LZTR1 and L3MBTL3

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		LZTR1	L3MBTL3
Description		leucine zipper like post translational regulator 1	L3MBTL histone methyl-lysine binding protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Golgi Apparatus Endomembrane System Membrane Cul3-RING Ubiquitin Ligase Complex Recycling Endosome Recycling Endosome Membrane	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Binding Small GTPase Binding	Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding Metal Ion Binding Methylation-dependent Protein Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Ras Protein Signal Transduction	Chromatin Organization Regulation Of DNA-templated Transcription Myeloid Cell Differentiation Macrophage Differentiation Granulocyte Differentiation Erythrocyte Maturation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS			A body shape index ( 34021172) Alanine aminotransferase levels ( 34315874 33547301) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 34315874 33547301) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Birth weight ( 27680694 31043758) Body mass index ( 25673413) Breast cancer ( 29058716 29059683) Breast cancer (estrogen-receptor negative) ( 29058716) C-reactive protein levels ( 30388399) Chronic kidney disease ( 31152163) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 31562340 18391951 23563607 25282103 28552196 25429064) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172 25673412 28552196) Immature fraction of reticulocytes ( 32888494) Influenza A (H1N1) infection ( 26379185) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 32888494 27863252) Mild influenza (H1N1) infection ( 26379185) Multiple sclerosis ( 31604244 27386562) Offspring birth weight ( 31043758) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Spleen volume ( 34128465) Triglyceride levels ( 32203549 32154731) Triglyceride levels in HIV infection ( 33109212) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		54 interacting genes: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 GABARAPL2 HCLS1 HDAC4 HRAS IKBKG KDM2B KRAS L3MBTL3 MCM3 MED16 MED7 MYBL2 NR1H3 NRAS PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3	58 interacting genes: ASB6 BANP BYSL C1QTNF4 CRLF3 DEF6 DNMT1 DRC4 FLAD1 FNDC3B FXR2 H3C1 HIF1A HSF2BP IL16 KANK2 KDM1A LIG1 LMO4 LRRK2 LSM4 LZTR1 MAPK3 MAPK9 MFAP1 MORF4L1 MORF4L2 NGB NRF1 NTAQ1 OAZ3 PDE6G PHC2 PHF21A PIK3R3 PLEKHF1 PLEKHF2 PLOD3 POLR2L PPP2CA PRKAA1 PRKAA2 RHOBTB3 SFMBT2 SNRPB SOX2 SP100 SPANXN2 SUFU SUMO1P1 TBC1D1 TCEANC THRA TRAF3IP3 TSTD2 TTC19 ZCWPW1 ZNF76
Entrez ID		8216	84456
HPRD ID		08992	11222
Ensembl ID		ENSG00000099949	ENSG00000198945
Uniprot IDs		A0A384NL67 Q8N653	Q96JM7
PDB IDs			1WJQ 1WJS 3UT1 4FL6 4L59 7RTE 7RTI 8Y76 8Y77
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process DNA Binding Zinc Ion Binding Negative Regulation Of Metabolic Process Transcription By RNA Polymerase II DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nuclear Body Nucleic Acid Metabolic Process Nucleolus Ribonucleoside Binding Transcription Coactivator Activity Chromatin Organization RNA Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex DNA-directed RNA Polymerase Activity Regulation Of DNA-templated Transcription Initiation Chromo Shadow Domain Binding Chromatin Remodeling 5'-3' RNA Polymerase Activity	Protein Binding Nucleus Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Metabolic Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Nuclear Speck Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Glycolytic Process Positive Regulation Of Autophagy Positive Regulation Of Metabolic Process Positive Regulation Of Glycolytic Process Protein Localization To Lipid Droplet Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Carbohydrate Catabolic Process Chromatin Organization Positive Regulation Of Catabolic Process Regulation Of ATP Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Regulation Of Purine Nucleotide Metabolic Process Chromatin Binding TOR Signaling Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Negative Regulation Of TOR Signaling Macromolecule Biosynthetic Process Positive Regulation Of ATP Metabolic Process Regulation Of Programmed Cell Death Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Neuroblast Proliferation Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Phosphatidylethanolamine Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process DNA-templated Transcription Cellular Response To Stress
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