CD14 and ARFGAP3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CD14	ARFGAP3
Gene Name		CD14 molecule	ADP-ribosylation factor GTPase activating protein 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Endosome Membrane Anchored Component Of Membrane Membrane Raft Extracellular Vesicular Exosome	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Membrane
	Molecular Function	Lipopolysaccharide Binding Opsonin Receptor Activity Protein Binding Peptidoglycan Receptor Activity Lipoteichoic Acid Binding	Protein Binding ARF GTPase Activator Activity Zinc Ion Binding Protein Transporter Activity
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Phagocytosis Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Response To Heat Response To Magnesium Ion Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Tumor Necrosis Factor TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Response To Ethanol Positive Regulation Of Endocytosis Positive Regulation Of Cytokine Secretion Response To Electrical Stimulus Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid	Intracellular Protein Transport Protein Secretion Vesicle-mediated Transport Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity
Pathways		TRAF6 mediated induction of TAK1 complex IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling MyD88-independent cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Transfer of LPS from LBP carrier to CD14 Toll Like Receptor 2 (TLR2) Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88:Mal cascade initiated on plasma membrane TRIF-mediated programmed cell death Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ARFGAP3 CD55 GJB2 IRAK3 ITGB2 LBP LGALS3BP LTF POLR2J PPP3R2 TLR2 TLR3 TLR4 TNFRSF1B	5 interactors: APP CD14 CXCL8 SMAD2 ZDHHC17
Entrez ID		929	26286
HPRD ID		01151	06444
Ensembl ID		ENSG00000170458	ENSG00000242247
Uniprot IDs		P08571	C9JZR4 Q9NP61
PDB IDs		4GLP	2CRW
Enriched GO Terms of Interacting Partners?		Regulation Of Tumor Necrosis Factor Production Toll-like Receptor Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Other Organism Response To Biotic Stimulus Macrophage Activation Positive Regulation Of Interleukin-8 Production Regulation Of Interleukin-6 Production Regulation Of Innate Immune Response Response To Bacterium Defense Response Regulation Of Inflammatory Response Positive Regulation Of Immune System Process Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Chemokine Production Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Immune Response Regulation Of Chemokine Production Positive Regulation Of Tumor Necrosis Factor Production Response To Stress Defense Response To Bacterium Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process Inflammatory Response Detection Of Molecule Of Bacterial Origin Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Lipoteichoic Acid Response To External Stimulus I-kappaB Phosphorylation Negative Regulation Of Cytokine Production Innate Immune Response Immune Response Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Inflammatory Response Regulation Of Cytokine Production Positive Regulation Of NF-kappaB Import Into Nucleus Immune System Process Regulation Of Protein Metabolic Process	Endocytosis Response To Tumor Necrosis Factor Digestive Tract Development Digestive System Development Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Synaptic Growth At Neuromuscular Junction Cellular Response To Lipopolysaccharide Transport Response To Lipid Cellular Response To Molecule Of Bacterial Origin Signal Transduction Collateral Sprouting In Absence Of Injury Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Zygotic Specification Of Dorsal/ventral Axis Signaling Cell Communication Regulation Of Signal Transduction Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Mesoderm Development Primary MiRNA Processing Regulation Of Signaling Developmental Growth Axon Choice Point Recognition Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Cell Surface Receptor Signaling Pathway Immune Response Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Defense Response Response To Lipopolysaccharide Cellular Response To Stimulus Response To Molecule Of Bacterial Origin Neuron Remodeling Vesicle-mediated Transport SMAD Protein Complex Assembly Paraxial Mesoderm Morphogenesis Cellular Response To Lipoteichoic Acid Cellular Response To Lipid Inflammatory Response Nodal Signaling Pathway Response To Magnesium Ion Posttranscriptional Regulation Of Gene Expression Induction Of Positive Chemotaxis Cellular Copper Ion Homeostasis Response To Bacterium Embryonic Organ Development
Tagcloud ?		1beta 1ra antiinflammatory bmmc ccf cd11b cd16 cd64 cd68 cd95 cholecalciferol explain granulocyte immature immunoassay methotrexate monoblastic monocytic mononuclear mtx oh p75 pbmc rheumatoid sorter stnfr supernatants u937 undifferentiated	accelerated adaptors adp associates cargo cathepsin cation cimpr clathrin copi ear endosomes exit explaining gga ggas golgi mannose perturbed rescued retrograde ribosylation slowed sorting traffic
Tagcloud (Difference) ?		1beta 1ra antiinflammatory bmmc ccf cd11b cd16 cd64 cd68 cd95 cholecalciferol explain granulocyte immature immunoassay methotrexate monoblastic monocytic mononuclear mtx oh p75 pbmc rheumatoid sorter stnfr supernatants u937 undifferentiated	accelerated adaptors adp associates cargo cathepsin cation cimpr clathrin copi ear endosomes exit explaining gga ggas golgi mannose perturbed rescued retrograde ribosylation slowed sorting traffic
Tagcloud (Intersection) ?