LZTR1 and SUGP2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		LZTR1	SUGP2
Description		leucine zipper like post translational regulator 1	SURP and G-patch domain containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Golgi Apparatus Endomembrane System Membrane Cul3-RING Ubiquitin Ligase Complex Recycling Endosome Recycling Endosome Membrane	Nucleus Nucleoplasm Nuclear Body
	Molecular Function	Protein Binding Small GTPase Binding	Nucleic Acid Binding RNA Binding Protein Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Ras Protein Signal Transduction	RNA Processing MRNA Processing RNA Splicing
Pathways
Drugs
Diseases
GWAS
Interacting Genes		54 interacting genes: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 GABARAPL2 HCLS1 HDAC4 HRAS IKBKG KDM2B KRAS L3MBTL3 MCM3 MED16 MED7 MYBL2 NR1H3 NRAS PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3	61 interacting genes: ATXN1 ATXN1L CEBPA EXOSC8 GOLGA2 GSK3A LZTR1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR128-2 MIR138-2 MIR141 MIR143 MIR155 MIR15B MIR16-1 MIR16-2 MIR17 MIR19A MIR19B1 MIR19B2 MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR34B MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR9-1 MIR9-3 MIR92A1 MIR92A2 MIR93 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PTEN RNF10
Entrez ID		8216	10147
HPRD ID		08992	10469
Ensembl ID		ENSG00000099949	ENSG00000064607
Uniprot IDs		A0A384NL67 Q8N653	A8K5G0 M0R2Z9 Q8IX01
PDB IDs			1X4P
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process DNA Binding Zinc Ion Binding Negative Regulation Of Metabolic Process Transcription By RNA Polymerase II DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nuclear Body Nucleic Acid Metabolic Process Nucleolus Ribonucleoside Binding Transcription Coactivator Activity Chromatin Organization RNA Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex DNA-directed RNA Polymerase Activity Regulation Of DNA-templated Transcription Initiation Chromo Shadow Domain Binding Chromatin Remodeling 5'-3' RNA Polymerase Activity	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Migration Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Locomotion Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Developmental Process Regulation Of Translation Negative Regulation Of Signal Transduction Regulation Of Angiogenesis Extracellular Space Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of MRNA Stability Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of RNA Stability Negative Regulation Of Protein Metabolic Process Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Multicellular Organismal Development
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