CSNK1A1L and TNFRSF1A

Number of citations: 0 (PubMedID 8051045)
Data Source: BioGRID (enzymatic study)

		CSNK1A1L	TNFRSF1A
Name		casein kinase 1 alpha 1 like	TNF receptor superfamily member 1A
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Golgi Membrane Tumor Necrosis Factor Receptor Superfamily Complex Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane Cell Surface Membrane Receptor Complex Membrane Raft
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Tumor Necrosis Factor Receptor Activity Protein Binding Signaling Receptor Activity Tumor Necrosis Factor Binding
	Biological Process	Signal Transduction Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway	Aortic Valve Development Pulmonary Valve Development Negative Regulation Of Extracellular Matrix Constituent Secretion Transcription By RNA Polymerase II Prostaglandin Metabolic Process Apoptotic Process Defense Response Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Amide Metabolic Process Non-canonical NF-kappaB Signal Transduction Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Cellular Response To Mechanical Stimulus Protein Localization To Plasma Membrane Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of Establishment Of Endothelial Barrier Regulation Of Membrane Lipid Metabolic Process
Pathways		None	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR1-mediated ceramide production TNFs bind their physiological receptors Interleukin-10 signaling TNF signaling
Drugs		None	6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-One Tasonermin
Diseases		None	Tumor necrosis factor receptor-associated periodic syndrome (TRAPS); Familial periodic fever
GWAS		Adiponectin levels in pregnancy ( 28317342 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Palmitoleic acid (16:1n-7) levels ( 23362303 )	Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065 ) Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065 ) Alopecia areata ( 25608926 ) Ankylosing spondylitis ( 23749187 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Colorectal cancer ( 24836286 ) Crohn's disease ( 26192919 ) Eosinophil count ( 32888494 ) Lymphocyte count ( 32888494 27863252 ) Lymphocyte percentage of white cells ( 32888494 ) Monocyte count ( 32888494 27863252 ) Multiple sclerosis ( 27386562 24076602 31604244 21833088 19525953 ) Neutrophil percentage of white cells ( 32888494 ) Platelet count ( 32888494 27863252 ) Plateletcrit ( 27863252 32888494 ) Primary biliary cholangitis ( 21399635 28425483 26394269 ) Primary biliary cirrhosis ( 22961000 ) White blood cell count ( 32888494 )
Interacting Genes		5 interacting genes: CEACAM3 CEBPE JAM2 TNFRSF1A TNFRSF1B	67 interacting genes: ADAM17 AKT1 ATF6 BAG4 BCL10 CASP10 CASP7 CCND2 CDK6 CDKN2B CHUK CLIP3 CSNK1A1L DAPK1 DAXX EGFR ERAP1 ERN1 FANCD2 GRB2 GYS2 HRG HSP90AA1 HSPA8 IKBKB IKBKG JAK1 JAK2 LTA LTB MADD MAGEH1 MAPK1 MOAP1 MYOC NSMAF PIP4K2B PRDX3 PRKCD PSMD2 PTK2 PTPN11 PTPN6 RACK1 RASSF1 RIPK1 RIPK2 RIPK3 SGTA SRC STAMBP STAT1 STK11 SUMO1 SYK TNF TNFRSF25 TNFSF13 TRADD TRAF1 TRAF2 TRAF3 TRAP1 TRPC4AP UBE2I UBQLN1 UCHL1
Entrez ID		122011	7132
HPRD ID		13095	01861
Ensembl ID		ENSG00000180138	ENSG00000067182
Uniprot IDs		Q8N752	J9PH39 P19438
PDB IDs		Not available	1EXT 1FT4 1ICH 1NCF 1TNR 7K7A 7KP7 7KP8 7KPB 8P6Q
GO Terms Enriched among Interactors		Negative Regulation Of Extracellular Matrix Constituent Secretion Pulmonary Valve Development Tumor Necrosis Factor Receptor Superfamily Complex Positive Regulation Of Apoptotic Process Involved In Morphogenesis Aortic Valve Development Tumor Necrosis Factor Binding Semi-lunar Valve Development Positive Regulation Of Apoptotic Process Involved In Development Regulation Of Extracellular Matrix Constituent Secretion Tumor Necrosis Factor Receptor Activity Heart Valve Development Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Regulation Of Myelination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Extracellular Matrix Organization Regulation Of Cardiac Muscle Hypertrophy Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Specific Granule Membrane Regulation Of System Process Extrinsic Apoptotic Signaling Pathway Regulation Of Nervous System Process Cell Surface Negative Regulation Of Secretion By Cell Cellular Response To Lipopolysaccharide Negative Regulation Of Secretion Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Inflammatory Response Glial Cell-neuron Signaling Cellular Response To Molecule Of Bacterial Origin Plasma Membrane Hematopoietic Stem Cell Migration To Bone Marrow Protein Complex Involved In Cell Adhesion Lymphocyte Aggregation Membrane Raft Regulation Of Muscle System Process Hematopoietic Stem Cell Migration Negative Regulation Of Defense Response Negative Regulation Of Myelination Negative Regulation Of Multicellular Organismal Process Response To Lipopolysaccharide Leukocyte Aggregation Apoptotic Signaling Pathway Response To Molecule Of Bacterial Origin Response To External Biotic Stimulus Defense Response Negative Regulation Of Neuroinflammatory Response Positive Regulation Of Membrane Protein Ectodomain Proteolysis DNA-templated Transcription	Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Apoptotic Process Cytosol Programmed Cell Death Cell Death Positive Regulation Of Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Cytokine-mediated Signaling Pathway Regulation Of Immune System Process Tumor Necrosis Factor Receptor Binding Regulation Of Defense Response Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Metabolic Process Signal Transduction Response To Stress Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Cellular Response To Stress Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Protein Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Signaling Pathway Kinase Activity Positive Regulation Of Apoptotic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Phosphorylation Activation Of Immune Response Immune Response-activating Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation