NID1

Description		nidogen 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Matrix Extracellular Exosome Cell Periphery Protein Complex Involved In Cell-matrix Adhesion
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Collagen Binding Laminin Binding Laminin-1 Binding Proteoglycan Binding Extracellular Matrix Binding
	Biological Process	Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Glomerular Basement Membrane Development Positive Regulation Of Cell Adhesion Positive Regulation Of Muscle Cell Differentiation Basement Membrane Organization Regulation Of Basement Membrane Organization Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Laminin interactions Laminin interactions
Drugs		Urokinase
Diseases
GWAS		Cutaneous nevi ( 21478494) Diverticulitis ( 28585551) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Mean platelet volume ( 32888494) Response to levetiracetam in genetic generalized epilepsy ( 32308125) Urate levels in overweight individuals ( 25811787)
Interacting Genes		21 interacting genes: APP COL13A1 COL1A1 COL4A1 FBLN1 FBLN2 FGA FGB HSPG2 ITGAV ITGB3 LACRT LAMA1 LAMC1 LAMC2 LGALS3BP PLAU PLXDC1 PRELP PTPRF SKIL
Entrez ID		4811
HPRD ID		00574
Ensembl ID		ENSG00000116962
Uniprot IDs		P14543
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Structural Constituent Extracellular Matrix Extracellular Region Basement Membrane Extracellular Space Blood Coagulation, Fibrin Clot Formation Regulation Of Cell Adhesion Cell Adhesion Regulation Of Cell-substrate Adhesion Protein Activation Cascade Cell-substrate Adhesion Positive Regulation Of Cell Adhesion Protein Complex Involved In Cell-matrix Adhesion Cell-matrix Adhesion Plasminogen Activation Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Signal Transduction Integrin Binding Regulation Of Substrate Adhesion-dependent Cell Spreading Extracellular Exosome Endoplasmic Reticulum Lumen Heparin Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Integrin Alphav-beta3 Complex Platelet Alpha Granule Fibrinolysis Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Integrin-mediated Signaling Pathway External Side Of Plasma Membrane Positive Regulation Of Cell Migration Extracellular Vesicle Positive Regulation Of Cell Motility Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-HMGB1 Complex Laminin-1 Complex Cell Adhesion Molecule Binding Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Fibronectin Binding Extracellular Matrix Binding Blood Coagulation Coagulation Alphav-beta3 Integrin-IGF-1-IGF1R Complex Hemostasis Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Cell Migration Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Structural Constituent Conferring Tensile Strength
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