TREX2 and MESD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TREX2	MESD
Description		three prime repair exonuclease 2	mesoderm development LRP chaperone
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Endoplasmic Reticulum Plasma Membrane
	Molecular Function	Magnesium Ion Binding Nucleic Acid Binding DNA Binding Nuclease Activity Exonuclease Activity Protein Binding 3'-5'-DNA Exonuclease Activity Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity Protein Homodimerization Activity Metal Ion Binding Molecular Adaptor Activity	Protein Binding Identical Protein Binding Protein Folding Chaperone Low-density Lipoprotein Particle Receptor Binding
	Biological Process	DNA Metabolic Process DNA Repair DNA Catabolic Process DNA Damage Response	Ossification Protein Folding Phagocytosis Mesoderm Development Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Protein Localization To Cell Surface Protein Localization To Plasma Membrane Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Pathways
Drugs
Diseases
GWAS
Interacting Genes		4 interacting genes: ATF4 MESD POLD1 UBE2N	78 interacting genes: - ABCG8 ABITRAM ACBD7 AKIRIN2 AKNAD1 AKT1 APP ARB2A ASH2L ATP6V1E1 ATP6V1E2 BORCS8 BORCS8-MEF2B BRD4 C17orf75 CDR2L CENATAC CENPH CHCHD1 CLP1 CNOT9 COL10A1 COL1A2 COX14 COX5A CUTC CYP4F11 DDX6 ENKD1 FAM13C FARS2 FCER1A GEM GOLGA7 GPKOW GTPBP3 H2AB2 H2AB3 HSBP1L1 IGF1 KLHL20 KPNB1 LCE1A LRP5 LY96 MAGEB4 MAP1LC3B MAPDA MCM9 MELTF MKNK2 MRM1 MTNR1A NAA35 NRDE2 PMF1 PSMA5 QARS1 RCOR3 RFC3 SLC6A20 SMARCB1 SNX5 SNX7 TEKTL1 TEX12 TEX48 TPM2 TREX2 TRMT2A TTC21A TTC23 TYMP UBQLN1 ZNF493 ZNF827 ZNF844
Entrez ID		11219	23184
HPRD ID		02299	12129
Ensembl ID		ENSG00000183479	ENSG00000117899
Uniprot IDs		Q9BQ50	Q14696
PDB IDs		1Y97
Enriched GO Terms of Interacting Partners?		Postreplication Repair Lewy Body Core Response To Manganese-induced Endoplasmic Reticulum Stress Cellular Response To UV ATF1-ATF4 Transcription Factor Complex L-asparagine Metabolic Process Response To UV Cellular Response To Light Stimulus Cellular Response To Radiation CHOP-ATF4 Complex Positive Regulation Of Sodium-dependent Phosphate Transport DNA Replication Proofreading UBC13-MMS2 Complex ATF4-CREB1 Transcription Factor Complex Asparagine Metabolic Process Delta DNA Polymerase Complex Ubiquitin Conjugating Enzyme Complex GDF15-GFRAL Signaling Pathway Negative Regulation Of Translational Initiation In Response To Stress Regulation Of Sodium-dependent Phosphate Transport Error-free Translesion Synthesis Cellular Response To Nutrient Levels Nucleotide-excision Repair Complex Nucleotide-excision Repair, DNA Gap Filling HRI-mediated Signaling Lens Fiber Cell Morphogenesis Regulation Of Phosphate Transport Response To Light Stimulus Cellular Response To Manganese Ion Positive Regulation Of Protein K63-linked Ubiquitination Ubiquitin-protein Transferase Activator Activity Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Mitochondrial Respirasome Assembly CAMP Response Element Binding Protein Binding 3'-5'-DNA Exonuclease Activity Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process PERK-mediated Unfolded Protein Response Leucine Zipper Domain Binding General Transcription Initiation Factor Binding Positive Regulation Of Receptor Clustering Cellular Response To Stress Cellular Response To Leucine Starvation Response To Manganese Ion Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Base-excision Repair, Gap-filling Regulation Of Protein K63-linked Ubiquitination Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Nuclear Periphery Response To Radiation	Protein Binding Proton-transporting Two-sector ATPase Complex, Catalytic Domain
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