SHKBP1 and SH3KBP1

Number of citations of the paper that reports this interaction (PMID 11152963)
11

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SHKBP1	SH3KBP1
Gene Name		SH3KBP1 binding protein 1	SH3-domain kinase binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Cytoplasmic Vesicle Membrane Neuron Projection Synapse
	Molecular Function		Protein Binding SH3 Domain Binding
	Biological Process	Protein Homooligomerization	Endocytosis Apoptotic Process Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Cell Migration Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CCNG1 COL7A1 CUL3 GRB2 PIN1 SH3KBP1 YWHAG	45 interactors: ABI2 ARAP1 ARHGAP27 ASAP1 ASAP2 BCAR1 BLNK BMPR1B CAPZA1 CBL CBLB CD2 GRB2 HCK INPP5D ITSN2 LMNA MVB12A NEDD4 PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 PSMA3 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SUMO1 SUMO2 SUMO3 SYNJ1 TAF6 TJP2 UBB UBC ZBTB7B ZNF219
Entrez ID		92799	30011
HPRD ID		15338	02301
Ensembl ID		ENSG00000160410	ENSG00000147010
Uniprot IDs		Q8TBC3	B7Z6E8 Q5JPT6 Q96B97
PDB IDs			2BZ8 2K6D 2K9G 2O2O 2YDL
Enriched GO Terms of Interacting Partners?		Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Organization Regulation Of Organelle Organization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Regulation Of Protein Metabolic Process Regulation Of Cytokinesis Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Negative Regulation Of Phosphorylation Positive Regulation Of Organelle Organization Regulation Of Mitotic Cell Cycle Regulation Of Catalytic Activity Negative Regulation Of Signaling Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Cell Cycle Regulation Of Signal Transduction Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Mitotic Nuclear Division Regulation Of Signaling Embryonic Morphogenesis Negative Regulation Of Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Process Trophectodermal Cellular Morphogenesis Regulation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Mitotic Cell Cycle ERBB Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Gastrulation Response To Organonitrogen Compound Cell Migration Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Negative Regulation Of Protein Metabolic Process Cellular Response To Insulin Stimulus Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Cell Motility Regulation Of Cell Cycle Negative Regulation Of Kinase Activity Apoptotic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Cell Division	Regulation Of Signal Transduction Regulation Of Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Cellular Process Signaling Signal Transduction Cell Communication Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Fibroblast Growth Factor Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Cell Death Antigen Receptor-mediated Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway Apoptotic Process Immune System Process Programmed Cell Death Cellular Response To Stimulus Cell Death Death Fc Receptor Signaling Pathway Immune Response Viral Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Endocytosis Locomotion Movement Of Cell Or Subcellular Component Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Catalytic Activity Regulation Of Immune Response
Tagcloud ?		assembled bottlenecks built capability connected decisions discriminatory distinguish evaluations executes incomplete inflamome interplay mi micrornas modules motivate network nevertheless organized specialized tend traf2 traffic translated ubc uncovered validations verification	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Difference) ?		assembled bottlenecks built capability connected decisions discriminatory distinguish evaluations executes incomplete inflamome interplay mi micrornas motivate network nevertheless organized specialized tend traf2 traffic translated ubc uncovered validations verification	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?		modules