cascade Dopamine Metabolic Process Muscle Cell Development Response To Iron Ion Leukotriene C4 Gamma-glutamyl Transferase Activity Cell-substrate Junction Assembly Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Cell-substrate Junction Organization Presynapse Catecholamine Metabolic Process Glutathione Hydrolase Activity Leukotriene D4 Biosynthetic Process Fascia Adherens Negative Regulation Of Oxidative Phosphorylation Regulation Of Dopamine Uptake Involved In Synaptic Transmission Calcium Ion Binding Transmembrane Transporter Binding Focal Adhesion Z Disc Cell Junction Assembly Negative Regulation Of Cellular Respiration Glutathione Catabolic Process Dopamine Biosynthetic Process Postsynaptic Actin Cytoskeleton Regulation Of Intracellular Signal Transduction Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Glutathione Metabolic Process Positive Regulation Of Intracellular Signal Transduction Integrin Binding Sarcomere Cell Junction Organization Response To Inactivity Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Regulation Of Neuronal Synaptic Plasticity Catecholamine Uptake	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Synaptic Transmission, Dopaminergic Mitochondrial Envelope Mitochondrion Organization Apoptotic Signaling Pathway Response To Amphetamine Dopamine Metabolic Process Response To Alkaloid Regulation Of Catecholamine Secretion Protein Binding Response To Amine Membrane Epithelial Cell Proliferation Mitochondrial Membrane Bcl-2 Family Protein Complex Intrinsic Apoptotic Signaling Pathway Mitochondrial Matrix Catecholamine Catabolic Process Catecholamine Metabolic Process Dopamine Catabolic Process Protein Localization To Mitochondrion
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?