COL3A1 and PDGFB

Number of citations of the paper that reports this interaction (PubMedID 8900172)
0

Data Source:
BioGRID (pull down, far western blotting)

		COL3A1	PDGFB
Description		collagen type III alpha 1 chain	platelet derived growth factor subunit B
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type III Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix	Golgi Membrane Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Cell Surface Membrane Basolateral Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Platelet-derived Growth Factor Complex
	Molecular Function	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Platelet-derived Growth Factor Receptor Binding Protein Binding Collagen Binding Growth Factor Activity Superoxide-generating NADPH Oxidase Activator Activity Chemoattractant Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Receptor Ligand Activity Platelet-derived Growth Factor Binding
	Biological Process	Blood Vessel Development In Utero Embryonic Development Neuron Migration Tissue Homeostasis Chondrocyte Differentiation Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Heart Development Response To Radiation Gene Expression Peptide Cross-linking Layer Formation In Cerebral Cortex Cerebral Cortex Development Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Lung Development Transforming Growth Factor Beta1 Production Response To Cytokine Positive Regulation Of Rho Protein Signal Transduction Multicellular Organism Growth Aorta Development Limb Joint Morphogenesis Wound Healing Skin Development Fibroblast Proliferation Elastic Fiber Assembly Animal Organ Development Digestive Tract Development System Development Negative Regulation Of Immune Response Cartilage Development Endochondral Bone Morphogenesis Aorta Smooth Muscle Tissue Morphogenesis Cellular Response To Amino Acid Stimulus Basement Membrane Organization Supramolecular Fiber Organization Response To Angiotensin Negative Regulation Of Neuron Migration	Angiogenesis Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Monocyte Chemotaxis Positive Regulation Of Glomerular Filtration Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Heart Development Positive Regulation Of Cell Population Proliferation Response To Wounding Gene Expression Regulation Of Gene Expression Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Platelet Activation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Smooth Muscle Adaptation Positive Regulation Of Smooth Muscle Cell Migration Peptidyl-tyrosine Phosphorylation Hemopoiesis Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Intracellular Signal Transduction Interleukin-18-mediated Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Paracrine Signaling Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Mycophenolic Acid Positive Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Glomerular Mesangial Cell Development Reactive Oxygen Species Metabolic Process Positive Regulation Of Calcium Ion Import Positive Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Metanephric Mesenchymal Cell Migration
Pathways		Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization Developmental Lineage of Pancreatic Ductal Cells	Platelet degranulation PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer Non-integrin membrane-ECM interactions RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		Collagenase clostridium histolyticum	Pegpleranib
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)	Glioma Malignant pleural mesothelioma
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness x smoking interaction ( 32117412) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Parkinson disease and lewy body pathology ( 25663231) Platelet distribution width ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000)
Interacting Genes		14 interacting genes: AP2B1 CAPN1 DDR1 DDR2 FGF7 HTRA1 MAG MYOC PCOLCE PDGFA PDGFB SPARC THBS1 VWF	23 interacting genes: A2M ART1 BCCIP COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 FBXO7 HNRNPC HRAS HSPG2 LRP1 LYVE1 MDFI PDAP1 PDGFRA PDGFRB PIK3R1 SPARC THBS1
Entrez ID		1281	5155
HPRD ID		00365	01815
Ensembl ID		ENSG00000168542	ENSG00000100311
Uniprot IDs		A0AAG2UVC5 P02461	A0A384NYY3 P01127
PDB IDs		2V53 3DMW 4AE2 4AEJ 4AK3 4GYX 6FZV 6FZW 7WWR 7WWS 7XAN	1PDG 3MJG 4HQU 4HQX 4QCI 6T9E
Enriched GO Terms of Interacting Partners?		Collagen Binding Platelet Alpha Granule Lumen Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extracellular Space Extracellular Region Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Protein Tyrosine Kinase Collagen Receptor Activity Response To Wounding Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Platelet Alpha Granule Extracellular Matrix Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Extracellular Matrix Structural Constituent Regulation Of Body Fluid Levels Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phosphate Metabolic Process Regulation Of Wound Healing Regulation Of Cellular Component Organization Negative Regulation Of Phospholipid Biosynthetic Process Regulation Of Endothelial Cell Proliferation Animal Organ Development Regulation Of Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Cell Motility Regulation Of MAPK Cascade Regulation Of Response To Wounding Regulation Of Locomotion Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Signal Transduction Regulation Of Branching Involved In Salivary Gland Morphogenesis Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Phosphorylation Regulation Of Blood Coagulation Regulation Of Cell-substrate Adhesion Regulation Of Hemostasis Regulation Of Smooth Muscle Cell Migration Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Regulation Of Signal Transduction	Platelet-derived Growth Factor Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen Trimer Extracellular Matrix Fibrillar Collagen Trimer Extracellular Matrix Structural Constituent Basement Membrane Anatomical Structure Morphogenesis Endoplasmic Reticulum Lumen Collagen Fibril Organization Developmental Process Extracellular Matrix Organization Extracellular Structure Organization Cellular Response To Amino Acid Stimulus Phospholipase C Activator Activity Regulation Of Locomotion Response To Amino Acid Enzyme-linked Receptor Protein Signaling Pathway Animal Organ Morphogenesis Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Locomotion Anatomical Structure Formation Involved In Morphogenesis Angiogenesis Extracellular Region Protease Binding Proteoglycan Binding Skin Development Cell Differentiation Collagen Type I Trimer Collagen V Binding Cellular Developmental Process Collagen Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Kinase Regulator Activity Positive Regulation Of Smooth Muscle Cell Proliferation Extracellular Matrix Assembly Cell Surface Receptor Signaling Pathway Response To Wounding Vascular Endothelial Growth Factor Binding Basement Membrane Organization Blood Vessel Morphogenesis Cartilage Development Collagen Type XI Trimer Skeletal System Morphogenesis Cell Adhesion
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