COL10A1 and ANXA5

Number of citations of the paper that reports this interaction (PMID 1397263)
11

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		COL10A1	ANXA5
Gene Name		collagen, type X, alpha 1	annexin A5
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Collagen Trimer Endoplasmic Reticulum Lumen Cell Cortex	Intracellular Cytoplasm Focal Adhesion External Side Of Plasma Membrane Membrane Extracellular Vesicular Exosome Endothelial Microparticle
	Molecular Function	Metal Ion Binding	Phospholipase Inhibitor Activity Calcium Ion Binding Phospholipid Binding Calcium-dependent Phospholipid Binding
	Biological Process	Skeletal System Development Endochondral Ossification Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Cartilage Development	Signal Transduction Blood Coagulation Response To Organic Substance Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Coagulation
Pathways		Collagen formation Collagen degradation Integrin cell surface interactions Non-integrin membrane-ECM interactions Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23455636 21665990)	Chronic obstructive pulmonary disease ( 21685187)
Protein-Protein Interactions		4 interactors: ANXA5 BANP P4HB UBQLN1	17 interactors: ACTG1 APP COL10A1 COL2A1 EED EIF4G1 FDFT1 IFNGR2 ITGB5 KDR LAMC3 PPP2R1B SUPT4H1 TERF1 TERF2 TERF2IP TINF2
Entrez ID		1300	308
HPRD ID		00357	00568
Ensembl ID		ENSG00000123500	ENSG00000164111
Uniprot IDs		Q03692	P08758
PDB IDs		1GR3	1ANW 1ANX 1AVH 1AVR 1HAK 1HVD 1HVE 1HVF 1HVG 1SAV 2XO2 2XO3
Enriched GO Terms of Interacting Partners?		Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Oxidative Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Process Response To Hypoxia Regulation Of Cell Death Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline 4-hydroxyproline Metabolic Process Peptidyl-proline Hydroxylation Protein Hydroxylation	Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Protein Localization To Chromosome, Telomeric Region Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomerase Extracellular Matrix Organization Extracellular Structure Organization Telomere Maintenance Regulation Of Chromosome Organization Negative Regulation Of Chromosome Organization RNA-dependent DNA Replication Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Metabolic Process Protein Localization To Chromosome Telomeric Loop Formation Age-dependent Telomere Shortening Homeostatic Process Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere Telomere Capping Negative Regulation Of DNA Replication Negative Regulation Of Telomere Maintenance Via Telomerase Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Chromosome Organization Regulation Of DNA Replication Anatomical Structure Morphogenesis Positive Regulation Of Organelle Organization Tissue Homeostasis Regulation Of Organelle Organization Negative Regulation Of Cellular Metabolic Process Endochondral Ossification Multicellular Organismal Homeostasis Organelle Organization Chromatin Modification Negative Regulation Of Protein ADP-ribosylation Negative Regulation Of DNA Recombination At Telomere DNA Replication Collagen Catabolic Process Cell Development Cell Aging Chromatin Organization Cell Morphogenesis Involved In Differentiation Collagen Metabolic Process Regulation Of Protein ADP-ribosylation Synaptic Growth At Neuromuscular Junction Developmental Process MRNA 3'-end Processing
Tagcloud ?		agc aggrecan biocompatibility biomechanical chondrocyte coating compressive cooh engineering fn functionalization functionalized hydrogels laden modulus nanocomposite nanocomposites nanotubes peg pellet reinforcement scaffolds swnt swnts tensile tolerate ultimate	a2 alkaline altered annexin annexins anxa2 bglap col1a1 else fibrinolysis generate ibsp knock knockdown mineralizing osteoblasts osteogenesis osteogenic osteoprogenitor programming psiren rafts responsiveness runx2 shrna si stat6 vesicles
Tagcloud (Difference) ?		agc aggrecan biocompatibility biomechanical chondrocyte coating compressive cooh engineering fn functionalization functionalized hydrogels laden modulus nanocomposite nanocomposites nanotubes peg pellet reinforcement scaffolds swnt swnts tensile tolerate ultimate	a2 alkaline altered annexin annexins anxa2 bglap else fibrinolysis generate ibsp knock knockdown mineralizing osteoblasts osteogenesis osteogenic osteoprogenitor programming psiren rafts responsiveness runx2 shrna si stat6 vesicles
Tagcloud (Intersection) ?		col1a1