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EGLN2
Gene Name
egl-9 family hypoxia-inducible factor 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Molecular Function
Protein Binding
Ferrous Iron Binding
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors
Oxygen Sensor Activity
L-ascorbic Acid Binding
Peptidyl-proline 4-dioxygenase Activity
Biological Process
Regulation Of Cell Growth
Response To Hypoxia
Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline
Intracellular Estrogen Receptor Signaling Pathway
Regulation Of Neuron Apoptotic Process
Cell Redox Homeostasis
Positive Regulation Of Protein Catabolic Process
Oxidation-reduction Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hypoxia
Pathways
Cellular response to hypoxia
Regulation of Hypoxia-inducible Factor (HIF) by oxygen
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs
Diseases
GWAS
Chronic obstructive pulmonary disease (
22080838
)
Smoking behavior (
20418890
)
Protein-protein Interactions
7 interactors:
A2M
EPAS1
FAM46A
HIF1A
HIF3A
MOB4
SRPK2
Entrez ID
112398
HPRD ID
06970
Ensembl ID
ENSG00000269858
Uniprot IDs
Q96KS0
PDB IDs
Enriched GO Terms of Interacting Partners
?
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Cellular Response To Oxygen Levels
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Response To Hypoxia
Stem Cell Differentiation
Angiogenesis
Blood Vessel Morphogenesis
Nuclear Speck Organization
Neural Fold Elevation Formation
Blood Vessel Development
Vasculature Development
Tissue Remodeling
Embryonic Placenta Development
Iron Ion Homeostasis
Elastin Metabolic Process
Negative Regulation Of Complement Activation, Lectin Pathway
Cell Maturation
Transition Metal Ion Homeostasis
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Positive Regulation Of Chemokine-mediated Signaling Pathway
Vascular Endothelial Growth Factor Production
Response To Stress
Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development
Intestinal Epithelial Cell Maturation
Placenta Development
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Cellular Response To Oxidative Stress
Cardiovascular System Development
Transcription From RNA Polymerase II Promoter
Hemoglobin Biosynthetic Process
Axon Transport Of Mitochondrion
Wound Healing Involved In Inflammatory Response
Oxygen Homeostasis
Negative Regulation Of Thymocyte Apoptotic Process
Myoblast Fate Commitment
Regulation Of Neuron Apoptotic Process
Homeostasis Of Number Of Cells
B-1 B Cell Homeostasis
Stem Cell Development
Negative Regulation Of Oxidative Stress-induced Neuron Death
Anatomical Structure Formation Involved In Morphogenesis
Regulation Of Transforming Growth Factor Beta2 Production
Response To Abiotic Stimulus
Positive Regulation Of Receptor Biosynthetic Process
Lactate Metabolic Process
Tagcloud
?
altering
avenue
cyclin
d1
deubiquitinase
egln1
egln3
foxo
foxo3a
hif
hydroxylases
hydroxylate
hydroxylation
insights
leads
pharmacologically
prevents
prolyl
promotes
promoting
proteasomal
regulate
repress
stability
suppresses
thereby
turn
usp9x