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EXOSC8 and LSM1
Number of citations of the paper that reports this interaction (PMID
15231747
)
44
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
EXOSC8
LSM1
Gene Name
exosome component 8
LSM1, U6 small nuclear RNA associated
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Exosome (RNase Complex)
Nucleus
Nucleolus
Cytoplasm
Cytosol
Cytoplasmic MRNA Processing Body
Nucleus
Cytoplasm
Cytosol
Molecular Function
Exoribonuclease Activity
Protein Binding
AU-rich Element Binding
RNA Cap Binding
Protein Binding
Poly(A) RNA Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RRNA Processing
Biological_process
Gene Expression
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
RNA Splicing, Via Transesterification Reactions
MRNA Processing
RNA Splicing
Gene Expression
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Histone MRNA Catabolic Process
Pathways
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
mRNA decay by 5' to 3' exoribonuclease
Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS
Schizophrenia (
22037555
)
Protein-Protein Interactions
42 interactors:
AEN
ATF2
COL23A1
COX5A
CRMP1
CWC22
DIS3
DUSP23
EXOSC1
EXOSC10
EXOSC2
EXOSC3
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC9
FAM90A1
FHOD1
FOXN3
FRG1
LSM1
LSM7
MKRN1
MORN4
MPP6
OTUD4
RASSF1
REL
RPP14
SKIV2L2
SNRPC
TCEA2
TFAP4
TXNDC17
TXNDC9
UBC
UPF2
USP6
XRN1
XRN2
ZFP36
25 interactors:
CLIC1
EXOSC6
EXOSC8
GLUD1
GRHPR
HSP90AA1
LSM2
LSM3
LSM4
LSM5
LSM6
LSM7
MPDU1
N4BP1
NARS
NDUFAF3
PSMB5
PSMB8
PTPRC
RRP1B
SMN1
TMEM214
UPF2
UXT
VPS11
Entrez ID
11340
27257
HPRD ID
09351
06281
Ensembl ID
ENSG00000120699
ENSG00000175324
Uniprot IDs
Q96B26
O15116
PDB IDs
2NN6
Enriched GO Terms of Interacting Partners
?
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
MRNA Metabolic Process
RRNA Metabolic Process
RRNA Processing
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Ribosome Biogenesis
Aromatic Compound Catabolic Process
Nuclear MRNA Surveillance
Ribonucleoprotein Complex Biogenesis
RNA Metabolic Process
Cellular Macromolecule Catabolic Process
NcRNA Metabolic Process
RNA Surveillance
RNA Phosphodiester Bond Hydrolysis
RRNA Catabolic Process
Nucleobase-containing Compound Metabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Maturation Of 5.8S RRNA
Gene Expression
Cellular Nitrogen Compound Metabolic Process
Catabolic Process
Nitrogen Compound Metabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
DNA Deamination
Histone MRNA Catabolic Process
RNA Processing
Cellular Metabolic Process
Histone MRNA Metabolic Process
MRNA Processing
Intracellular MRNA Localization
Metabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Polyadenylation-dependent SnoRNA 3'-end Processing
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
U4 SnRNA 3'-end Processing
TRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
DNA Modification
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RNA Splicing
SnoRNA Metabolic Process
RNA Splicing, Via Transesterification Reactions
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
RNA Catabolic Process
MRNA Metabolic Process
Cellular Macromolecule Catabolic Process
Aromatic Compound Catabolic Process
RNA Splicing
Catabolic Process
MRNA Processing
Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
RNA Processing
Gene Expression
RNA Metabolic Process
NcRNA Metabolic Process
RRNA Processing
RRNA Metabolic Process
Ribonucleoprotein Complex Biogenesis
Ribosome Biogenesis
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Cellular Metabolic Process
Cell Cycle Phase Transition
Negative Regulation Of Protein Ubiquitination
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Protein Ubiquitination
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Signal Transduction Involved In DNA Damage Checkpoint
Signal Transduction Involved In Cell Cycle Checkpoint
Immunoglobulin Production
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Immunoglobulin Biosynthetic Process
Positive Regulation Of Hematopoietic Stem Cell Migration
Mitotic Cell Cycle Phase Transition
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Mitotic G1 DNA Damage Checkpoint
Positive Regulation Of Ubiquitin-protein Transferase Activity
Mitotic G1/S Transition Checkpoint
G1 DNA Damage Checkpoint
Positive Regulation Of Cell Cycle Arrest
Positive Regulation Of Ligase Activity
Tagcloud
?
activators
cerevisiae
codons
dcp1
dcp2
deadenylation
decapping
decay
defines
dhh1
edc1
edc2
edc3
hybrid
nmd
nonsense
overlapping
pat1
premature
proper
recruit
saccharomyces
stimulators
termed
termination
transcripts
upf1
upf2
upf3
Tagcloud (Difference)
?
activators
cerevisiae
codons
dcp1
dcp2
deadenylation
decapping
decay
defines
dhh1
edc1
edc2
edc3
hybrid
nmd
nonsense
overlapping
pat1
premature
proper
recruit
saccharomyces
stimulators
termed
termination
transcripts
upf1
upf2
upf3
Tagcloud (Intersection)
?