CD14 and GJB2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CD14	GJB2
Description		CD14 molecule	gap junction protein beta 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Secretory Granule Membrane Membrane Raft Lipopolysaccharide Receptor Complex Extracellular Exosome Side Of Membrane	Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction
	Molecular Function	Lipopolysaccharide Binding Opsonin Receptor Activity Lipopolysaccharide Immune Receptor Activity Protein Binding Peptidoglycan Immune Receptor Activity Lipoteichoic Acid Binding Molecular Carrier Activity	Gap Junction Channel Activity Calcium Ion Binding Protein Binding Identical Protein Binding Metal Ion Binding Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling
	Biological Process	Positive Regulation Of Cytokine Production Response To Molecule Of Bacterial Origin Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Receptor-mediated Endocytosis Phagocytosis Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Response To Bacterium Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Innate Immune Response Positive Regulation Of Endocytosis Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide	Cell Communication Cell-cell Signaling Sensory Perception Of Sound Cell Communication By Electrical Coupling Gap Junction Assembly Transmembrane Transport Gap Junction-mediated Intercellular Transport
Pathways		ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Respiratory syncytial virus (RSV) attachment and entry Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 RSV-host interactions	Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly Transport of connexons to the plasma membrane
Drugs		Atibuclimab
Diseases		Asthma	Deafness, autosomal recessive Keratitis-ichthyosis-deafness syndrome Vohwinkel syndrome, including: Vohwinkel syndrome (VS); Vohwinkel syndrome with ichthyosis Deafness, autosomal dominant Palmoplantar keratoderma with deafness
GWAS		Blood protein levels ( 30072576) Refractive error ( 32231278) Schizophrenia ( 29483656) Serum immune biomarker levels ( 32066700)	Facial emotion recognition (happy faces) ( 28608620)
Interacting Genes		14 interacting genes: ARFGAP3 CD55 GJB2 IRAK3 ITGB2 LBP LGALS3BP LTF POLR2J PPP3R2 TLR2 TLR3 TLR4 TNFRSF1B	44 interacting genes: AMIGO1 APLNR AQP6 ARL13B CAV1 CD14 CNST CREB3 EBP ERGIC3 FAM209A FFAR2 GJA5 GJA8 GJB1 GJB6 GPR152 GPR42 HSD17B13 KCNK5 KLRC1 LHFPL5 LMNA LRRC4C MFSD6 MS4A6E PEX12 PLEKHB2 SAR1A SHISAL1 SLC10A6 SLC18A1 SLC30A2 SSMEM1 TBXA2R TEX29 TIMMDC1 TLCD4 TM2D2 TMEM106A TMEM237 TMEM31 TMX2 TRHR
Entrez ID		929	2706
HPRD ID		01151	00413
Ensembl ID		ENSG00000170458	ENSG00000165474
Uniprot IDs		P08571	H9U1J4 P29033
PDB IDs		4GLP	2ZW3 3IZ1 3IZ2 5ER7 5ERA 5KJ3 5KJG 6UVR 6UVS 6UVT 7QEO 7QEQ 7QER 7QES 7QET 7QEU 7QEV 7QEW 7QEY 8Q9Z 8QA0 8QA1 8QA2 8QA3
Enriched GO Terms of Interacting Partners?		Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Immune Response Regulation Of Immune Response Lipopolysaccharide Binding Lipopolysaccharide-mediated Signaling Pathway Regulation Of Cytokine Production Involved In Immune Response Cellular Response To Lipoteichoic Acid Toll-like Receptor Signaling Pathway Regulation Of Cytokine Production Detection Of Molecule Of Bacterial Origin Positive Regulation Of Innate Immune Response Regulation Of Interleukin-6 Production Macrophage Activation Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Interleukin-8 Production Regulation Of Interleukin-12 Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Innate Immune Response-activating Signaling Pathway Defense Response Positive Regulation Of Chemokine Production Cell Surface Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of Immune System Process Activation Of Innate Immune Response Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Activation Of Immune Response Regulation Of Interleukin-8 Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Positive Regulation Of Interleukin-6 Production Regulation Of Immune System Process Regulation Of Chemokine Production Positive Regulation Of Defense Response Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Immune Effector Process Detection Of Biotic Stimulus Positive Regulation Of Cytokine Production Regulation Of Defense Response Negative Regulation Of Osteoclast Differentiation Regulation Of Toll-like Receptor 4 Signaling Pathway Inflammatory Response Myeloid Leukocyte Activation Defense Response To Bacterium Response To External Biotic Stimulus Regulation Of Macrophage Cytokine Production Positive Regulation Of Interferon-beta Production Regulation Of Canonical NF-kappaB Signal Transduction	Membrane Connexin Complex Gap Junction Channel Activity Gap Junction Gap Junction Assembly Protein Binding Plasma Membrane Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Vasoconstriction Connexin Binding Atrioventricular Valve Development Gap Junction-mediated Intercellular Transport Regulation Of Gap Junction Assembly Intercellular Transport G Protein-coupled Receptor Activity Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Muscle System Process Transmembrane Transport Regulation Of Vasoconstriction
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