EGLN2 and MOB4

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		EGLN2	MOB4
Gene Name		egl-9 family hypoxia-inducible factor 2	MOB family member 4, phocein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Cytoplasm Golgi Apparatus Cytosol Golgi Cisterna Membrane Neuronal Cell Body Dendritic Spine Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Ferrous Iron Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Oxygen Sensor Activity L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity	Protein Binding Kinase Binding Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Response To Hypoxia Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Intracellular Estrogen Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Cell Redox Homeostasis Positive Regulation Of Protein Catabolic Process Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia	Transport
Pathways		Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 22080838) Smoking behavior ( 20418890)
Protein-Protein Interactions		7 interactors: A2M EPAS1 FAM46A HIF1A HIF3A MOB4 SRPK2	31 interactors: ARHGEF15 CCDC85B CRMP1 DNM1 EGFR EGLN2 ELK1 EPS15 FADD FBLN1 GDF9 KIDINS220 LATS1 LATS2 LRIF1 MCM2 MED10 MED31 MYL6 MYO9B NME2 PAICS PLEKHM1 PTPRS RAPGEF2 SCMH1 SETDB1 STK11 STK3 THAP4 UBE2V2
Entrez ID		112398	25843
HPRD ID		06970	10165
Ensembl ID		ENSG00000269858	ENSG00000115540
Uniprot IDs		Q96KS0	B4DM50 Q9Y3A3
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Response To Hypoxia Stem Cell Differentiation Angiogenesis Blood Vessel Morphogenesis Nuclear Speck Organization Neural Fold Elevation Formation Blood Vessel Development Vasculature Development Tissue Remodeling Embryonic Placenta Development Iron Ion Homeostasis Elastin Metabolic Process Negative Regulation Of Complement Activation, Lectin Pathway Cell Maturation Transition Metal Ion Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Vascular Endothelial Growth Factor Production Response To Stress Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Intestinal Epithelial Cell Maturation Placenta Development Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Oxidative Stress Cardiovascular System Development Transcription From RNA Polymerase II Promoter Hemoglobin Biosynthetic Process Axon Transport Of Mitochondrion Wound Healing Involved In Inflammatory Response Oxygen Homeostasis Negative Regulation Of Thymocyte Apoptotic Process Myoblast Fate Commitment Regulation Of Neuron Apoptotic Process Homeostasis Of Number Of Cells B-1 B Cell Homeostasis Stem Cell Development Negative Regulation Of Oxidative Stress-induced Neuron Death Anatomical Structure Formation Involved In Morphogenesis Regulation Of Transforming Growth Factor Beta2 Production Response To Abiotic Stimulus Positive Regulation Of Receptor Biosynthetic Process Lactate Metabolic Process	Developmental Process Anatomical Structure Development Cell Differentiation Positive Regulation Of Protein Metabolic Process Multicellular Organismal Development Regulation Of Metabolic Process Regulation Of Cellular Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Metabolic Process Hippo Signaling Regulation Of Protein Metabolic Process Regulation Of Neuron Projection Development Signal Transduction Positive Regulation Of Neuron Projection Development System Development Cellular Response To Stimulus Regulation Of Cellular Component Organization Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Signaling Neurogenesis Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell Projection Organization Regulation Of Cell Projection Organization Cell Communication Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Neuron Projection Development Regulation Of Phosphorus Metabolic Process Cellular Response To Organic Substance Nervous System Development Cell Projection Organization Regulation Of Signal Transduction Cell Projection Morphogenesis Response To Stimulus Positive Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Cell Part Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Death
Tagcloud ?		altering avenue cyclin d1 deubiquitinase egln1 egln3 foxo foxo3a hif hydroxylases hydroxylate hydroxylation insights leads pharmacologically prevents prolyl promotes promoting proteasomal regulate repress stability suppresses thereby turn usp9x
Tagcloud (Difference) ?		altering avenue cyclin d1 deubiquitinase egln1 egln3 foxo foxo3a hif hydroxylases hydroxylate hydroxylation insights leads pharmacologically prevents prolyl promotes promoting proteasomal regulate repress stability suppresses thereby turn usp9x
Tagcloud (Intersection) ?