TREX2

Gene Name		three prime repair exonuclease 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus
	Molecular Function	Magnesium Ion Binding Nucleic Acid Binding 3'-5'-exodeoxyribonuclease Activity Exodeoxyribonuclease III Activity Protein Homodimerization Activity
	Biological Process	DNA Catabolic Process, Exonucleolytic DNA Metabolic Process DNA Repair
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: ATF4 POLD1
Entrez ID		11219
HPRD ID		02299
Ensembl ID		ENSG00000183479
Uniprot IDs		Q9BQ50
PDB IDs		1Y97
Enriched GO Terms of Interacting Partners?		DNA Replication Proofreading Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Base-excision Repair, Gap-filling Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Transcription From RNA Polymerase I Promoter Fatty Acid Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress DNA Synthesis Involved In DNA Repair Nucleotide-excision Repair, DNA Gap Filling Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Potassium Ion Transport Nuclear DNA Replication Telomere Maintenance Via Recombination Cellular Response To Glucose Starvation Negative Regulation Of Oxidative Stress-induced Cell Death Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Gamma-aminobutyric Acid Signaling Pathway Telomere Maintenance Via Telomere Lengthening Positive Regulation Vascular Endothelial Growth Factor Production DNA Catabolic Process, Exonucleolytic Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Transcription-coupled Nucleotide-excision Repair Anion Homeostasis Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Cellular Response To Oxidative Stress Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Gluconeogenesis Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Potassium Ion Transport Positive Regulation Of Neuron Apoptotic Process Mismatch Repair Base-excision Repair Hexose Biosynthetic Process Positive Regulation Of Neuron Death Telomere Maintenance Circadian Regulation Of Gene Expression Endoplasmic Reticulum Unfolded Protein Response Nucleotide-excision Repair Negative Regulation Of Ion Transport Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway
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