EXOSC8 and ATF2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		EXOSC8	ATF2
Description		exosome component 8	activating transcription factor 2
Image
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Site Of Double-strand Break RNA Polymerase II Transcription Regulator Complex H4 Histone Acetyltransferase Complex
	Molecular Function	RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding CAMP Response Element Binding Protein Binding Zinc Ion Binding Histone H4 Acetyltransferase Activity Protein Kinase Binding CAMP Response Element Binding Identical Protein Binding Protein Homodimerization Activity Leucine Zipper Domain Binding Sequence-specific DNA Binding Histone H2B Acetyltransferase Activity Metal Ion Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade In Utero Embryonic Development NK T Cell Differentiation Liver Development Hematopoietic Progenitor Cell Differentiation Outflow Tract Morphogenesis Brainstem Development Growth Plate Cartilage Chondrocyte Differentiation Growth Plate Cartilage Chondrocyte Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Lipid Metabolic Process Apoptotic Process Response To Osmotic Stress DNA Damage Response Vacuole Organization JNK Cascade Heart Development Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Angiogenesis Peptidyl-threonine Phosphorylation Abducens Nucleus Development Hypoglossal Nucleus Development Facial Nucleus Development BMP Signaling Pathway Mitotic Intra-S DNA Damage Checkpoint Signaling Positive Regulation Of Transforming Growth Factor Beta2 Production Cellular Response To Oxidative Stress P38MAPK Cascade MRNA Transcription By RNA Polymerase II Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II White Fat Cell Differentiation Positive Regulation Of DNA-binding Transcription Factor Activity Neurofilament Cytoskeleton Organization Detection Of Cell Density Adipose Tissue Development Cellular Response To Anisomycin Motor Neuron Apoptotic Process Hepatocyte Apoptotic Process Cellular Response To Virus Positive Regulation Of Cardiac Muscle Myoblast Proliferation Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Apoptotic Process Involved In Development Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Cellular Response To Leucine Starvation
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	Transcriptional activation of mitochondrial biogenesis HATs acetylate histones Activation of the AP-1 family of transcription factors TP53 Regulates Transcription of DNA Repair Genes Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2
Drugs			Pseudoephedrine
Diseases
GWAS			Intake of total sugars ( 31005972) Metabolite levels ( 23823483)
Interacting Genes		112 interacting genes: AEN ANKHD1 ATF2 C22orf39 CCDC28A-AS1 CCL14 CCSER2 CNNM3 COL23A1 COX5A CPSF7 CRMP1 CWC22 DDIT4L DIS3 DUSP23 ERAL1 EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM161B FAM90A1 FHOD1 FOXD4L1 FOXN3 FRG1 FSAF1 FYTTD1 GEM HAPLN2 HOXB9 ILF2 INCA1 KANK2 KCNJ11 LENG1 LMO4 LNX1 LSM1 LSM4 LSM7 MACIR METTL14 MKRN1 MORN4 MRPL2 MTREX MYOZ1 NEDD9 NTAQ1 NXF1 OTUD4 PACSIN2 PALS2 PHF21A PIAS2 PKP2 POLDIP3 PRC1 PRPF31 PRPF6 PRR3 RASD1 RASSF1 RBBP4 RBM22 RBM7 REL RFC5 RPL3 RPLP0 RPP14 RPS28 RUSC1 RXRB SARNP SF1 SFPQ SGO2 SLAIN1 SLIRP SNAI1 SNRPA SNRPB SNRPC SNRPN SNW1 SOCS7 SPATC1L SRPK2 SRSF10 SUGP2 TBRG1 TCEA2 TFAP4 TFIP11 TXNDC17 TXNDC9 UBC UNKL UPF2 USP2 USP6 UTP14A XRN1 XRN2 ZFP36	61 interacting genes: APP AR ATF3 ATF4 ATF7 BACH1 BANP BATF CCDC6 CCND1 CEBPA CEBPB CEBPG CREB5 CSNK2A1 CSNK2A2 DDIT3 DNMT3L EDF1 ETS1 EXOSC8 FAM13A-AS1 FOS GTF2F2 H2BC21 HMGA1 IRF2BP1 JDP2 JUN KIFC3 LHX8 MACROH2A1 MAPK1 MAPK10 MAPK11 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK5 MLH1 NBN NCOA6 PIAS2 PML PRKCE RB1 RNF4 RPS6KA5 RUVBL2 SMAD3 SMAD4 SPOPL SRA1 SUMO1 THRB UBE2I USP14 UTF1 XPO1 YY1
Entrez ID		11340	1386
HPRD ID		09351	00443
Ensembl ID		ENSG00000120699	ENSG00000115966
Uniprot IDs		Q96B26	A4D7V5 P15336
PDB IDs		2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P	1BHI 1T2K 4H36 6ZQS 6ZR5
Enriched GO Terms of Interacting Partners?		RNA Binding MRNA Metabolic Process Exosome (RNase Complex) RNA Processing RNA Metabolic Process Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleic Acid Metabolic Process Nucleolar Exosome (RNase Complex) RNA Splicing, Via Transesterification Reactions Nucleus Nuclear-transcribed MRNA Catabolic Process Nuclear MRNA Surveillance RNA Catabolic Process MRNA Splicing, Via Spliceosome MRNA Catabolic Process RNA Exonuclease Activity MRNA Processing RNA Splicing Nucleoplasm Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Nuclear RNA Surveillance U4 SnRNA 3'-end Processing RNA Surveillance RRNA Catabolic Process 3'-5'-RNA Exonuclease Activity Nucleobase-containing Compound Catabolic Process Nucleic Acid Binding SnRNA Metabolic Process RRNA Metabolic Process RRNA Processing Catalytic Step 2 Spliceosome Poly(A)-dependent SnoRNA 3'-end Processing SnRNA 3'-end Processing Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex Macromolecule Metabolic Process Nucleolus Exoribonuclease Complex Negative Regulation Of Macromolecule Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Metabolic Process SnRNA Processing RNA 3'-end Processing Negative Regulation Of Macromolecule Biosynthetic Process Protein Binding	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Intracellular Signaling Cassette Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Enzyme Binding Chromatin Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process MAP Kinase Activity DNA Binding Response To Stress Transcription Cis-regulatory Region Binding Integrated Stress Response Signaling Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity MAPK Cascade RNA Polymerase II-specific DNA-binding Transcription Factor Binding Macromolecule Metabolic Process DNA Damage Response DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cellular Senescence Chromatin Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
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