ARRDC3 and STAM2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARRDC3	STAM2
Description		arrestin domain containing 3	signal transducing adaptor molecule 2
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GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Early Endosome Plasma Membrane Membrane	Nucleoplasm Cytoplasm Endosome Cytosol Membrane Endocytic Vesicle Early Endosome Membrane ESCRT-0 Complex
	Molecular Function	Protein Binding Beta-3 Adrenergic Receptor Binding	Protein Binding Phosphatidylinositol Binding Ubiquitin Binding
	Biological Process	Temperature Homeostasis Protein Transport Heat Generation Negative Regulation Of Heat Generation Positive Regulation Of Hippo Signaling Skin Development Positive Regulation Of Ubiquitin-protein Transferase Activity Fat Pad Development Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Cold-induced Thermogenesis	Signal Transduction Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission
Pathways			EGFR downregulation Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS		Breast cancer ( 25038754 29059683) Breast cancer (prognosis) ( 23319801) Breast cancer (survival) ( 25526632) Platelet distribution width ( 32888494) Subcutaneous adipose tissue ( 22589738)	Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Metabolic syndrome ( 31170924) Pulse pressure ( 30224653)
Interacting Genes		36 interacting genes: ADRB2 BAG3 BCL6 CCDC50 CDA DCUN1D1 EFEMP2 EPN2 FAM90A1 HPGDS ITCH MAGI2 MORF4L1 OPTN OTUB2 PDCD6IP PHF1 PRKAA2 RABGEF1 RACK1 RAD18 SMARCD1 STAM2 TNFAIP3 TOLLIP TRIM42 UBA52 UBAC1 UBASH3A UBE2D1 UBE2D2 UBE2E2 UBE2E3 UBQLN2 WWP2 ZRANB1	37 interacting genes: ABI2 ARRDC3 ATXN1 CBX5 CDC7 DAZAP2 EGFR ENTREP1 EPS15 HGS ITCH JAK1 JAK2 JAK3 KLHL42 L3MBTL2 LCP2 LITAF MAP3K1 PHF10 PLEKHB2 PTPN1 RNF11 SH2D4A STAMBP TIMM8A TYK2 UBE2D1 UBE2D2 UBE2D3 UBE2H UBQLN1 UBQLN4 USP8 VPS37C XRN1 ZC3H10
Entrez ID		57561	10254
HPRD ID		09810	05876
Ensembl ID		ENSG00000113369	ENSG00000115145
Uniprot IDs		Q96B67	O75886
PDB IDs		4N7H 4R7V 4R7X	1X2Q 1X5B 2L0T 5CRV 5IXF
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Polyubiquitin Modification-dependent Protein Binding Protein Modification Process Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Metabolic Process Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Autophagy Negative Regulation Of Signal Transduction Cytosol Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Monoubiquitination Ubiquitin Protein Ligase Activity Macromolecule Metabolic Process Protein Autoubiquitination Positive Regulation Of Catabolic Process Protein K63-linked Ubiquitination Endosome Negative Regulation Of Intracellular Signal Transduction Protein K63-linked Deubiquitination K63-linked Polyubiquitin Modification-dependent Protein Binding Proteolysis Regulation Of Macroautophagy Positive Regulation Of Macroautophagy Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ubiquitin Binding Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Gene Expression Nucleoplasm Regulation Of Germinal Center Formation Cytoplasm Regulation Of Post-translational Protein Modification Modification-dependent Protein Catabolic Process Protein Binding Positive Regulation Of Protein Metabolic Process Protein K11-linked Deubiquitination Nucleus Regulation Of Protein Modification Process Catabolic Process Negative Regulation Of Endocytosis Positive Regulation Of Autophagy Receptor-mediated Endocytosis Regulation Of Signal Transduction Tolerance Induction Cellular Response To Unfolded Protein	Endosome Growth Hormone Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Binding Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Early Endosome Proteolysis Cell Surface Receptor Signaling Pathway Via STAT Extrinsic Component Of Plasma Membrane Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Protein Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Protein K48-linked Ubiquitination Protein-containing Complex Cytoplasmic Side Of Plasma Membrane Negative Regulation Of Signal Transduction Early Endosome Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Type II Interferon-mediated Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of Cell Communication Protein Tyrosine Kinase Activity Negative Regulation Of Signaling Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Interleukin-12 Receptor Complex Ubiquitin-protein Transferase Activity Protein Autoubiquitination Receptor Internalization Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Macromolecule Metabolic Process Catabolic Process Interleukin-23 Receptor Complex Cytosol Protein Polyubiquitination Endosome Membrane Regulation Of Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Proteasomal Protein Catabolic Process Interleukin-23-mediated Signaling Pathway Positive Regulation Of NK T Cell Proliferation CXCL12-activated CXCR4 Signaling Pathway
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