CD14 and LBP

Number of citations of the paper that reports this interaction (PubMedID 12417309)
0

Data Source:
HPRD (in vitro)

		CD14	LBP
Description		CD14 molecule	lipopolysaccharide binding protein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Secretory Granule Membrane Membrane Raft Lipopolysaccharide Receptor Complex Extracellular Exosome Side Of Membrane	Extracellular Region Extracellular Space Cell Surface Membrane Extracellular Exosome
	Molecular Function	Lipopolysaccharide Binding Opsonin Receptor Activity Lipopolysaccharide Immune Receptor Activity Protein Binding Peptidoglycan Immune Receptor Activity Lipoteichoic Acid Binding Molecular Carrier Activity	Lipopolysaccharide Binding Signaling Receptor Binding Protein Binding Lipid Binding Coreceptor Activity Lipoteichoic Acid Binding Lipopeptide Binding
	Biological Process	Positive Regulation Of Cytokine Production Response To Molecule Of Bacterial Origin Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Receptor-mediated Endocytosis Phagocytosis Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Response To Bacterium Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Innate Immune Response Positive Regulation Of Endocytosis Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide	Leukocyte Chemotaxis Involved In Inflammatory Response Macrophage Activation Involved In Immune Response Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Lipid Transport Acute-phase Response Cellular Defense Response Opsonization Lipopolysaccharide Transport Neutrophil Chemotaxis Lipopolysaccharide-mediated Signaling Pathway Detection Of Molecule Of Bacterial Origin Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Defense Response To Bacterium Positive Regulation Of Macrophage Activation Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis
Pathways		ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Respiratory syncytial virus (RSV) attachment and entry Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 RSV-host interactions	Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 Regulation of TLR by endogenous ligand Interleukin-4 and Interleukin-13 signaling
Drugs		Atibuclimab
Diseases		Asthma
GWAS		Blood protein levels ( 30072576) Refractive error ( 32231278) Schizophrenia ( 29483656) Serum immune biomarker levels ( 32066700)	Basophil percentage of white cells ( 32888494) Periodontitis (DPAL) ( 24024966)
Interacting Genes		14 interacting genes: ARFGAP3 CD55 GJB2 IRAK3 ITGB2 LBP LGALS3BP LTF POLR2J PPP3R2 TLR2 TLR3 TLR4 TNFRSF1B	18 interacting genes: APOA1 BAG6 BST1 C4BPA CAMP CBFA2T2 CD14 CFHR1 FTH1 HSPB1 PRDX4 PSMA3 PYCR3 RPS21 SETD1A SMAD3 TRA2A TSC22D4
Entrez ID		929	3929
HPRD ID		01151	07175
Ensembl ID		ENSG00000170458	ENSG00000129988
Uniprot IDs		P08571	P18428 Q8TCF0
PDB IDs		4GLP
Enriched GO Terms of Interacting Partners?		Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Immune Response Regulation Of Immune Response Lipopolysaccharide Binding Lipopolysaccharide-mediated Signaling Pathway Regulation Of Cytokine Production Involved In Immune Response Cellular Response To Lipoteichoic Acid Toll-like Receptor Signaling Pathway Regulation Of Cytokine Production Detection Of Molecule Of Bacterial Origin Positive Regulation Of Innate Immune Response Regulation Of Interleukin-6 Production Macrophage Activation Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Interleukin-8 Production Regulation Of Interleukin-12 Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Innate Immune Response-activating Signaling Pathway Defense Response Positive Regulation Of Chemokine Production Cell Surface Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of Immune System Process Activation Of Innate Immune Response Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Activation Of Immune Response Regulation Of Interleukin-8 Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Positive Regulation Of Interleukin-6 Production Regulation Of Immune System Process Regulation Of Chemokine Production Positive Regulation Of Defense Response Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Immune Effector Process Detection Of Biotic Stimulus Positive Regulation Of Cytokine Production Regulation Of Defense Response Negative Regulation Of Osteoclast Differentiation Regulation Of Toll-like Receptor 4 Signaling Pathway Inflammatory Response Myeloid Leukocyte Activation Defense Response To Bacterium Response To External Biotic Stimulus Regulation Of Macrophage Cytokine Production Positive Regulation Of Interferon-beta Production Regulation Of Canonical NF-kappaB Signal Transduction	Regulation Of Interleukin-1 Production Regulation Of Interleukin-1 Beta Production Immune Response Immune System Process Positive Regulation Of Interleukin-1 Production Cytolysis By Host Of Symbiont Cells Positive Regulation Of Interleukin-1 Beta Production Extracellular Region Extracellular Exosome Regulation Of Immune System Process Humoral Immune Response Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Adrenal Gland Development Blood Microparticle Identical Protein Binding Regulation Of Immune Response Killing By Host Of Symbiont Cells Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Response To Other Organism Response To Stress Activation Of Immune Response Lipopolysaccharide Binding Regulation Of Tumor Necrosis Factor Production Prostaglandin Production Involved In Inflammatory Response Biological Process Involved In Interaction With Symbiont Opsonin Receptor Activity Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Humoral Immune Response Positive Regulation Of Stress Fiber Assembly Regulation Of Chemotaxis Tertiary Granule Lumen Regulation Of Cytokine Production Regulation Of Defense Response Protein Stabilization Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Cell-substrate Adhesion Complement Activation Positive Regulation Of Cytokine Production Cellular Response To Butyrate Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Positive Regulation Of Interleukin-8 Production Ferritin Complex Iron Ion Sequestering Activity Proteasome Complex
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