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CD14 and PPP3R2
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
CD14
PPP3R2
Description
CD14 molecule
protein phosphatase 3 regulatory subunit B, beta
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Golgi Apparatus
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Endosome Membrane
Membrane
Secretory Granule Membrane
Membrane Raft
Lipopolysaccharide Receptor Complex
Extracellular Exosome
Side Of Membrane
Mitochondrion
Cytosol
Calcineurin Complex
Protein Serine/threonine Phosphatase Complex
Sperm Flagellum
Sperm Midpiece
Sperm Mitochondrial Sheath
Molecular Function
Lipopolysaccharide Binding
Opsonin Receptor Activity
Lipopolysaccharide Immune Receptor Activity
Protein Binding
Peptidoglycan Immune Receptor Activity
Lipoteichoic Acid Binding
Molecular Carrier Activity
Calcium Ion Binding
Protein Binding
Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity
Phosphatase Binding
Metal Ion Binding
Biological Process
Positive Regulation Of Cytokine Production
Response To Molecule Of Bacterial Origin
Immune System Process
Cell Surface Pattern Recognition Receptor Signaling Pathway
Receptor-mediated Endocytosis
Phagocytosis
Apoptotic Process
Inflammatory Response
Cell Surface Receptor Signaling Pathway
Response To Bacterium
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Type II Interferon Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
Innate Immune Response
Positive Regulation Of Endocytosis
Cellular Response To Molecule Of Bacterial Origin
Cellular Response To Lipopolysaccharide
Cellular Response To Lipoteichoic Acid
Cellular Response To Diacyl Bacterial Lipopeptide
Cellular Response To Triacyl Bacterial Lipopeptide
Penetration Of Zona Pellucida
Positive Regulation Of Calcineurin-NFAT Signaling Cascade
Calcineurin-mediated Signaling
Positive Regulation Of Calcium Ion Import Across Plasma Membrane
Negative Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways
ER-Phagosome pathway
Caspase activation via Death Receptors in the presence of ligand
Toll Like Receptor 4 (TLR4) Cascade
Transfer of LPS from LBP carrier to CD14
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
MyD88-independent TLR4 cascade
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor TLR6:TLR2 Cascade
TRIF-mediated programmed cell death
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
IKK complex recruitment mediated by RIP1
TRAF6-mediated induction of TAK1 complex within TLR4 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Respiratory syncytial virus (RSV) attachment and entry
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
RSV-host interactions
Drugs
Atibuclimab
Cyclosporine
Voclosporin
Diseases
Asthma
GWAS
Blood protein levels (
30072576
)
Refractive error (
32231278
)
Schizophrenia (
29483656
)
Serum immune biomarker levels (
32066700
)
Interacting Genes
14 interacting genes:
ARFGAP3
CD55
GJB2
IRAK3
ITGB2
LBP
LGALS3BP
LTF
POLR2J
PPP3R2
TLR2
TLR3
TLR4
TNFRSF1B
18 interacting genes:
APC
AURKA
BUB1
CCND1
CD14
DLC1
DYNLL1
FBXW7
KRT34
MLH3
MSH2
PDGFRL
PTPN12
PTPRJ
RAB32
SMAD4
TBC1D10C
TFCP2
Entrez ID
929
5535
HPRD ID
01151
10164
Ensembl ID
ENSG00000170458
ENSG00000188386
Uniprot IDs
P08571
Q96LZ3
PDB IDs
4GLP
Enriched GO Terms of Interacting Partners
?
Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Immune Response
Regulation Of Immune Response
Lipopolysaccharide Binding
Lipopolysaccharide-mediated Signaling Pathway
Regulation Of Cytokine Production Involved In Immune Response
Cellular Response To Lipoteichoic Acid
Toll-like Receptor Signaling Pathway
Regulation Of Cytokine Production
Detection Of Molecule Of Bacterial Origin
Positive Regulation Of Innate Immune Response
Regulation Of Interleukin-6 Production
Macrophage Activation
Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Interleukin-8 Production
Regulation Of Interleukin-12 Production
Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production
Innate Immune Response-activating Signaling Pathway
Defense Response
Positive Regulation Of Chemokine Production
Cell Surface
Regulation Of Production Of Molecular Mediator Of Immune Response
Positive Regulation Of Immune System Process
Activation Of Innate Immune Response
Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus
Activation Of Immune Response
Regulation Of Interleukin-8 Production
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Innate Immune Response
Positive Regulation Of Interleukin-6 Production
Regulation Of Immune System Process
Regulation Of Chemokine Production
Positive Regulation Of Defense Response
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Matrix Metallopeptidase Secretion
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production
Positive Regulation Of Immune Effector Process
Detection Of Biotic Stimulus
Positive Regulation Of Cytokine Production
Regulation Of Defense Response
Negative Regulation Of Osteoclast Differentiation
Regulation Of Toll-like Receptor 4 Signaling Pathway
Inflammatory Response
Myeloid Leukocyte Activation
Defense Response To Bacterium
Response To External Biotic Stimulus
Regulation Of Macrophage Cytokine Production
Positive Regulation Of Interferon-beta Production
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Phase Transition
Centromeric DNA Binding
Kinetochore
Negative Regulation Of Mitotic Cell Cycle
Gamma-catenin Binding
Mismatched DNA Binding
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of ERBB Signaling Pathway
Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
DNA Damage Response
Ruffle Membrane
ATP-dependent DNA Damage Sensor Activity
Negative Regulation Of Cell Cycle Process
Peptidyl-tyrosine Dephosphorylation
Negative Regulation Of Signal Transduction
Regulation Of Programmed Cell Death
Negative Regulation Of Cytoskeleton Organization
Regulation Of Apoptotic Process
Mitotic Spindle Assembly Checkpoint Signaling
Negative Regulation Of Mitotic Metaphase/anaphase Transition
Negative Regulation Of Supramolecular Fiber Organization
Protein-containing Complex Binding
Negative Regulation Of Phosphate Metabolic Process
Response To Stress
Regulation Of Protein Catabolic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Cell Cycle
Negative Regulation Of Cell Communication
Negative Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Nuclear Division
Regulation Of Mitotic Nuclear Division
Regulation Of Cell Cycle
Negative Regulation Of Signaling
Negative Regulation Of Phosphorylation
Mitotic Cell Cycle Phase Transition
Liver Regeneration
Response To UV
Response To X-ray
Cell Cycle Phase Transition
Regeneration
Organelle Organization
Chromosome Organization
Mismatch Repair
Platelet-derived Growth Factor Receptor Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
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