EXOSC8 and TXNDC9

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		EXOSC8	TXNDC9
Gene Name		exosome component 8	thioredoxin domain containing 9
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol	Cellular_component Nucleus Cytoplasm Centrosome Midbody
	Molecular Function	Exoribonuclease Activity Protein Binding AU-rich Element Binding	Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Biological_process Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	Biological_process Cell Redox Homeostasis
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		42 interactors: AEN ATF2 COL23A1 COX5A CRMP1 CWC22 DIS3 DUSP23 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM90A1 FHOD1 FOXN3 FRG1 LSM1 LSM7 MKRN1 MORN4 MPP6 OTUD4 RASSF1 REL RPP14 SKIV2L2 SNRPC TCEA2 TFAP4 TXNDC17 TXNDC9 UBC UPF2 USP6 XRN1 XRN2 ZFP36	19 interactors: C1orf94 C3orf62 CCDC172 CEP76 CHD3 DYDC1 EXOSC8 FEZ1 GIT1 IKBKAP IMMT KIAA1377 KLF11 MAGEA6 MYOG PNMA1 PTN SETDB1 TRIM27
Entrez ID		11340	10190
HPRD ID		09351	15592
Ensembl ID		ENSG00000120699	ENSG00000115514
Uniprot IDs		Q96B26	O14530
PDB IDs		2NN6
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process RRNA Metabolic Process RRNA Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Ribosome Biogenesis Aromatic Compound Catabolic Process Nuclear MRNA Surveillance Ribonucleoprotein Complex Biogenesis RNA Metabolic Process Cellular Macromolecule Catabolic Process NcRNA Metabolic Process RNA Surveillance RNA Phosphodiester Bond Hydrolysis RRNA Catabolic Process Nucleobase-containing Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Maturation Of 5.8S RRNA Gene Expression Cellular Nitrogen Compound Metabolic Process Catabolic Process Nitrogen Compound Metabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process DNA Deamination Histone MRNA Catabolic Process RNA Processing Cellular Metabolic Process Histone MRNA Metabolic Process MRNA Processing Intracellular MRNA Localization Metabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' DNA Modification Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA Splicing SnoRNA Metabolic Process RNA Splicing, Via Transesterification Reactions	Cell Cycle Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Muscle Atrophy Negative Regulation Of Interleukin-2 Secretion Response To Muscle Activity Involved In Regulation Of Muscle Adaptation
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