CD14 and ITGB2

Number of citations of the paper that reports this interaction (PMID 11745332)
43

Data Source:
HPRD (in vitro)

		CD14	ITGB2
Gene Name		CD14 molecule	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Endosome Membrane Anchored Component Of Membrane Membrane Raft Extracellular Vesicular Exosome	Plasma Membrane Integrin Complex Cell Surface Membrane Vesicle Integrin AlphaL-beta2 Complex Receptor Complex Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Lipopolysaccharide Binding Opsonin Receptor Activity Protein Binding Peptidoglycan Receptor Activity Lipoteichoic Acid Binding	Glycoprotein Binding Protein Binding Protein Kinase Binding ICAM-3 Receptor Activity Protein Complex Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Phagocytosis Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Response To Heat Response To Magnesium Ion Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Tumor Necrosis Factor TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Response To Ethanol Positive Regulation Of Endocytosis Positive Regulation Of Cytokine Secretion Response To Electrical Stimulus Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid	Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Apoptotic Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Signaling Aging Blood Coagulation Regulation Of Cell Shape Natural Killer Cell Activation Extracellular Matrix Organization Neutrophil Chemotaxis Heterotypic Cell-cell Adhesion Toll-like Receptor 4 Signaling Pathway Endodermal Cell Differentiation Receptor Clustering Endothelial Cell Migration Innate Immune Response Cellular Extravasation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Activated T Cell Proliferation Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		TRAF6 mediated induction of TAK1 complex IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling MyD88-independent cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Transfer of LPS from LBP carrier to CD14 Toll Like Receptor 2 (TLR2) Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88:Mal cascade initiated on plasma membrane TRIF-mediated programmed cell death Innate Immune System	Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Adaptive Immune System Innate Immune System
Drugs			Simvastatin
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ARFGAP3 CD55 GJB2 IRAK3 ITGB2 LBP LGALS3BP LTF POLR2J PPP3R2 TLR2 TLR3 TLR4 TNFRSF1B	41 interactors: CD14 CD226 CD82 COPS3 COPS5 CYTH1 CYTH2 DAB1 DOK1 ESM1 FCER2 FHL2 FUT4 GNB2L1 HP ICAM1 ICAM2 ICAM3 ICAM4 ICAM5 ILK ITGAD ITGAM ITGAX KNG1 NOTCH2NL NUMB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRTN3 PTK2 PTK2B RANBP9 RDX SYK TLN1 VNN2
Entrez ID		929	3689
HPRD ID		01151	02506
Ensembl ID		ENSG00000170458	ENSG00000160255
Uniprot IDs		P08571	A8MYE6 P05107
PDB IDs		4GLP	1JX3 1L3Y 1YUK 2JF1 2P26 2P28 2V7D 3K6S 3K71 3K72
Enriched GO Terms of Interacting Partners?		Regulation Of Tumor Necrosis Factor Production Toll-like Receptor Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Other Organism Response To Biotic Stimulus Macrophage Activation Positive Regulation Of Interleukin-8 Production Regulation Of Interleukin-6 Production Regulation Of Innate Immune Response Response To Bacterium Defense Response Regulation Of Inflammatory Response Positive Regulation Of Immune System Process Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Chemokine Production Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Immune Response Regulation Of Chemokine Production Positive Regulation Of Tumor Necrosis Factor Production Response To Stress Defense Response To Bacterium Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process Inflammatory Response Detection Of Molecule Of Bacterial Origin Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Lipoteichoic Acid Response To External Stimulus I-kappaB Phosphorylation Negative Regulation Of Cytokine Production Innate Immune Response Immune Response Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Inflammatory Response Regulation Of Cytokine Production Positive Regulation Of NF-kappaB Import Into Nucleus Immune System Process Regulation Of Protein Metabolic Process	Blood Coagulation Hemostasis Platelet Activation Cell Activation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Cell Adhesion Regulation Of Immune System Process Regulation Of Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Single Organismal Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Immune System Process Integrin-mediated Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Signal Transduction Defense Response Signal Transduction Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Glial Cell Apoptotic Process Movement Of Cell Or Subcellular Component Locomotion Regulation Of Signaling Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To External Stimulus Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Immune Response Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Immune System Process Positive Regulation Of Phosphorylation Leukocyte Activation Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Activation Of Phospholipase C Activity
Tagcloud ?		1beta 1ra antiinflammatory bmmc ccf cd11b cd16 cd64 cd68 cd95 cholecalciferol explain granulocyte immature immunoassay methotrexate monoblastic monocytic mononuclear mtx oh p75 pbmc rheumatoid sorter stnfr supernatants u937 undifferentiated	a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgal loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly
Tagcloud (Difference) ?		1beta 1ra antiinflammatory bmmc ccf cd11b cd16 cd64 cd68 cd95 cholecalciferol explain granulocyte immature immunoassay methotrexate monoblastic monocytic mononuclear mtx oh p75 pbmc rheumatoid sorter stnfr supernatants u937 undifferentiated	a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgal loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly
Tagcloud (Intersection) ?