NID1 and LAMC1

Number of citations of the paper that reports this interaction (PubMedID 9733643)
0

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		NID1	LAMC1
Description		nidogen 1	laminin subunit gamma 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Matrix Extracellular Exosome Cell Periphery Protein Complex Involved In Cell-matrix Adhesion	Extracellular Region Basement Membrane Laminin-1 Complex Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Laminin-10 Complex Laminin-11 Complex Extracellular Exosome Protein Complex Involved In Cell-matrix Adhesion
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Collagen Binding Laminin Binding Laminin-1 Binding Proteoglycan Binding Extracellular Matrix Binding	Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity
	Biological Process	Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Glomerular Basement Membrane Development Positive Regulation Of Cell Adhesion Positive Regulation Of Muscle Cell Differentiation Basement Membrane Organization Regulation Of Basement Membrane Organization Positive Regulation Of Integrin-mediated Signaling Pathway	Cell Adhesion Endoderm Development Tissue Development Cell Migration Extracellular Matrix Disassembly Hemidesmosome Assembly Substrate Adhesion-dependent Cell Spreading Maintenance Of Blood-brain Barrier Positive Regulation Of Cell Adhesion Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Muscle Cell Differentiation Protein-containing Complex Assembly Regulation Of Basement Membrane Organization Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Laminin interactions Laminin interactions	Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation EGR2 and SOX10-mediated initiation of Schwann cell myelination Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Drugs		Urokinase	Lanoteplase
Diseases
GWAS		Cutaneous nevi ( 21478494) Diverticulitis ( 28585551) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Mean platelet volume ( 32888494) Response to levetiracetam in genetic generalized epilepsy ( 32308125) Urate levels in overweight individuals ( 25811787)	Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Clozapine-induced agranulocytosis ( 25187353) Colorectal cancer ( 23266556) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 30224653) Fuchs's corneal dystrophy ( 28358029) HDL cholesterol levels ( 32203549) Height ( 31562340) Hemoglobin ( 32888494) Hypertriglyceridemia ( 27599772) LDL cholesterol levels in HIV infection ( 33109212) Red blood cell count ( 32888494) Systemic lupus erythematosus ( 24871463)
Interacting Genes		21 interacting genes: APP COL13A1 COL1A1 COL4A1 FBLN1 FBLN2 FGA FGB HSPG2 ITGAV ITGB3 LACRT LAMA1 LAMC1 LAMC2 LGALS3BP PLAU PLXDC1 PRELP PTPRF SKIL	17 interacting genes: ANTXR2 APP ATF7IP CENPU FILNC1 KEAP1 LAMA5 NID1 NID2 SMARCA2 SNAPIN SNX2 SRPK1 TANK UBC WASHC3 WEE2-AS1
Entrez ID		4811	3915
HPRD ID		00574	01030
Ensembl ID		ENSG00000116962	ENSG00000135862
Uniprot IDs		P14543	P11047 Q6NVY8
PDB IDs			5XAU 7CEC 8DMK
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Structural Constituent Extracellular Matrix Extracellular Region Basement Membrane Extracellular Space Blood Coagulation, Fibrin Clot Formation Regulation Of Cell Adhesion Cell Adhesion Regulation Of Cell-substrate Adhesion Protein Activation Cascade Cell-substrate Adhesion Positive Regulation Of Cell Adhesion Protein Complex Involved In Cell-matrix Adhesion Cell-matrix Adhesion Plasminogen Activation Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Signal Transduction Integrin Binding Regulation Of Substrate Adhesion-dependent Cell Spreading Extracellular Exosome Endoplasmic Reticulum Lumen Heparin Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Integrin Alphav-beta3 Complex Platelet Alpha Granule Fibrinolysis Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Integrin-mediated Signaling Pathway External Side Of Plasma Membrane Positive Regulation Of Cell Migration Extracellular Vesicle Positive Regulation Of Cell Motility Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-HMGB1 Complex Laminin-1 Complex Cell Adhesion Molecule Binding Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Fibronectin Binding Extracellular Matrix Binding Blood Coagulation Coagulation Alphav-beta3 Integrin-IGF-1-IGF1R Complex Hemostasis Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Cell Migration Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Structural Constituent Conferring Tensile Strength	Extracellular Matrix Organization Extracellular Structure Organization Basement Membrane Extracellular Matrix Structural Constituent Insulin Receptor Binding
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