EGLN2 and FAM46A

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EGLN2	FAM46A
Gene Name		egl-9 family hypoxia-inducible factor 2	family with sequence similarity 46, member A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding Ferrous Iron Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Oxygen Sensor Activity L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity	Poly(A) RNA Binding
	Biological Process	Regulation Of Cell Growth Response To Hypoxia Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Intracellular Estrogen Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Cell Redox Homeostasis Positive Regulation Of Protein Catabolic Process Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia	Regulation Of Gene Expression Regulation Of Blood Coagulation
Pathways		Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 22080838) Smoking behavior ( 20418890)	Breast cancer ( 22976474) Corneal structure ( 23291589) Height ( 20881960 23563607)
Protein-Protein Interactions		7 interactors: A2M EPAS1 FAM46A HIF1A HIF3A MOB4 SRPK2	16 interactors: ATXN1 BAG6 BCCIP CD93 COL4A2 DYNC1H1 EGLN2 HDLBP HTRA1 KEAP1 NR2F2 PSG3 RNF14 SPINT1 TBX4 ZFYVE9
Entrez ID		112398	55603
HPRD ID		06970	13311
Ensembl ID		ENSG00000269858	ENSG00000112773
Uniprot IDs		Q96KS0	Q96IP4
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Response To Hypoxia Stem Cell Differentiation Angiogenesis Blood Vessel Morphogenesis Nuclear Speck Organization Neural Fold Elevation Formation Blood Vessel Development Vasculature Development Tissue Remodeling Embryonic Placenta Development Iron Ion Homeostasis Elastin Metabolic Process Negative Regulation Of Complement Activation, Lectin Pathway Cell Maturation Transition Metal Ion Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Vascular Endothelial Growth Factor Production Response To Stress Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Intestinal Epithelial Cell Maturation Placenta Development Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Oxidative Stress Cardiovascular System Development Transcription From RNA Polymerase II Promoter Hemoglobin Biosynthetic Process Axon Transport Of Mitochondrion Wound Healing Involved In Inflammatory Response Oxygen Homeostasis Negative Regulation Of Thymocyte Apoptotic Process Myoblast Fate Commitment Regulation Of Neuron Apoptotic Process Homeostasis Of Number Of Cells B-1 B Cell Homeostasis Stem Cell Development Negative Regulation Of Oxidative Stress-induced Neuron Death Anatomical Structure Formation Involved In Morphogenesis Regulation Of Transforming Growth Factor Beta2 Production Response To Abiotic Stimulus Positive Regulation Of Receptor Biosynthetic Process Lactate Metabolic Process	Embryo Development Placenta Blood Vessel Development Intracellular Receptor Signaling Pathway Blood Vessel Development Vasculature Development Lung Development Respiratory Tube Development Radial Pattern Formation Respiratory System Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Transcription Involved In Lymphatic Endothelial Cell Fate Commitment Anatomical Structure Development Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cardiovascular System Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cellular Response To Growth Factor Stimulus Transcription, DNA-templated Blood Vessel Morphogenesis Dentinogenesis Proteasomal Ubiquitin-independent Protein Catabolic Process Embryonic Placenta Development Response To Estradiol RNA Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Process Tissue Development In Utero Embryonic Development Neuroendocrine Cell Differentiation Tail-anchored Membrane Protein Insertion Into ER Membrane Epithelium Development
Tagcloud ?		altering avenue cyclin d1 deubiquitinase egln1 egln3 foxo foxo3a hif hydroxylases hydroxylate hydroxylation insights leads pharmacologically prevents prolyl promotes promoting proteasomal regulate repress stability suppresses thereby turn usp9x	al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel ppp2r4 reannotation reserve scc sprr2d stxbp5 tongue tumorigenic validate
Tagcloud (Difference) ?		altering avenue cyclin d1 deubiquitinase egln1 egln3 foxo foxo3a hif hydroxylases hydroxylate hydroxylation insights leads pharmacologically prevents prolyl promotes promoting proteasomal regulate repress stability suppresses thereby turn usp9x	al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel ppp2r4 reannotation reserve scc sprr2d stxbp5 tongue tumorigenic validate
Tagcloud (Intersection) ?