TREX2

Description		three prime repair exonuclease 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	Magnesium Ion Binding Nucleic Acid Binding DNA Binding Nuclease Activity Exonuclease Activity Protein Binding 3'-5'-DNA Exonuclease Activity Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity Protein Homodimerization Activity Metal Ion Binding Molecular Adaptor Activity
	Biological Process	DNA Metabolic Process DNA Repair DNA Catabolic Process DNA Damage Response
Pathways
Drugs
Diseases
GWAS
Interacting Genes		4 interacting genes: ATF4 MESD POLD1 UBE2N
Entrez ID		11219
HPRD ID		02299
Ensembl ID		ENSG00000183479
Uniprot IDs		Q9BQ50
PDB IDs		1Y97
Enriched GO Terms of Interacting Partners?		Postreplication Repair Lewy Body Core Response To Manganese-induced Endoplasmic Reticulum Stress Cellular Response To UV ATF1-ATF4 Transcription Factor Complex L-asparagine Metabolic Process Response To UV Cellular Response To Light Stimulus Cellular Response To Radiation CHOP-ATF4 Complex Positive Regulation Of Sodium-dependent Phosphate Transport DNA Replication Proofreading UBC13-MMS2 Complex ATF4-CREB1 Transcription Factor Complex Asparagine Metabolic Process Delta DNA Polymerase Complex Ubiquitin Conjugating Enzyme Complex GDF15-GFRAL Signaling Pathway Negative Regulation Of Translational Initiation In Response To Stress Regulation Of Sodium-dependent Phosphate Transport Error-free Translesion Synthesis Cellular Response To Nutrient Levels Nucleotide-excision Repair Complex Nucleotide-excision Repair, DNA Gap Filling HRI-mediated Signaling Lens Fiber Cell Morphogenesis Regulation Of Phosphate Transport Response To Light Stimulus Cellular Response To Manganese Ion Positive Regulation Of Protein K63-linked Ubiquitination Ubiquitin-protein Transferase Activator Activity Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Mitochondrial Respirasome Assembly CAMP Response Element Binding Protein Binding 3'-5'-DNA Exonuclease Activity Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process PERK-mediated Unfolded Protein Response Leucine Zipper Domain Binding General Transcription Initiation Factor Binding Positive Regulation Of Receptor Clustering Cellular Response To Stress Cellular Response To Leucine Starvation Response To Manganese Ion Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Base-excision Repair, Gap-filling Regulation Of Protein K63-linked Ubiquitination Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Nuclear Periphery Response To Radiation
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