COL3A1 and DDR2

Number of citations of the paper that reports this interaction (PMID 9659899)
120

Data Source:
HPRD (in vitro)

		COL3A1	DDR2
Gene Name		collagen, type III, alpha 1	discoidin domain receptor tyrosine kinase 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type III Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Tyrosine Kinase Collagen Receptor Activity
	Biological Process	Skeletal System Development Receptor-mediated Endocytosis Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Heart Development Aging Response To Radiation Response To Mechanical Stimulus Peptide Cross-linking Cerebral Cortex Development Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Response To Cytokine Positive Regulation Of Rho Protein Signal Transduction Wound Healing Extracellular Fibril Organization Skin Development Digestive Tract Development Negative Regulation Of Immune Response Aorta Smooth Muscle Tissue Morphogenesis Cellular Response To Amino Acid Stimulus Negative Regulation Of Neuron Migration	Ossification Endochondral Bone Growth Cell Adhesion Signal Transduction Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Fibroblast Migration Peptidyl-tyrosine Phosphorylation Extracellular Matrix Organization Collagen Fibril Organization Regulation Of Bone Mineralization Biomineral Tissue Development Chondrocyte Proliferation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Protein Autophosphorylation Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Extracellular Matrix Disassembly
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Syndecan interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth Scavenging by Class A Receptors	Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: CAPN1 DDR1 DDR2 FGF7 HTRA1 MAG MYOC PCOLCE PDGFA PDGFB SPARC THBS1	4 interactors: COL1A1 COL3A1 SHC1 SRC
Entrez ID		1281	4921
HPRD ID		00365	01868
Ensembl ID		ENSG00000168542	ENSG00000162733
Uniprot IDs		P02461	Q16832
PDB IDs		2V53 3DMW 4AE2 4AEJ 4AK3 4GYX	2WUH 2Z4F
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Proliferation Regulation Of Cell Migration Regulation Of Cell Motility Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Response To Wounding Regulation Of Cellular Component Movement Regulation Of Cellular Component Organization Platelet Degranulation Organ Development Positive Regulation Of Epithelial Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Organ Morphogenesis Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Wound Healing Regulation Of Epithelial Cell Proliferation Response To Growth Factor Multicellular Organismal Development Negative Regulation Of Phosphatidylinositol Biosynthetic Process Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Secretion Regulation Of Epithelial Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Developmental Process ERBB Signaling Pathway Blood Coagulation Collagen-activated Signaling Pathway Negative Regulation Of Phospholipid Biosynthetic Process System Development Positive Regulation Of Cell Proliferation Hemostasis Platelet Activation Positive Regulation Of Endothelial Cell Migration Neurotrophin TRK Receptor Signaling Pathway Platelet-derived Growth Factor Receptor-beta Signaling Pathway Secretion By Cell Neurotrophin Signaling Pathway Bone Development Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Anatomical Structure Development Positive Regulation Of Protein Kinase B Signaling	Platelet Activation Blood Coagulation Hemostasis Cellular Response To Organonitrogen Compound Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Wound Healing Response To Growth Factor Cell Activation Response To Wounding Cellular Response To Acid Chemical Response To Organonitrogen Compound Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Response To Transforming Growth Factor Beta Response To Fibroblast Growth Factor Response To Mechanical Stimulus Leukocyte Migration Locomotion Positive Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Negative Regulation Of Cell-substrate Adhesion Response To Peptide Hormone Response To Peptide Cellular Response To Amino Acid Stimulus Blood Vessel Development Collagen Fibril Organization Cellular Response To Organic Substance Collagen Catabolic Process Vasculature Development Skeletal System Development Regulation Of Cell Migration Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Regulation Of Cell Motility Multicellular Organismal Metabolic Process Endocytosis Extracellular Matrix Disassembly Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Cytokine Anatomical Structure Morphogenesis Response To Organic Substance Response To Amino Acid Head Development Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Fluoride Integrin-mediated Signaling Pathway Response To Hydrogen Peroxide
Tagcloud ?		abrogation adenomas alcoholic ccl3 col1a2 compromised confirming fibrotic fivefold gh ghr ghrld hepatic hyperlipidemia livers microscopic mup1 nafld proteomics qpcr selenbp2 socs2 socs3 steatosis superarray tgfbeta threefold tolerance unravel	aacr adaptive adaptor compensatory conversely cotargeting dampen dasatinib driven emerged gab1 harboring igf1r implicating irs2 library met option overlaying panel phosphoproteomics py rationale res rescued rtk scc synergistic weakly
Tagcloud (Difference) ?		abrogation adenomas alcoholic ccl3 col1a2 compromised confirming fibrotic fivefold gh ghr ghrld hepatic hyperlipidemia livers microscopic mup1 nafld proteomics qpcr selenbp2 socs2 socs3 steatosis superarray tgfbeta threefold tolerance unravel	aacr adaptive adaptor compensatory conversely cotargeting dampen dasatinib driven emerged gab1 harboring igf1r implicating irs2 library met option overlaying panel phosphoproteomics py rationale res rescued rtk scc synergistic weakly
Tagcloud (Intersection) ?