COL10A1 and MESD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		COL10A1	MESD
Description		collagen type X alpha 1 chain	mesoderm development LRP chaperone
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type X Trimer Endoplasmic Reticulum Lumen Extracellular Matrix	Endoplasmic Reticulum Plasma Membrane
	Molecular Function	Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Metal Ion Binding	Protein Binding Identical Protein Binding Protein Folding Chaperone Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Skeletal System Development	Ossification Protein Folding Phagocytosis Mesoderm Development Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Protein Localization To Cell Surface Protein Localization To Plasma Membrane Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Pathways		Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Non-integrin membrane-ECM interactions Collagen chain trimerization
Drugs
Diseases		Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
GWAS		Age-related macular degeneration ( 21665990 23455636) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Myopia ( 27182965) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		10 interacting genes: ANXA5 BANP CIDEB MESD NRF1 P4HB SGTB UBQLN1 UBQLN2 VSNL1	78 interacting genes: - ABCG8 ABITRAM ACBD7 AKIRIN2 AKNAD1 AKT1 APP ARB2A ASH2L ATP6V1E1 ATP6V1E2 BORCS8 BORCS8-MEF2B BRD4 C17orf75 CDR2L CENATAC CENPH CHCHD1 CLP1 CNOT9 COL10A1 COL1A2 COX14 COX5A CUTC CYP4F11 DDX6 ENKD1 FAM13C FARS2 FCER1A GEM GOLGA7 GPKOW GTPBP3 H2AB2 H2AB3 HSBP1L1 IGF1 KLHL20 KPNB1 LCE1A LRP5 LY96 MAGEB4 MAP1LC3B MAPDA MCM9 MELTF MKNK2 MRM1 MTNR1A NAA35 NRDE2 PMF1 PSMA5 QARS1 RCOR3 RFC3 SLC6A20 SMARCB1 SNX5 SNX7 TEKTL1 TEX12 TEX48 TPM2 TREX2 TRMT2A TTC21A TTC23 TYMP UBQLN1 ZNF493 ZNF827 ZNF844
Entrez ID		1300	23184
HPRD ID		00357	12129
Ensembl ID		ENSG00000123500	ENSG00000117899
Uniprot IDs		A0A650AXN9 Q03692	Q14696
PDB IDs		1GR3
Enriched GO Terms of Interacting Partners?		Response To Endoplasmic Reticulum Stress Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Identical Protein Binding Positive Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of ERAD Pathway Negative Regulation Of Store-operated Calcium Channel Activity Endothelial Microparticle Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Procollagen-proline 4-dioxygenase Complex Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Negative Regulation Of G Protein-coupled Receptor Internalization TRC Complex Negative Regulation Of Transport Autophagosome Organization Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Peptidyl-proline Hydroxylation Negative Regulation Of Clathrin-dependent Endocytosis Procollagen-proline 4-dioxygenase Activity Cellular Response To Hypoxia Lipid Droplet Fusion Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Response To Decreased Oxygen Levels	Protein Binding Proton-transporting Two-sector ATPase Complex, Catalytic Domain
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