NID1 and PRELP

Number of citations of the paper that reports this interaction (PMID 11847210)
16

Data Source:
HPRD (in vitro)

		NID1	PRELP
Gene Name		nidogen 1	proline/arginine-rich end leucine-rich repeat protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Basal Lamina Extracellular Matrix Extracellular Vesicular Exosome Cell Periphery	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Extracellular Matrix Vesicle Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Collagen Binding Laminin Binding Laminin-1 Binding Proteoglycan Binding	Extracellular Matrix Structural Constituent Heparin Binding
	Biological Process	Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Glomerular Basement Membrane Development Basement Membrane Organization	Skeletal System Development Carbohydrate Metabolic Process Cell Aging Pathogenesis Keratan Sulfate Biosynthetic Process Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Keratan Sulfate Catabolic Process Small Molecule Metabolic Process
Pathways		Laminin interactions Degradation of the extracellular matrix	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome Keratan sulfate/keratin metabolism MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D MPS IIIC - Sanfilippo syndrome C Keratan sulfate biosynthesis Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Keratan sulfate degradation Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Metabolism of carbohydrates MPS VII - Sly syndrome MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Cutaneous nevi ( 21478494)
Protein-Protein Interactions		21 interactors: APP COL13A1 COL1A1 COL4A1 FBLN1 FBLN2 FGA FGB HSPG2 ITGAV ITGB3 LACRT LAMA1 LAMC1 LAMC2 LGALS3BP PLAU PLXDC1 PRELP PTPRF SKIL	7 interactors: COL1A1 COL2A1 FBLN2 FN1 HSPG2 NID1 NID2
Entrez ID		4811	5549
HPRD ID		00574	03556
Ensembl ID		ENSG00000116962	ENSG00000188783
Uniprot IDs		P14543	P51888
PDB IDs		1NDX
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Cell Adhesion Regulation Of Body Fluid Levels Cell-substrate Adhesion Blood Coagulation Hemostasis Blood Vessel Development Vasculature Development Cell-matrix Adhesion Platelet Degranulation Locomotion Wound Healing Chemotaxis Platelet Activation Regulation Of Cell-substrate Adhesion Regulation Of Cell Adhesion Axon Guidance Blood Vessel Morphogenesis Response To Wounding Anatomical Structure Morphogenesis Movement Of Cell Or Subcellular Component Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Axonogenesis Platelet Aggregation Cardiovascular System Development Tissue Development Retinal Blood Vessel Morphogenesis Endochondral Ossification Axon Development Substrate Adhesion-dependent Cell Spreading Angiogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Receptor Biosynthetic Process Apolipoprotein A-I-mediated Signaling Pathway Response To External Stimulus Positive Regulation Of Cell Morphogenesis Involved In Differentiation Cell-substrate Junction Assembly Neuron Projection Morphogenesis Vesicle-mediated Transport Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Anatomical Structure Formation Involved In Morphogenesis Developmental Process Collagen Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Morphogenesis Involved In Differentiation Negative Regulation Of Lipoprotein Metabolic Process Multicellular Organismal Development	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Cartilage Development Involved In Endochondral Bone Morphogenesis Endochondral Ossification Endochondral Bone Morphogenesis Bone Morphogenesis Embryonic Skeletal System Development Cell-matrix Adhesion Basement Membrane Organization Regulation Of Cell-substrate Adhesion Cartilage Development Cell-substrate Adhesion Bone Development Connective Tissue Development Skeletal System Morphogenesis Ossification Cardiovascular System Development Anatomical Structure Formation Involved In Morphogenesis Collagen Fibril Organization Collagen Catabolic Process Embryo Development Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Chondrocyte Differentiation Multicellular Organismal Metabolic Process Cellular Response To Fluoride Blood Vessel Development Vasculature Development Proteoglycan Metabolic Process Skeletal System Development Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Adhesion Tooth Eruption Response To Fluoride Embryonic Skeletal System Morphogenesis Embryonic Morphogenesis Tissue Development Sensory Perception Of Sound Positive Regulation Of Cell Morphogenesis Involved In Differentiation Visual Perception Calcium-independent Cell-matrix Adhesion Chordate Embryonic Development Sensory Perception Of Light Stimulus Embryo Development Ending In Birth Or Egg Hatching Sensory Perception Of Mechanical Stimulus Platelet Activation Cellular Response To Vitamin E Leukocyte Migration Organ Morphogenesis
Tagcloud ?		accordance biogenesis bound brains clip details enriched immunoprecipitation intron linking messenger mirna mirnas neurexin neurodegeneration neurodevelopmental neurological nrxn1 pirnas processed reexamine represses rnas seq srnas systematically tar tardbp tdp	abundance adenocarcinomas aversely clues die dismal ductal extend galectin lethal lgals1 pancreas pancreatic pdac personalized prolargin proteome proteomes rarely rps8 s8 sts survive survivors tgfbeta top upstream vegfa vlts
Tagcloud (Difference) ?		accordance biogenesis bound brains clip details enriched immunoprecipitation intron linking messenger mirna mirnas neurexin neurodegeneration neurodevelopmental neurological nrxn1 pirnas processed reexamine represses rnas seq srnas systematically tar tardbp tdp	abundance adenocarcinomas aversely clues die dismal ductal extend galectin lethal lgals1 pancreas pancreatic pdac personalized prolargin proteome proteomes rarely rps8 s8 sts survive survivors tgfbeta top upstream vegfa vlts
Tagcloud (Intersection) ?