ADORA2A and ACTN2

Number of citations of the paper that reports this interaction (PMID 12837758)
17

Data Source:
HPRD (in vitro)

		ADORA2A	ACTN2
Gene Name		adenosine A2a receptor	actinin, alpha 2
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane	Extracellular Region Cytosol Cytoskeleton Actin Filament Focal Adhesion Z Disc Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Dendritic Spine Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Adenosine Receptor Activity Protein Binding Enzyme Binding Identical Protein Binding	Integrin Binding Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle LIM Domain Binding Thyroid Hormone Receptor Coactivator Activity Titin Binding Identical Protein Binding Ion Channel Binding Protein Dimerization Activity Actin Filament Binding FATZ Binding Titin Z Domain Binding
	Biological Process	Adenosine Receptor Signaling Pathway CAMP Biosynthetic Process Phagocytosis Apoptotic Process Inflammatory Response Cellular Defense Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Central Nervous System Development Blood Coagulation Sensory Perception Blood Circulation Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway	Platelet Degranulation Cell Adhesion Synaptic Transmission Blood Coagulation Microspike Assembly Muscle Filament Sliding Platelet Activation Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Focal Adhesion Assembly Protein Homotetramerization Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Receptor Activity
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Signalling by NGF G alpha (s) signalling events Nucleotide-like (purinergic) receptors Activation of TRKA receptors Class A/1 (Rhodopsin-like receptors) NGF signalling via TRKA from the plasma membrane Metabolic disorders of biological oxidation enzymes GPCR ligand binding GPCR downstream signaling NGF-independant TRKA activation Adenosine P1 receptors	Striated Muscle Contraction Platelet degranulation CREB phosphorylation through the activation of Ras Activation of NMDA receptor upon glutamate binding and postsynaptic events Response to elevated platelet cytosolic Ca2+ CREB phosphorylation through the activation of CaMKII Nephrin interactions Platelet activation, signaling and aggregation Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Transmission across Chemical Synapses Post NMDA receptor activation events
Drugs		Caffeine Theophylline Mefloquine Adenosine Dyphylline Pentoxifylline Oxtriphylline Theobromine Defibrotide Regadenoson 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ACTN1 ACTN2 ACTN3 ACTN4 ADA CYTH2 DRD2 NAMPT	59 interactors: ACTN3 ADAM12 ADORA2A ANG ATXN2 ATXN7 BRMS1L CAMK2A CAMK2D CAMK2G CAPN1 COIL DISC1 DLG1 DLG4 EPS8L1 ERBB2IP FAM154A FBXL22 GRIN1 GRIN2B ITGB3BP KAT2B KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MED14 MICALL2 MOS MYOZ1 MYOZ2 MYOZ3 MYPN NCOA2 NCOR1 NOS3 NR1I2 NRIP1 PALLD PDLIM1 PDLIM3 PKD2 RAVER1 RPL35 RTP5 SELE SNAI1 SNW1 SP100 SSX2IP ST7 SYNPO2 TNN TTN UTRN ZNF446
Entrez ID		135	88
HPRD ID		00043	00019
Ensembl ID		ENSG00000128271	ENSG00000077522
Uniprot IDs		A8K1F6 B3KVQ4 P29274	B2RCS5 P35609 Q59FD9
PDB IDs		1MMH 1UPE 2YDO 2YDV 3EML 3PWH 3QAK 3REY 3RFM 3UZA 3UZC 3VG9 3VGA 4EIY	1H8B 1HCI 1QUU
Enriched GO Terms of Interacting Partners?		Protein Localization To Tight Junction Focal Adhesion Assembly Cell Junction Assembly Adherens Junction Assembly Cell-cell Junction Organization Cell-substrate Junction Assembly Negative Regulation Of Cellular Component Movement Secretion Actin Filament-based Process Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Platelet Degranulation Protein Localization To Cell Junction Adherens Junction Organization Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Actin Crosslink Formation Negative Regulation Of Circadian Rhythm Cell-matrix Adhesion Regulation Of Body Fluid Levels Platelet Activation Positive Regulation Of Ion Transport Cell-substrate Adhesion Vesicle-mediated Transport Muscle Contraction Regulation Of Apoptotic Process Cell Activation Regulation Of Cellular Component Movement Response To Wounding Actin-myosin Filament Sliding Muscle Filament Sliding Regulation Of Cell Death Muscle System Process Negative Regulation Of Transporter Activity Response To Morphine Actin-mediated Cell Contraction Response To Hypoxia Tight Junction Assembly Negative Regulation Of Ion Transmembrane Transport Positive Regulation Of Ion Transmembrane Transporter Activity Negative Regulation Of Transmembrane Transport Cellular Component Assembly Exocytosis Positive Regulation Of Transporter Activity Regulation Of Potassium Ion Transport Actin Filament Bundle Assembly Actin Filament-based Movement Regulation Of Sodium Ion Transport Negative Regulation Of Transport Apical Junction Assembly	Cytoskeleton Organization Regulation Of Ion Transport Organelle Organization Cell Communication Actin Filament-based Process Signaling Cellular Component Assembly Positive Regulation Of Cellular Metabolic Process Regulation Of Ion Transmembrane Transport Anatomical Structure Development Synaptic Transmission Positive Regulation Of Metabolic Process Cell Development Signal Transduction Movement Of Cell Or Subcellular Component Cell Differentiation Cell-cell Signaling Regulation Of Cellular Process Rhythmic Process Developmental Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Actin Cytoskeleton Organization Anatomical Structure Morphogenesis Protein Complex Assembly Regulation Of Potassium Ion Transport Striated Muscle Cell Differentiation Regulation Of Signaling Anatomical Structure Formation Involved In Morphogenesis Response To Organic Substance Regulation Of Sodium Ion Transport Response To Abiotic Stimulus Muscle System Process Negative Regulation Of Transport Striated Muscle Cell Development Positive Regulation Of Cellular Biosynthetic Process Myofibril Assembly Establishment Or Maintenance Of Apical/basal Cell Polarity Transcription Initiation From RNA Polymerase II Promoter Cell Adhesion Muscle Cell Development Cellular Calcium Ion Homeostasis Regulation Of Receptor Internalization Regulation Of Cellular Response To Heat Response To Stimulus Regulation Of Histone Deacetylase Activity Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Locomotion Negative Regulation Of Ion Transport
Tagcloud ?		aetio aetiological aetiology amygdala aversive avoid behaviours biologics corticoidism darpp drd2 electroshocks escape fatigue fear fearfulness helplessness hyper manipulations neuropsychiatry paradigm psychopathologies psychosocial socially stressed stressful treadmill uncontrollable wounding	actinin barr cd99 cdk8 dnajb2 e2f e2f2 ebv epstein fatigue hsp40 hybridized indicative infectious infective irritability isg20 malaise microarrays mononucleosis oligonucleotides pbmc persist pilot recovered resolve somnolence spotted uneventfully
Tagcloud (Difference) ?		aetio aetiological aetiology amygdala aversive avoid behaviours biologics corticoidism darpp drd2 electroshocks escape fear fearfulness helplessness hyper manipulations neuropsychiatry paradigm psychopathologies psychosocial socially stressed stressful treadmill uncontrollable wounding	actinin barr cd99 cdk8 dnajb2 e2f e2f2 ebv epstein hsp40 hybridized indicative infectious infective irritability isg20 malaise microarrays mononucleosis oligonucleotides pbmc persist pilot recovered resolve somnolence spotted uneventfully
Tagcloud (Intersection) ?		fatigue