WWP1 and ARRDC3

Number of citations of the paper that reports this interaction (PMID 21191027)
22

Data Source:
BioGRID (pull down)

		WWP1	ARRDC3
Gene Name		WW domain containing E3 ubiquitin protein ligase 1	arrestin domain containing 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome	Endosome Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity	Protein Binding Beta-3 Adrenergic Receptor Binding
	Biological Process	Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Transmembrane Transport	Temperature Homeostasis Negative Regulation Of Heat Generation Skin Development Negative Regulation Of Multicellular Organismal Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Fat Pad Development Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Locomotion Involved In Locomotory Behavior
Pathways		Downregulation of ERBB4 signaling Ion channel transport Antigen processing: Ubiquitination & Proteasome degradation Stimuli-sensing channels Class I MHC mediated antigen processing & presentation Signaling by ERBB4 Adaptive Immune System
Drugs
Diseases
GWAS			Breast cancer (prognosis) ( 23319801) Subcutaneous adipose tissue ( 22589738)
Protein-Protein Interactions		47 interactors: ARRDC1 ARRDC2 ARRDC3 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 EWSR1 FAM189A2 FBXL18 H2AFY2 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PTEN RASA1 RNF11 RTN4 SCNN1A SFTPC SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2L3 WBP1 WBP2 YWHAQ ZNF638	14 interactors: BAG3 DCUN1D1 HPGDS ITCH MAGI2 MORF4L1 NEDD4 OTUB2 PDCD6IP STAM2 TNFAIP3 TRIM42 UBE2E2 WWP1
Entrez ID		11059	57561
HPRD ID		03811	09810
Ensembl ID		ENSG00000123124	ENSG00000113369
Uniprot IDs		Q9H0M0	Q96B67
PDB IDs		1ND7 2OP7
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance RNA Metabolic Process Organ Development Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Apoptotic Process Gene Expression Regulation Of Transcription, DNA-templated Programmed Cell Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Death Death Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter System Development Cellular Macromolecule Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Ossification Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Biosynthetic Process Response To Organic Cyclic Compound Positive Regulation Of Cellular Protein Metabolic Process Tube Development Positive Regulation Of Protein Modification Process Multicellular Organismal Development Negative Regulation Of Signaling Tissue Development Cellular Response To Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Response To Growth Factor Nucleobase-containing Compound Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Signal Transduction Developmental Process Positive Regulation Of Ligase Activity Epithelium Development	Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Deubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Interaction With Host Protein K48-linked Deubiquitination Protein K63-linked Deubiquitination Establishment Of Protein Localization To Vacuole Cellular Protein Metabolic Process Proteolysis Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Viral Life Cycle Intracellular Receptor Signaling Pathway Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Signal Transduction Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Viral Entry Into Host Cell Entry Into Host Cell Protein Catabolic Process Negative Regulation Of Signaling Negative Regulation Of Type I Interferon Production Cellular Response To Stimulus Protein Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of CD40 Signaling Pathway Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Transmission Of Virus Development Involved In Symbiotic Interaction Cellular Protein Modification Process Negative Regulation Of Leukocyte Proliferation Cellular Macromolecule Catabolic Process Regulation Of Defense Response To Virus Regulation Of Protein Catabolic Process Tolerance Induction To Lipopolysaccharide Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Osteoclast Proliferation Planar Cell Polarity Pathway Involved In Axis Elongation Regulation Of Cell Cycle Negative Regulation Of Intracellular Signal Transduction Apoptotic Process Protein Deubiquitination
Tagcloud ?		biol chem consisting contains e2 ermekova gavva globin gst hematopoietic heterodimer homologue interacted j ligase motifs multimeric p18 p45 phage ppxy sh3 shen spanning sudol tandem transactivation ubiquitous	adrenergic arrestin arrestins basic beta2 beta2ar capable conformations consists crystal crystallization downregulation electropositive highlights ions ligases lobe lobed motifs nedd4 parallels patch portion ppxy ppyx recruit situation tail thought
Tagcloud (Difference) ?		biol chem consisting contains e2 ermekova gavva globin gst hematopoietic heterodimer homologue interacted j ligase multimeric p18 p45 phage sh3 shen spanning sudol tandem transactivation ubiquitous	adrenergic arrestin arrestins basic beta2 beta2ar capable conformations consists crystal crystallization downregulation electropositive highlights ions ligases lobe lobed nedd4 parallels patch portion ppyx recruit situation tail thought
Tagcloud (Intersection) ?		motifs ppxy