CD14 and LGALS3BP

Number of citations of the paper that reports this interaction (PubMedID 7583357)
0

Data Source:
HPRD (in vitro)

		CD14	LGALS3BP
Description		CD14 molecule	galectin 3 binding protein
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Secretory Granule Membrane Membrane Raft Lipopolysaccharide Receptor Complex Extracellular Exosome Side Of Membrane	Extracellular Region Extracellular Space Membrane Extracellular Matrix Platelet Dense Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Lipopolysaccharide Binding Opsonin Receptor Activity Lipopolysaccharide Immune Receptor Activity Protein Binding Peptidoglycan Immune Receptor Activity Lipoteichoic Acid Binding Molecular Carrier Activity	Scavenger Receptor Activity Protein Binding
	Biological Process	Positive Regulation Of Cytokine Production Response To Molecule Of Bacterial Origin Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Receptor-mediated Endocytosis Phagocytosis Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Response To Bacterium Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Innate Immune Response Positive Regulation Of Endocytosis Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide	Cellular Defense Response Cell Adhesion Signal Transduction Vesicle-mediated Transport
Pathways		ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Respiratory syncytial virus (RSV) attachment and entry Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 RSV-host interactions	Platelet degranulation
Drugs		Atibuclimab
Diseases		Asthma
GWAS		Blood protein levels ( 30072576) Refractive error ( 32231278) Schizophrenia ( 29483656) Serum immune biomarker levels ( 32066700)	Blood protein levels ( 30072576)
Interacting Genes		14 interacting genes: ARFGAP3 CD55 GJB2 IRAK3 ITGB2 LBP LGALS3BP LTF POLR2J PPP3R2 TLR2 TLR3 TLR4 TNFRSF1B	24 interacting genes: CD14 COL5A1 COL6A1 FBXO7 FN1 GALNT6 HSP90AA1 ITGA5 ITGA6 ITGAV ITGB1 LGALS1 LGALS3 NID1 PPIC SELE SIGLEC10 SIGLEC11 SIGLEC5 SIGLEC6 SIGLEC7 SIGLEC9 WNT4 XRN1
Entrez ID		929	3959
HPRD ID		01151	02796
Ensembl ID		ENSG00000170458	ENSG00000108679
Uniprot IDs		P08571	Q08380
PDB IDs		4GLP	1BY2 6GFB
Enriched GO Terms of Interacting Partners?		Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Immune Response Regulation Of Immune Response Lipopolysaccharide Binding Lipopolysaccharide-mediated Signaling Pathway Regulation Of Cytokine Production Involved In Immune Response Cellular Response To Lipoteichoic Acid Toll-like Receptor Signaling Pathway Regulation Of Cytokine Production Detection Of Molecule Of Bacterial Origin Positive Regulation Of Innate Immune Response Regulation Of Interleukin-6 Production Macrophage Activation Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Interleukin-8 Production Regulation Of Interleukin-12 Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Innate Immune Response-activating Signaling Pathway Defense Response Positive Regulation Of Chemokine Production Cell Surface Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of Immune System Process Activation Of Innate Immune Response Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Activation Of Immune Response Regulation Of Interleukin-8 Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Positive Regulation Of Interleukin-6 Production Regulation Of Immune System Process Regulation Of Chemokine Production Positive Regulation Of Defense Response Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Immune Effector Process Detection Of Biotic Stimulus Positive Regulation Of Cytokine Production Regulation Of Defense Response Negative Regulation Of Osteoclast Differentiation Regulation Of Toll-like Receptor 4 Signaling Pathway Inflammatory Response Myeloid Leukocyte Activation Defense Response To Bacterium Response To External Biotic Stimulus Regulation Of Macrophage Cytokine Production Positive Regulation Of Interferon-beta Production Regulation Of Canonical NF-kappaB Signal Transduction	Cell Adhesion Sialic Acid Binding Carbohydrate Binding Wound Healing, Spreading Of Epidermal Cells Cell-matrix Adhesion Laminin Binding Integrin Complex Cell-substrate Adhesion Wound Healing, Spreading Of Cells Response To Muscle Activity Endodermal Cell Differentiation Integrin-mediated Signaling Pathway Proteoglycan Binding Regulation Of Cellular Component Organization Plasma Membrane Extracellular Matrix Cell Surface Cell Migration Integrin Binding Integrin Alpha6-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alphav-beta1 Complex Response To Activity Positive Regulation Of Cell Adhesion Cell Motility Basement Membrane Positive Regulation Of Cell Migration Regulation Of Locomotion Cell Adhesion Mediated By Integrin Regulation Of Cell Adhesion Secretory Granule Membrane Positive Regulation Of Cell Motility Calcium-independent Cell-matrix Adhesion Positive Regulation Of Locomotion Basement Membrane Organization Negative Regulation Of Apoptotic Signaling Pathway Heterotypic Cell-cell Adhesion Neuregulin Binding C-X3-C Chemokine Binding Cell-substrate Junction Assembly Cell-substrate Junction Organization Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Dendritic Cell Differentiation Signaling Receptor Activity Regulation Of Cell Migration Cell-cell Adhesion Mediated By Integrin Extracellular Exosome Endoplasmic Reticulum Lumen Extracellular Region Regulation Of Cell Motility
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