COL3A1 and PDGFB

Number of citations of the paper that reports this interaction (PMID 8900172)
4

Data Source:
BioGRID (pull down, far western blotting)

		COL3A1	PDGFB
Gene Name		collagen, type III, alpha 1	platelet-derived growth factor beta polypeptide
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type III Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix	Golgi Membrane Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Cell Surface Basolateral Plasma Membrane Platelet Alpha Granule Lumen
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Platelet-derived Growth Factor Receptor Binding Protein Binding Collagen Binding Growth Factor Activity Superoxide-generating NADPH Oxidase Activator Activity Chemoattractant Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Platelet-derived Growth Factor Binding
	Biological Process	Skeletal System Development Receptor-mediated Endocytosis Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Heart Development Aging Response To Radiation Response To Mechanical Stimulus Peptide Cross-linking Cerebral Cortex Development Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Response To Cytokine Positive Regulation Of Rho Protein Signal Transduction Wound Healing Extracellular Fibril Organization Skin Development Digestive Tract Development Negative Regulation Of Immune Response Aorta Smooth Muscle Tissue Morphogenesis Cellular Response To Amino Acid Stimulus Negative Regulation Of Neuron Migration	Response To Hypoxia Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Monocyte Chemotaxis Platelet Degranulation Positive Regulation Of Glomerular Filtration DNA Replication Protein Phosphorylation Substrate-dependent Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Blood Coagulation Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Wounding Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Cell Growth Peptidyl-serine Phosphorylation Peptidyl-tyrosine Phosphorylation Cell Projection Assembly Actin Cytoskeleton Organization Hemopoiesis Platelet Activation Extracellular Matrix Organization Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Response To Estradiol Response To Insulin Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Paracrine Signaling Fc-epsilon Receptor Signaling Pathway Response To Drug Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of DNA Replication Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle, Embryonic Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Chemotaxis Cell Chemotaxis Branching Involved In Salivary Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Mycophenolic Acid Positive Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Glomerular Mesangial Cell Development Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Metanephric Glomerular Endothelium Development Reactive Oxygen Species Metabolic Process Positive Regulation Of Calcium Ion Import Positive Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Metanephric Mesenchymal Cell Migration
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Syndecan interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth Scavenging by Class A Receptors	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Platelet degranulation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Response to elevated platelet cytosolic Ca2+ Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Non-integrin membrane-ECM interactions Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: CAPN1 DDR1 DDR2 FGF7 HTRA1 MAG MYOC PCOLCE PDGFA PDGFB SPARC THBS1	20 interactors: A2M ART1 COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 HNRNPC HRAS HSPG2 LRP1 LYVE1 MDFI PDAP1 PDGFRA PDGFRB SPARC THBS1
Entrez ID		1281	5155
HPRD ID		00365	01815
Ensembl ID		ENSG00000168542	ENSG00000100311
Uniprot IDs		P02461	P01127
PDB IDs		2V53 3DMW 4AE2 4AEJ 4AK3 4GYX	1PDG 3MJG 4HQU 4HQX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Proliferation Regulation Of Cell Migration Regulation Of Cell Motility Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Response To Wounding Regulation Of Cellular Component Movement Regulation Of Cellular Component Organization Platelet Degranulation Organ Development Positive Regulation Of Epithelial Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Organ Morphogenesis Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Wound Healing Regulation Of Epithelial Cell Proliferation Response To Growth Factor Multicellular Organismal Development Negative Regulation Of Phosphatidylinositol Biosynthetic Process Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Secretion Regulation Of Epithelial Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Developmental Process ERBB Signaling Pathway Blood Coagulation Collagen-activated Signaling Pathway Negative Regulation Of Phospholipid Biosynthetic Process System Development Positive Regulation Of Cell Proliferation Hemostasis Platelet Activation Positive Regulation Of Endothelial Cell Migration Neurotrophin TRK Receptor Signaling Pathway Platelet-derived Growth Factor Receptor-beta Signaling Pathway Secretion By Cell Neurotrophin Signaling Pathway Bone Development Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Anatomical Structure Development Positive Regulation Of Protein Kinase B Signaling	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Cardiovascular System Development Multicellular Organismal Metabolic Process Response To Wounding Blood Vessel Development Vasculature Development Skeletal System Development Cellular Response To Amino Acid Stimulus Anatomical Structure Morphogenesis Wound Healing Organ Morphogenesis Response To External Stimulus Platelet Activation Movement Of Cell Or Subcellular Component Cellular Response To Growth Factor Stimulus Response To Amino Acid Developmental Process Response To Growth Factor Locomotion Blood Coagulation Hemostasis Skeletal System Morphogenesis Collagen Fibril Organization Heart Development Cellular Response To Acid Chemical Regulation Of Body Fluid Levels Regulation Of Cell Migration Chemotaxis Anatomical Structure Development Regulation Of Cell Motility Cartilage Development Involved In Endochondral Bone Morphogenesis Response To Stimulus Tissue Development System Development Endocytosis Blood Vessel Morphogenesis Connective Tissue Development Regulation Of Locomotion Regulation Of Cellular Component Movement Cellular Response To Organic Substance Organ Development Cellular Response To Organonitrogen Compound Ossification Protein Heterotrimerization Cellular Response To Stimulus
Tagcloud ?		abrogation adenomas alcoholic ccl3 col1a2 compromised confirming fibrotic fivefold gh ghr ghrld hepatic hyperlipidemia livers microscopic mup1 nafld proteomics qpcr selenbp2 socs2 socs3 steatosis superarray tgfbeta threefold tolerance unravel	5b alone angiogenesis associates aurora coexpression dataset ectopic effector glioblastomas glioma gliomas grade isoform latent mesenchymal modeled pn predominantly promoters proneural reveals shorter stat5 stat5b tcga transducer xl yielded
Tagcloud (Difference) ?		abrogation adenomas alcoholic ccl3 col1a2 compromised confirming fibrotic fivefold gh ghr ghrld hepatic hyperlipidemia livers microscopic mup1 nafld proteomics qpcr selenbp2 socs2 socs3 steatosis superarray tgfbeta threefold tolerance unravel	5b alone angiogenesis associates aurora coexpression dataset ectopic effector glioblastomas glioma gliomas grade isoform latent mesenchymal modeled pn predominantly promoters proneural reveals shorter stat5 stat5b tcga transducer xl yielded
Tagcloud (Intersection) ?