EGLN2 and A2M

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		EGLN2	A2M
Gene Name		egl-9 family hypoxia-inducible factor 2	alpha-2-macroglobulin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Extracellular Region Cytosol Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein Binding Ferrous Iron Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Oxygen Sensor Activity L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity	Protease Binding Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding
	Biological Process	Regulation Of Cell Growth Response To Hypoxia Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Intracellular Estrogen Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Cell Redox Homeostasis Positive Regulation Of Protein Catabolic Process Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Small GTPase Mediated Signal Transduction Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Lipoprotein metabolism Metabolism of lipids and lipoproteins Platelet degranulation Lipid digestion, mobilization, and transport Degradation of the extracellular matrix Formation of Fibrin Clot (Clotting Cascade) Rho GTPase cycle Intrinsic Pathway HDL-mediated lipid transport Response to elevated platelet cytosolic Ca2+ Signaling by Rho GTPases Platelet activation, signaling and aggregation
Drugs			Becaplermin Bacitracin Ocriplasmin
Diseases
GWAS		Chronic obstructive pulmonary disease ( 22080838) Smoking behavior ( 20418890)
Protein-Protein Interactions		7 interactors: A2M EPAS1 FAM46A HIF1A HIF3A MOB4 SRPK2	93 interactors: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AFX HMOX2 HSPA5 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK13 KLK2 KLK3 LCAT LEP LONP1 LRP1 LYZ MAST1 MGEA5 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPT8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1L UMPS
Entrez ID		112398	2
HPRD ID		06970	00072
Ensembl ID		ENSG00000269858	ENSG00000175899
Uniprot IDs		Q96KS0	P01023
PDB IDs			1BV8 2P9R 4ACQ
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Response To Hypoxia Stem Cell Differentiation Angiogenesis Blood Vessel Morphogenesis Nuclear Speck Organization Neural Fold Elevation Formation Blood Vessel Development Vasculature Development Tissue Remodeling Embryonic Placenta Development Iron Ion Homeostasis Elastin Metabolic Process Negative Regulation Of Complement Activation, Lectin Pathway Cell Maturation Transition Metal Ion Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Vascular Endothelial Growth Factor Production Response To Stress Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Intestinal Epithelial Cell Maturation Placenta Development Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Oxidative Stress Cardiovascular System Development Transcription From RNA Polymerase II Promoter Hemoglobin Biosynthetic Process Axon Transport Of Mitochondrion Wound Healing Involved In Inflammatory Response Oxygen Homeostasis Negative Regulation Of Thymocyte Apoptotic Process Myoblast Fate Commitment Regulation Of Neuron Apoptotic Process Homeostasis Of Number Of Cells B-1 B Cell Homeostasis Stem Cell Development Negative Regulation Of Oxidative Stress-induced Neuron Death Anatomical Structure Formation Involved In Morphogenesis Regulation Of Transforming Growth Factor Beta2 Production Response To Abiotic Stimulus Positive Regulation Of Receptor Biosynthetic Process Lactate Metabolic Process	Response To Abiotic Stimulus Response To Stress Regulation Of Cell Activation Response To Stimulus Response To External Stimulus Developmental Process Anatomical Structure Development Regulation Of Immune Response Response To Organic Substance Cellular Response To Stimulus Response To Drug System Development Multicellular Organismal Development Hemostasis Defense Response Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Regulation Of Immune System Process Blood Coagulation Negative Regulation Of Blood Coagulation Regulation Of Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Organ Development Cellular Response To Organic Substance Negative Regulation Of Wound Healing Regulation Of Protein Metabolic Process Response To Hormone Catabolic Process Negative Regulation Of Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Platelet Activation Phosphatidylinositol-mediated Signaling Immune Response Regulation Of Phosphorylation Regulation Of Signaling Reproductive Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of DNA Metabolic Process Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Wounding Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Wound Healing
Tagcloud ?		altering avenue cyclin d1 deubiquitinase egln1 egln3 foxo foxo3a hif hydroxylases hydroxylate hydroxylation insights leads pharmacologically prevents prolyl promotes promoting proteasomal regulate repress stability suppresses thereby turn usp9x	a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither
Tagcloud (Difference) ?		altering avenue cyclin d1 deubiquitinase egln1 egln3 foxo foxo3a hif hydroxylases hydroxylate hydroxylation insights leads pharmacologically prevents prolyl promotes promoting proteasomal regulate repress stability suppresses thereby turn usp9x	a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither
Tagcloud (Intersection) ?