NID1 and PLXDC1

Number of citations of the paper that reports this interaction (PubMedID 16574105)
0

Data Source:
HPRD (in vitro, in vivo)

		NID1	PLXDC1
Description		nidogen 1	plexin domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Matrix Extracellular Exosome Cell Periphery Protein Complex Involved In Cell-matrix Adhesion	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Bicellular Tight Junction Membrane Dendrite Neuronal Cell Body Receptor Complex Anchoring Junction
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Collagen Binding Laminin Binding Laminin-1 Binding Proteoglycan Binding Extracellular Matrix Binding	Protein Binding
	Biological Process	Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Glomerular Basement Membrane Development Positive Regulation Of Cell Adhesion Positive Regulation Of Muscle Cell Differentiation Basement Membrane Organization Regulation Of Basement Membrane Organization Positive Regulation Of Integrin-mediated Signaling Pathway	Angiogenesis Spinal Cord Development
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Laminin interactions Laminin interactions
Drugs		Urokinase
Diseases
GWAS		Cutaneous nevi ( 21478494) Diverticulitis ( 28585551) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Mean platelet volume ( 32888494) Response to levetiracetam in genetic generalized epilepsy ( 32308125) Urate levels in overweight individuals ( 25811787)	Asthma ( 31619474) Tau burden ( 33426524)
Interacting Genes		21 interacting genes: APP COL13A1 COL1A1 COL4A1 FBLN1 FBLN2 FGA FGB HSPG2 ITGAV ITGB3 LACRT LAMA1 LAMC1 LAMC2 LGALS3BP PLAU PLXDC1 PRELP PTPRF SKIL	4 interacting genes: C5AR2 GPR35 NID1 NRF1
Entrez ID		4811	57125
HPRD ID		00574	08439
Ensembl ID		ENSG00000116962	ENSG00000161381
Uniprot IDs		P14543	Q8IUK5
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Structural Constituent Extracellular Matrix Extracellular Region Basement Membrane Extracellular Space Blood Coagulation, Fibrin Clot Formation Regulation Of Cell Adhesion Cell Adhesion Regulation Of Cell-substrate Adhesion Protein Activation Cascade Cell-substrate Adhesion Positive Regulation Of Cell Adhesion Protein Complex Involved In Cell-matrix Adhesion Cell-matrix Adhesion Plasminogen Activation Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Signal Transduction Integrin Binding Regulation Of Substrate Adhesion-dependent Cell Spreading Extracellular Exosome Endoplasmic Reticulum Lumen Heparin Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Integrin Alphav-beta3 Complex Platelet Alpha Granule Fibrinolysis Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Integrin-mediated Signaling Pathway External Side Of Plasma Membrane Positive Regulation Of Cell Migration Extracellular Vesicle Positive Regulation Of Cell Motility Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-HMGB1 Complex Laminin-1 Complex Cell Adhesion Molecule Binding Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Fibronectin Binding Extracellular Matrix Binding Blood Coagulation Coagulation Alphav-beta3 Integrin-IGF-1-IGF1R Complex Hemostasis Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Cell Migration Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Structural Constituent Conferring Tensile Strength	C-X-C Chemokine Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Basement Membrane Organization Laminin-1 Binding Complement Component C5a Receptor Activity Complement Component C5a Signaling Pathway Negative Regulation Of Neutrophil Migration Complement Receptor Activity Negative Regulation Of Neutrophil Chemotaxis Protein Complex Involved In Cell-matrix Adhesion G Protein-coupled Receptor Activity Positive Regulation Of Integrin-mediated Signaling Pathway Proteoglycan Binding Glomerular Basement Membrane Development Complement Receptor Mediated Signaling Pathway Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Integrin-mediated Signaling Pathway Laminin Binding Negative Regulation Of Leukocyte Chemotaxis Chemokine Receptor Activity Negative Regulation Of Transporter Activity
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