EXOSC8 and RPLP0

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		EXOSC8	RPLP0
Description		exosome component 8	ribosomal protein lateral stalk subunit P0
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Postsynapse Ribonucleoprotein Complex
	Molecular Function	RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Large Ribosomal Subunit RRNA Binding
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway	Cytoplasmic Translation Translation Ribosome Biogenesis
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS			Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		112 interacting genes: AEN ANKHD1 ATF2 C22orf39 CCDC28A-AS1 CCL14 CCSER2 CNNM3 COL23A1 COX5A CPSF7 CRMP1 CWC22 DDIT4L DIS3 DUSP23 ERAL1 EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM161B FAM90A1 FHOD1 FOXD4L1 FOXN3 FRG1 FSAF1 FYTTD1 GEM HAPLN2 HOXB9 ILF2 INCA1 KANK2 KCNJ11 LENG1 LMO4 LNX1 LSM1 LSM4 LSM7 MACIR METTL14 MKRN1 MORN4 MRPL2 MTREX MYOZ1 NEDD9 NTAQ1 NXF1 OTUD4 PACSIN2 PALS2 PHF21A PIAS2 PKP2 POLDIP3 PRC1 PRPF31 PRPF6 PRR3 RASD1 RASSF1 RBBP4 RBM22 RBM7 REL RFC5 RPL3 RPLP0 RPP14 RPS28 RUSC1 RXRB SARNP SF1 SFPQ SGO2 SLAIN1 SLIRP SNAI1 SNRPA SNRPB SNRPC SNRPN SNW1 SOCS7 SPATC1L SRPK2 SRSF10 SUGP2 TBRG1 TCEA2 TFAP4 TFIP11 TXNDC17 TXNDC9 UBC UNKL UPF2 USP2 USP6 UTP14A XRN1 XRN2 ZFP36	15 interacting genes: CSNK2A1 ERG EXOSC8 GAS7 KRI1 LINC00632 OGT PAFAH1B2 PPM1A PRPF40A PTEN SMAD3 STAU1 USP7 YWHAQ
Entrez ID		11340	6175
HPRD ID		09351	01610
Ensembl ID		ENSG00000120699	ENSG00000089157
Uniprot IDs		Q96B26	P05388
PDB IDs		2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P	4V6W 4V6X 5AJ0 6OLG 6ZM7 6ZME 6ZMI 6ZMO 8G5Z 8G60 8G6J 8K2C 8UKB 8XSX 8XSY 8XSZ 8YOO 8YOP
Enriched GO Terms of Interacting Partners?		RNA Binding MRNA Metabolic Process Exosome (RNase Complex) RNA Processing RNA Metabolic Process Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleic Acid Metabolic Process Nucleolar Exosome (RNase Complex) RNA Splicing, Via Transesterification Reactions Nucleus Nuclear-transcribed MRNA Catabolic Process Nuclear MRNA Surveillance RNA Catabolic Process MRNA Splicing, Via Spliceosome MRNA Catabolic Process RNA Exonuclease Activity MRNA Processing RNA Splicing Nucleoplasm Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Nuclear RNA Surveillance U4 SnRNA 3'-end Processing RNA Surveillance RRNA Catabolic Process 3'-5'-RNA Exonuclease Activity Nucleobase-containing Compound Catabolic Process Nucleic Acid Binding SnRNA Metabolic Process RRNA Metabolic Process RRNA Processing Catalytic Step 2 Spliceosome Poly(A)-dependent SnoRNA 3'-end Processing SnRNA 3'-end Processing Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex Macromolecule Metabolic Process Nucleolus Exoribonuclease Complex Negative Regulation Of Macromolecule Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Metabolic Process SnRNA Processing RNA 3'-end Processing Negative Regulation Of Macromolecule Biosynthetic Process Protein Binding	Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Stabilization Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Rhythmic Process Negative Regulation Of Macromolecule Metabolic Process PML Body Negative Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Sin3-type Complex Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Protein Stability Negative Regulation Of Biosynthetic Process Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Gene Expression R-SMAD Binding Negative Regulation Of Catabolic Process Regulation Of Proteolysis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Identical Protein Binding Positive Regulation Of Autophagy Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Translational Initiation Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Negative Regulation Of Synaptic Vesicle Clustering Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Cellular Localization Regulation Of Gluconeogenesis Cytosol Positive Regulation Of Catabolic Process Membraneless Organelle Assembly Regulation Of Gene Expression Negative Regulation Of Osteoblast Differentiation Regulation Of Cell Junction Assembly Positive Regulation Of Transforming Growth Factor Beta3 Production Regulation Of Focal Adhesion Assembly Negative Regulation Of Wound Healing Positive Regulation Of Nucleocytoplasmic Transport Cellular Response To Glucose Stimulus Regulation Of Intracellular Transport Response To Transforming Growth Factor Beta
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