NR4A3 and SIX3

Number of citations of the paper that reports this interaction (PubMedID 15523651)
0

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, in vivo)

		NR4A3	SIX3
Description		nuclear receptor subfamily 4 group A member 3	SIX homeobox 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Histone Acetyltransferase Binding Nuclear Glucocorticoid Receptor Binding CAMP Response Element Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mesoderm Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Gastrulation Axon Guidance Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of D-glucose Transmembrane Transport Hippocampus Development Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Adult Behavior Positive Regulation Of Mast Cell Cytokine Production Smooth Muscle Cell Apoptotic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process Intracellular Signal Transduction Common Myeloid Progenitor Cell Proliferation Positive Regulation Of Mast Cell Activation By Fc-epsilon Receptor Signaling Pathway Inner Ear Morphogenesis Response To Hydrogen Peroxide Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Cellular Response To Leptin Stimulus Cellular Respiration Fat Cell Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Semicircular Canal Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Neuromuscular Process Controlling Balance Neuron Apoptotic Process Vestibular Reflex Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Corticotropin-releasing Hormone Stimulus Cellular Response To Catecholamine Stimulus Energy Homeostasis Dendritic Cell Apoptotic Process Positive Regulation Of Monocyte Aggregation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Feeding Behavior Positive Regulation Of Dendritic Cell Apoptotic Process	Eye Development Epithelial Cell Maturation Lens Development In Camera-type Eye Optic Vesicle Morphogenesis Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Brain Development Visual Perception Gonad Development Proximal/distal Axis Specification Neuroblast Differentiation Diencephalon Development Telencephalon Development Forebrain Anterior/posterior Pattern Specification Forebrain Dorsal/ventral Pattern Formation Cell Proliferation In Forebrain Telencephalon Regionalization Pituitary Gland Development Negative Regulation Of Wnt Signaling Pathway Thyroid Gland Development Multicellular Organism Growth Regulation Of Cell Population Proliferation Camera-type Eye Development Negative Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Circadian Behavior Lens Induction In Camera-type Eye Regulation Of Neural Retina Development Lens Fiber Cell Differentiation Neuroblast Migration Regulation Of Cell Cycle Phase Transition Regulation Of Neuroblast Proliferation Apoptotic Process Involved In Development Lens Fiber Cell Apoptotic Process Regulation Of Neural Precursor Cell Proliferation
Pathways		RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs		Dasatinib
Diseases		Extraskeletal myxoid chondrosarcoma	Holoprosencephaly (HPE)
GWAS		Dental caries ( 23064961) Depression in smokers ( 30219690) Eosinophil percentage of white cells ( 32888494) Lung cancer ( 28604730) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 34127860)	Adventurousness ( 30643258) Age at first sexual intercourse ( 34211149) Alcohol and nicotine co-dependence ( 22488850) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30679032 30643258) Alcohol use disorder ( 30940813) Blood sugar levels ( 29403010) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Clozapine-induced myocarditis in schizophrenia ( 32066683) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fasting blood glucose ( 29621232 33842983) Fasting glucose ( 34059833) Fasting plasma glucose ( 25187374) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) General risk tolerance (MTAG) ( 30643258) Glycated hemoglobin levels ( 29170429 34059833) Hemoglobin A1c levels ( 29403010) Intraocular pressure ( 30054594 29785010 31959993) Irritable mood ( 29500382) Lung cancer ( 28604730) Metabolite levels ( 21909109) Myopia ( 27182965) Optic disc size ( 31809533) Problematic alcohol use ( 32451486) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Self-reported risk-taking behaviour ( 30271922) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 32499647)
Interacting Genes		43 interacting genes: ADAMTSL4 ALPP CDKN2D CHRD COPS5 CYP21A2 CYSRT1 EFEMP1 HSD3B7 KPRP KRTAP10-1 KRTAP10-5 KRTAP10-8 KRTAP12-3 KRTAP12-4 KRTAP4-11 KRTAP4-2 KRTAP4-4 KRTAP5-11 KRTAP5-3 KRTAP5-6 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2B LCE2D MACO1 NECTIN2 PCSK5 PIN1 RECK RPS6KA1 SIX3 SMOC1 TRIM28 TSPAN4 UBE3A VASN VHL VWC2L ZNF330	8 interacting genes: EYA1 GMNN NR4A3 OTUD3 PAX6 TLE1 TLE3 TLE5
Entrez ID		8013	6496
HPRD ID		02766	04756
Ensembl ID		ENSG00000119508	ENSG00000138083
Uniprot IDs		Q92570	O95343
PDB IDs		8XTT
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Hair Cycle Epidermis Development Embryo Implantation	Transcription Corepressor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Animal Organ Morphogenesis Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Semicircular Canal Morphogenesis Negative Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Beta-catenin-TCF Complex Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Anoikis Histone Acetyltransferase Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Transcription Regulator Complex Negative Regulation Of Signal Transduction Regulation Of Canonical Wnt Signaling Pathway Regulation Of Metabolic Process Wnt Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signaling Inner Ear Morphogenesis Regulation Of Wnt Signaling Pathway Negative Regulation Of Metabolic Process Nucleus Otic Vesicle Morphogenesis Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Positive Regulation Of Mast Cell Activation By Fc-epsilon Receptor Signaling Pathway Energy Homeostasis Regulation Of Epithelial Cell Proliferation Cell Fate Specification Embryonic Morphogenesis Positive Regulation Of Monocyte Aggregation Vestibular Reflex Developmental Process Histone H2AXY142 Phosphatase Activity Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Habenula Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?