SHKBP1 and CUL3

Number of citations of the paper that reports this interaction (PMID 21145461)
61

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		SHKBP1	CUL3
Gene Name		SH3KBP1 binding protein 1	cullin 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Golgi Membrane Nucleoplasm Polar Microtubule Cytosol Membrane Cul3-RING Ubiquitin Ligase Complex Extracellular Vesicular Exosome
	Molecular Function		Ubiquitin-protein Transferase Activity Protein Binding Cyclin Binding POZ Domain Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Protein Homooligomerization	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Trophectodermal Cellular Morphogenesis Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Cell Cycle Arrest Mitotic Metaphase Plate Congression Integrin-mediated Signaling Pathway Gastrulation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Positive Regulation Of Cell Proliferation Wnt Signaling Pathway Cell Migration Protein Ubiquitination Stem Cell Division Positive Regulation Of Cytokinesis Negative Regulation Of Rho Protein Signal Transduction Embryonic Cleavage Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway
Pathways			Antigen processing: Ubiquitination & Proteasome degradation misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Hedgehog degradation of DVL Class I MHC mediated antigen processing & presentation Signaling by WNT in cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CCNG1 COL7A1 CUL3 GRB2 PIN1 SH3KBP1 YWHAG	54 interactors: ABTB1 ABTB2 APP ARHGEF12 BTBD10 CAMK1D CAND1 CCND1 CCNE1 CDC25A CDC34 COMMD1 DCUN1D1 DCUN1D4 DYRK4 EFNB1 FOLR1 GMCL1 GPS1 HLA-DMB HSF2 KCTD13 KCTD5 KCTD6 KCTD9 KLHL12 KLHL2 KLHL20 KLHL3 KLHL42 KLHL5 NEDD8 OLIG2 PDIA2 RBX1 RCBTB1 RCBTB2 RHOBTB3 RIT1 RNF7 SHKBP1 SUMO2 SUMO3 TCEB1 TNFAIP1 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2M WNT7B ZMAT4
Entrez ID		92799	8452
HPRD ID		15338	09123
Ensembl ID		ENSG00000160410	ENSG00000036257
Uniprot IDs		Q8TBC3	B7Z600 Q13618
PDB IDs			4AP2 4APF 4EOZ 4HXI
Enriched GO Terms of Interacting Partners?		Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Organization Regulation Of Organelle Organization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Regulation Of Protein Metabolic Process Regulation Of Cytokinesis Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Negative Regulation Of Phosphorylation Positive Regulation Of Organelle Organization Regulation Of Mitotic Cell Cycle Regulation Of Catalytic Activity Negative Regulation Of Signaling Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Cell Cycle Regulation Of Signal Transduction Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Mitotic Nuclear Division Regulation Of Signaling Embryonic Morphogenesis Negative Regulation Of Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Process Trophectodermal Cellular Morphogenesis Regulation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Mitotic Cell Cycle ERBB Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Gastrulation Response To Organonitrogen Compound Cell Migration Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Negative Regulation Of Protein Metabolic Process Cellular Response To Insulin Stimulus Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Cell Motility Regulation Of Cell Cycle Negative Regulation Of Kinase Activity Apoptotic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Cell Division	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K48-linked Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Neddylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Protein Monoubiquitination Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Protein Homooligomerization Protein K11-linked Ubiquitination Proteolysis Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Catabolic Process ISG15-protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein Oligomerization Response To Growth Factor Regulation Of Cellular Process Protein Complex Assembly DNA Replication Cellular Response To Stress Positive Regulation Of Cellular Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle MyD88-independent Toll-like Receptor Signaling Pathway
Tagcloud ?		assembled bottlenecks built capability connected decisions discriminatory distinguish evaluations executes incomplete inflamome interplay mi micrornas modules motivate network nevertheless organized specialized tend traf2 traffic translated ubc uncovered validations verification	besides bioactive bioinformatics btb btbd3 candidate connectivity degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases ltbp1 microrna micrornas nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2
Tagcloud (Difference) ?		assembled bottlenecks built capability connected decisions discriminatory distinguish evaluations executes incomplete inflamome interplay mi modules motivate network nevertheless organized specialized tend traf2 traffic translated ubc uncovered validations verification	besides bioactive bioinformatics btb btbd3 candidate connectivity degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases ltbp1 microrna nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2
Tagcloud (Intersection) ?		micrornas