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EXOSC8 and RASSF1
Number of citations of the paper that reports this interaction (PMID
15231747
)
44
Data Source:
HPRD
(two hybrid)
EXOSC8
RASSF1
Gene Name
exosome component 8
Ras association (RalGDS/AF-6) domain family member 1
Image
Gene Ontology Annotations
Cellular Component
Exosome (RNase Complex)
Nucleus
Nucleolus
Cytoplasm
Cytosol
Spindle Pole
Nucleus
Cytoplasm
Microtubule Organizing Center
Microtubule
Plasma Membrane
Microtubule Cytoskeleton
Molecular Function
Exoribonuclease Activity
Protein Binding
AU-rich Element Binding
Protein Binding
Zinc Ion Binding
Identical Protein Binding
Protein N-terminus Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RRNA Processing
Biological_process
Gene Expression
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Cellular Response To DNA Damage Stimulus
Cell Cycle Arrest
Ras Protein Signal Transduction
Positive Regulation Of Protein Ubiquitination
Protein Stabilization
Negative Regulation Of Cell Cycle Arrest
Pathways
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions
42 interactors:
AEN
ATF2
COL23A1
COX5A
CRMP1
CWC22
DIS3
DUSP23
EXOSC1
EXOSC10
EXOSC2
EXOSC3
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC9
FAM90A1
FHOD1
FOXN3
FRG1
LSM1
LSM7
MKRN1
MORN4
MPP6
OTUD4
RASSF1
REL
RPP14
SKIV2L2
SNRPC
TCEA2
TFAP4
TXNDC17
TXNDC9
UBC
UPF2
USP6
XRN1
XRN2
ZFP36
33 interactors:
ATP2B4
AURKA
AURKB
C7orf25
C8orf33
CDC20
CNKSR1
DAXX
DDB1
E4F1
EXOSC8
HRAS
IGFBP5
KCNE3
KDM1A
MAP1B
MAP1S
MAPK8
MDM2
MOAP1
MST1
NUDT10
RASSF5
SAV1
STK3
STK4
SUV39H1
SUV39H2
TNFRSF10A
TNFRSF1A
TUBB
TUBG1
XPA
Entrez ID
11340
11186
HPRD ID
09351
05470
Ensembl ID
ENSG00000120699
ENSG00000068028
Uniprot IDs
Q96B26
Q9NS23
PDB IDs
2NN6
2KZU
Enriched GO Terms of Interacting Partners
?
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
MRNA Metabolic Process
RRNA Metabolic Process
RRNA Processing
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Ribosome Biogenesis
Aromatic Compound Catabolic Process
Nuclear MRNA Surveillance
Ribonucleoprotein Complex Biogenesis
RNA Metabolic Process
Cellular Macromolecule Catabolic Process
NcRNA Metabolic Process
RNA Surveillance
RNA Phosphodiester Bond Hydrolysis
RRNA Catabolic Process
Nucleobase-containing Compound Metabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Maturation Of 5.8S RRNA
Gene Expression
Cellular Nitrogen Compound Metabolic Process
Catabolic Process
Nitrogen Compound Metabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
DNA Deamination
Histone MRNA Catabolic Process
RNA Processing
Cellular Metabolic Process
Histone MRNA Metabolic Process
MRNA Processing
Intracellular MRNA Localization
Metabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Polyadenylation-dependent SnoRNA 3'-end Processing
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
U4 SnRNA 3'-end Processing
TRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
DNA Modification
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RNA Splicing
SnoRNA Metabolic Process
RNA Splicing, Via Transesterification Reactions
Regulation Of Apoptotic Process
Apoptotic Process
Programmed Cell Death
Regulation Of Cell Death
Cell Death
Death
Regulation Of Protein Binding
Intracellular Signal Transduction
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Apoptotic Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Binding
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Cell Death
Hippo Signaling
Response To Abiotic Stimulus
Mitotic Cell Cycle Process
Positive Regulation Of Protein Modification Process
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Organ Growth
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Primitive Hemopoiesis
Mitotic Cell Cycle
Peptidyl-serine Phosphorylation
Positive Regulation Of Transferase Activity
Cell Cycle
Response To UV
Negative Regulation Of Protein Binding
Signal Transduction By Phosphorylation
Cellular Response To Stress
Regulation Of Signaling
Positive Regulation Of Protein Kinase Activity
Organelle Organization
Endocardium Development
Positive Regulation Of Kinase Activity
Positive Regulation Of Signal Transduction
Hepatocyte Apoptotic Process
Positive Regulation Of Protein Phosphorylation
Regulation Of Signal Transduction
Negative Regulation Of Gene Expression
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Cell Cycle Process
Response To Light Stimulus
Negative Regulation Of Developmental Growth
Positive Regulation Of Cellular Metabolic Process
Tagcloud
?
bat
braf
cimp
clinicopathological
comparatively
dapk
develops
discrete
g15s
gstp1
hierarchical
hmlh1
inc
india
indian
kras
mint1
mint2
mint31
mononucleotide
msi
mss
periodicals
poorest
rectal
tp53
unfavorable
v600e
wiley
Tagcloud (Difference)
?
bat
braf
cimp
clinicopathological
comparatively
dapk
develops
discrete
g15s
gstp1
hierarchical
hmlh1
inc
india
indian
kras
mint1
mint2
mint31
mononucleotide
msi
mss
periodicals
poorest
rectal
tp53
unfavorable
v600e
wiley
Tagcloud (Intersection)
?