KMT2D and SMAD1

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		KMT2D	SMAD1
Gene Name		lysine (K)-specific methyltransferase 2D	SMAD family member 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex	Intracellular Nucleus Nuclear Inner Membrane Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Integral Component Of Membrane Protein Complex
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Transcription Regulatory Region DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Receptor Signaling Protein Activity Protein Binding Protein Kinase Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Identical Protein Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding
	Biological Process	Oocyte Growth Chromatin Organization Chromatin Silencing Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Estrogen Positive Regulation Of Transcription From RNA Polymerase II Promoter Oogenesis Histone H3-K4 Methylation	MAPK Cascade Ureteric Bud Development Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Gamete Generation Negative Regulation Of Cell Proliferation Embryonic Pattern Specification Response To Organonitrogen Compound Positive Regulation Of Gene Expression Negative Regulation Of Muscle Cell Apoptotic Process BMP Signaling Pathway Midbrain Development Hindbrain Development Primary MiRNA Processing Wound Healing Response To Drug Homeostatic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Dendrite Morphogenesis Cartilage Development Cardiac Muscle Cell Proliferation Bone Development Positive Regulation Of Cartilage Development Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways		Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Signaling by Wnt deactivation of the beta-catenin transactivating complex Chromatin modifying enzymes TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer	Signaling by BMP
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ASH2L CTNNB1 ESR1 HIST2H3C MEN1 POLR2A SMAD1 SMAD9 UBC	138 interactors: ACVR1 ACVRL1 AKR1B1 ANKRD27 AP2A2 APP AR ARHGEF6 ARL4D BMPR1A BTBD2 BTG2 CAMSAP1 CDK7 CDK9 CHMP3 COL4A1 DVL1 ECSIT EIF2AK4 ELP3 EP300 ERBB2IP EWSR1 FBXL12 FBXO30 FHL5 FOXG1 FRZB GDF6 GLI3 GMEB1 GSC GSK3B HBP1 HIPK2 HOXA13 HOXA5 HOXC8 HOXD13 ICK ING2 INPP4A IRF2BP1 KAT2B KMT2D LEF1 LEMD3 MAPK1 MAST4 MBD1 MECOM MED6 MEN1 MGA MKL2 NAT9 NEDD4 NEDD9 NEUROG1 NKX3-2 NOTCH2 OAZ1 OAZ3 PAK1 PARD3B PIAS1 PIAS4 PIGQ PLEKHB1 PREB PSMB4 PSMD1 PSMD11 PUM1 RAB2B RAB30 RAB34 RAB38 RAB3B RAB6B RAC2 RAN RAP2A RASD2 RASL12 RFX1 RHEBL1 RHOG RPS27A SF3B1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMARCE1 SMURF1 SMURF2 SNIP1 SNRNP70 SOX5 SQSTM1 SS18L1 STARD13 STUB1 SUV39H1 TCF20 TGFBR1 TNNT1 TOB1 TRIP6 TTF1 TTF2 UBA52 UBC UBE2Z UBXN1 USP45 VEPH1 WDR77 XPC XPO1 YAP1 YY1 ZBTB44 ZDHHC3 ZEB2 ZNF251 ZNF423 ZNF510 ZNF512B ZNF521 ZNF76 ZNF8 ZSCAN4
Entrez ID		8085	4086
HPRD ID		03664	03356
Ensembl ID		ENSG00000167548	ENSG00000170365
Uniprot IDs		O14686 Q59FG6 Q6PIA1	Q15797
PDB IDs		3UVK 4ERQ	1KHU 2LAW 2LAX 2LAY 2LAZ 2LB0 2LB1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Nucleobase-containing Compound Metabolic Process Response To Transforming Growth Factor Beta Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Response To Growth Factor Stimulus DNA-templated Transcription, Initiation Response To Growth Factor Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Osteoblast Fate Commitment Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Ossification Response To Organic Substance Urogenital System Development Response To Organic Cyclic Compound Cellular Response To Organic Cyclic Compound Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Regulation Of Osteoblast Differentiation Cellular Response To Organic Substance Kidney Epithelium Development	Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Gene Expression Regulation Of Gene Expression RNA Metabolic Process Regulation Of Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Transforming Growth Factor Beta Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Signal Transduction Regulation Of Signaling Cellular Response To Growth Factor Stimulus Pattern Specification Process Signaling Transcription From RNA Polymerase II Promoter
Tagcloud ?		aka belong bile circadian clock closest coactivator coactivators complexes disturbed fluctuation hepatic hepatology homolog impinges livers mechanistic metabolic methyltransferase mll3 mll4 named orphan pivotal regulators retinoid rhythmic transcriptome uncovered	balance cav1 collagens cytokeratin dialytic discontinuation emt eventually fibrosis fluids fn fsp hyperactivation invading junction laminin matrices mcs mek mesothelial pd peritoneal peritoneum proteomics smad2 snail stroma thickness zo
Tagcloud (Difference) ?		aka belong bile circadian clock closest coactivator coactivators complexes disturbed fluctuation hepatic hepatology homolog impinges livers mechanistic metabolic methyltransferase mll3 mll4 named orphan pivotal regulators retinoid rhythmic transcriptome uncovered	balance cav1 collagens cytokeratin dialytic discontinuation emt eventually fibrosis fluids fn fsp hyperactivation invading junction laminin matrices mcs mek mesothelial pd peritoneal peritoneum proteomics smad2 snail stroma thickness zo
Tagcloud (Intersection) ?