COL3A1 and CAPN1

Number of citations of the paper that reports this interaction (PubMedID 12358155)
0

Data Source:
HPRD (two hybrid)

		COL3A1	CAPN1
Description		collagen type III alpha 1 chain	calpain 1
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type III Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix	Cornified Envelope Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Calpain Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Blood Vessel Development In Utero Embryonic Development Neuron Migration Tissue Homeostasis Chondrocyte Differentiation Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Heart Development Response To Radiation Gene Expression Peptide Cross-linking Layer Formation In Cerebral Cortex Cerebral Cortex Development Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Lung Development Transforming Growth Factor Beta1 Production Response To Cytokine Positive Regulation Of Rho Protein Signal Transduction Multicellular Organism Growth Aorta Development Limb Joint Morphogenesis Wound Healing Skin Development Fibroblast Proliferation Elastic Fiber Assembly Animal Organ Development Digestive Tract Development System Development Negative Regulation Of Immune Response Cartilage Development Endochondral Bone Morphogenesis Aorta Smooth Muscle Tissue Morphogenesis Cellular Response To Amino Acid Stimulus Basement Membrane Organization Supramolecular Fiber Organization Response To Angiotensin Negative Regulation Of Neuron Migration	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Receptor Catabolic Process Regulation Of Catalytic Activity Mammary Gland Involution Self Proteolysis NMDA Selective Glutamate Receptor Signaling Pathway
Pathways		Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization Developmental Lineage of Pancreatic Ductal Cells	Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		Collagenase clostridium histolyticum	4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness x smoking interaction ( 32117412) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Parkinson disease and lewy body pathology ( 25663231) Platelet distribution width ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Urate levels ( 31578528)
Interacting Genes		14 interacting genes: AP2B1 CAPN1 DDR1 DDR2 FGF7 HTRA1 MAG MYOC PCOLCE PDGFA PDGFB SPARC THBS1 VWF	55 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KCTD7 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLC22A1 SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM
Entrez ID		1281	823
HPRD ID		00365	00253
Ensembl ID		ENSG00000168542	ENSG00000014216
Uniprot IDs		A0AAG2UVC5 P02461	B2RDI5 B4DWH5 P07384
PDB IDs		2V53 3DMW 4AE2 4AEJ 4AK3 4GYX 6FZV 6FZW 7WWR 7WWS 7XAN	1ZCM 2ARY 7W7O 7X79 8GX3
Enriched GO Terms of Interacting Partners?		Collagen Binding Platelet Alpha Granule Lumen Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extracellular Space Extracellular Region Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Protein Tyrosine Kinase Collagen Receptor Activity Response To Wounding Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Platelet Alpha Granule Extracellular Matrix Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Extracellular Matrix Structural Constituent Regulation Of Body Fluid Levels Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phosphate Metabolic Process Regulation Of Wound Healing Regulation Of Cellular Component Organization Negative Regulation Of Phospholipid Biosynthetic Process Regulation Of Endothelial Cell Proliferation Animal Organ Development Regulation Of Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Cell Motility Regulation Of MAPK Cascade Regulation Of Response To Wounding Regulation Of Locomotion Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Signal Transduction Regulation Of Branching Involved In Salivary Gland Morphogenesis Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Phosphorylation Regulation Of Blood Coagulation Regulation Of Cell-substrate Adhesion Regulation Of Hemostasis Regulation Of Smooth Muscle Cell Migration Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Regulation Of Signal Transduction	Organelle Organization Regulation Of Programmed Cell Death Response To Alcohol Regulation Of Organelle Organization Regulation Of Apoptotic Process Identical Protein Binding Positive Regulation Of Organelle Organization Regulation Of Multicellular Organismal Process Protease Binding Cytoplasm Regulation Of Signal Transduction Regulation Of Cellular Component Organization Developmental Process Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Amino Acid Stimulus Positive Regulation Of Gene Expression Response To Lipid Positive Regulation Of Programmed Cell Death Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Hepatocyte Apoptotic Process Cytosol Regulation Of Actin Filament Depolymerization Negative Regulation Of Apoptotic Process Cell Junction Maintenance Regulation Of Renin Secretion Into Blood Stream Regulation Of Autophagy Sarcomere Negative Regulation Of Programmed Cell Death Regulation Of Actin Filament-based Process Regulation Of Mitochondrial Membrane Permeability G-protein Beta-subunit Binding Regulation Of Protein Localization Response To Amino Acid Release Of Cytochrome C From Mitochondria Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Fluoride Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Apoptotic Process Cellular Component Maintenance Regulation Of Membrane Permeability Cysteine-type Peptidase Activity Positive Regulation Of Cellular Component Organization Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Protein Localization
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