ARRDC3 and HPGDS

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARRDC3	HPGDS
Description		arrestin domain containing 3	hematopoietic prostaglandin D synthase
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Early Endosome Plasma Membrane Membrane	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Beta-3 Adrenergic Receptor Binding	Magnesium Ion Binding Glutathione Transferase Activity Prostaglandin-D Synthase Activity Calcium Ion Binding Protein Binding Transferase Activity Isomerase Activity Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Temperature Homeostasis Protein Transport Heat Generation Negative Regulation Of Heat Generation Positive Regulation Of Hippo Signaling Skin Development Positive Regulation Of Ubiquitin-protein Transferase Activity Fat Pad Development Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Cold-induced Thermogenesis	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Glutathione Metabolic Process Signal Transduction Locomotory Behavior Response To Nematode Response To Selenium Ion Negative Regulation Of Male Germ Cell Proliferation
Pathways			Glutathione conjugation Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs			Glutathione Tretinoin 2-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium Chloride Glutathione disulfide Deoxycholic acid 3-phenyl-5-(1H-pyrazol-3-yl)isoxazole PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE Tranilast 4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid 4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINE Nocodazole 3-(4-nitrophenyl)-1H-pyrazole 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
Diseases
GWAS		Breast cancer ( 25038754 29059683) Breast cancer (prognosis) ( 23319801) Breast cancer (survival) ( 25526632) Platelet distribution width ( 32888494) Subcutaneous adipose tissue ( 22589738)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Blood protein levels ( 30072576) Testicular germ cell tumor ( 23666239 28604728 28604732)
Interacting Genes		36 interacting genes: ADRB2 BAG3 BCL6 CCDC50 CDA DCUN1D1 EFEMP2 EPN2 FAM90A1 HPGDS ITCH MAGI2 MORF4L1 OPTN OTUB2 PDCD6IP PHF1 PRKAA2 RABGEF1 RACK1 RAD18 SMARCD1 STAM2 TNFAIP3 TOLLIP TRIM42 UBA52 UBAC1 UBASH3A UBE2D1 UBE2D2 UBE2E2 UBE2E3 UBQLN2 WWP2 ZRANB1	7 interacting genes: ABHD17A ARRDC3 C14orf39 HK3 LIF MELTF PDE3B
Entrez ID		57561	27306
HPRD ID		09810	04001
Ensembl ID		ENSG00000113369	ENSG00000163106
Uniprot IDs		Q96B67	A0A384P5J0 O60760
PDB IDs		4N7H 4R7V 4R7X	1IYH 1IYI 1V40 2CVD 2VCQ 2VCW 2VCX 2VCZ 2VD0 2VD1 3EE2 3KXO 3VI5 3VI7 4EC0 4EDY 4EDZ 4EE0 5AIS 5AIV 5AIX 5YWE 5YWX 5YX1 6N4E 6W58 6W8H 6ZTC 7JR6 7JR8
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Polyubiquitin Modification-dependent Protein Binding Protein Modification Process Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Metabolic Process Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Autophagy Negative Regulation Of Signal Transduction Cytosol Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Monoubiquitination Ubiquitin Protein Ligase Activity Macromolecule Metabolic Process Protein Autoubiquitination Positive Regulation Of Catabolic Process Protein K63-linked Ubiquitination Endosome Negative Regulation Of Intracellular Signal Transduction Protein K63-linked Deubiquitination K63-linked Polyubiquitin Modification-dependent Protein Binding Proteolysis Regulation Of Macroautophagy Positive Regulation Of Macroautophagy Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ubiquitin Binding Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Gene Expression Nucleoplasm Regulation Of Germinal Center Formation Cytoplasm Regulation Of Post-translational Protein Modification Modification-dependent Protein Catabolic Process Protein Binding Positive Regulation Of Protein Metabolic Process Protein K11-linked Deubiquitination Nucleus Regulation Of Protein Modification Process Catabolic Process Negative Regulation Of Endocytosis Positive Regulation Of Autophagy Receptor-mediated Endocytosis Regulation Of Signal Transduction Tolerance Induction Cellular Response To Unfolded Protein	Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Heat Generation Hexokinase Activity Mannokinase Activity Glucokinase Activity Fructokinase Activity Leukemia Inhibitory Factor Signaling Pathway Leukemia Inhibitory Factor Receptor Binding Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Locomotion Involved In Locomotory Behavior Beta-3 Adrenergic Receptor Binding Negative Regulation Of Protein Localization To Microtubule Meiotic DNA Double-strand Break Processing Involved In Reciprocal Meiotic Recombination Meiotic DNA Double-strand Break Processing Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Postsynaptic Recycling Endosome Membrane Protein Depalmitoylation Positive Regulation Of Protein Metabolic Process Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Cell Adhesion Muscle Organ Morphogenesis Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Lung Lobe Morphogenesis Positive Regulation Of Plasminogen Activation Guanyl-nucleotide Exchange Factor Complex Regulation Of Locomotion Involved In Locomotory Behavior Heat Generation Central Element
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