TREX2 and ATF4

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		TREX2	ATF4
Gene Name		three prime repair exonuclease 2	activating transcription factor 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Dendrite Membrane Nuclear Periphery Neuron Projection Lewy Body Core ATF1-ATF4 Transcription Factor Complex
	Molecular Function	Magnesium Ion Binding Nucleic Acid Binding 3'-5'-exodeoxyribonuclease Activity Exodeoxyribonuclease III Activity Protein Homodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	DNA Catabolic Process, Exonucleolytic DNA Metabolic Process DNA Repair	Gluconeogenesis Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cellular Amino Acid Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Gamma-aminobutyric Acid Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Endoplasmic Reticulum Unfolded Protein Response Circadian Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Cellular Response To Glucose Starvation Positive Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Neuron Apoptotic Process Cellular Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase I Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways			ATF4 activates genes PERK regulates gene expression ATF6-alpha activates chaperones ATF6-alpha activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		2 interactors: ATF4 POLD1	65 interactors: APH1A APP ASB7 ATF2 ATF3 BATF BATF2 BATF3 BFSP2 BTRC CCDC106 CEBPA CEBPB CEBPE CEBPG CKAP4 CREB3 CREBZF DAPK3 DDIT3 DISC1 EGLN3 FOS FOSL1 GABBR2 GCC1 GOLGA1 GOLGA8EP GOLGA8F GPS2 GTF2A1L GTF2B GTF2F2 HAUS7 HK3 JUN JUNB KAT2B LDOC1 LMNB1 MAF MAFB MAP2K7 MDM2 MPZL2 NDC80 NEK6 NFE2 NFE2L1 NFE2L2 NFKBIA POLR2C PTCD3 REPS1 RPS6 SNAP29 SRA1 TBP TGM2 TREX2 TRIB3 TRIM24 TTR ZNF212 ZNF226
Entrez ID		11219	468
HPRD ID		02299	06817
Ensembl ID		ENSG00000183479	ENSG00000128272
Uniprot IDs		Q9BQ50	P18848 Q96AQ3
PDB IDs		1Y97	1CI6
Enriched GO Terms of Interacting Partners?		DNA Replication Proofreading Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Base-excision Repair, Gap-filling Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Transcription From RNA Polymerase I Promoter Fatty Acid Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress DNA Synthesis Involved In DNA Repair Nucleotide-excision Repair, DNA Gap Filling Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Potassium Ion Transport Nuclear DNA Replication Telomere Maintenance Via Recombination Cellular Response To Glucose Starvation Negative Regulation Of Oxidative Stress-induced Cell Death Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Gamma-aminobutyric Acid Signaling Pathway Telomere Maintenance Via Telomere Lengthening Positive Regulation Vascular Endothelial Growth Factor Production DNA Catabolic Process, Exonucleolytic Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Transcription-coupled Nucleotide-excision Repair Anion Homeostasis Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Cellular Response To Oxidative Stress Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Gluconeogenesis Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Potassium Ion Transport Positive Regulation Of Neuron Apoptotic Process Mismatch Repair Base-excision Repair Hexose Biosynthetic Process Positive Regulation Of Neuron Death Telomere Maintenance Circadian Regulation Of Gene Expression Endoplasmic Reticulum Unfolded Protein Response Nucleotide-excision Repair Negative Regulation Of Ion Transport Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway	Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Transcription, DNA-templated RNA Metabolic Process Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To Stress Myeloid Cell Differentiation Leukocyte Differentiation Cellular Metabolic Process Response To Stress Apoptotic Process Cellular Response To Organic Substance Negative Regulation Of Biosynthetic Process Organ Development Myeloid Leukocyte Differentiation Defense Response Programmed Cell Death Immune System Process Response To Stimulus Cell Death Death Hemopoiesis Response To External Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Viral Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?			activates anticancer attenuated autophagy cebpb chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Difference) ?			activates anticancer attenuated autophagy cebpb chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Intersection) ?