NR4A3 and KRTAP6-3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NR4A3	KRTAP6-3
Description		nuclear receptor subfamily 4 group A member 3	keratin associated protein 6-3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Cytosol Intermediate Filament
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Histone Acetyltransferase Binding Nuclear Glucocorticoid Receptor Binding CAMP Response Element Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mesoderm Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Gastrulation Axon Guidance Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of D-glucose Transmembrane Transport Hippocampus Development Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Adult Behavior Positive Regulation Of Mast Cell Cytokine Production Smooth Muscle Cell Apoptotic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process Intracellular Signal Transduction Common Myeloid Progenitor Cell Proliferation Positive Regulation Of Mast Cell Activation By Fc-epsilon Receptor Signaling Pathway Inner Ear Morphogenesis Response To Hydrogen Peroxide Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Cellular Response To Leptin Stimulus Cellular Respiration Fat Cell Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Semicircular Canal Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Neuromuscular Process Controlling Balance Neuron Apoptotic Process Vestibular Reflex Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Corticotropin-releasing Hormone Stimulus Cellular Response To Catecholamine Stimulus Energy Homeostasis Dendritic Cell Apoptotic Process Positive Regulation Of Monocyte Aggregation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Feeding Behavior Positive Regulation Of Dendritic Cell Apoptotic Process	Keratinization
Pathways		RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs		Dasatinib
Diseases		Extraskeletal myxoid chondrosarcoma
GWAS		Dental caries ( 23064961) Depression in smokers ( 30219690) Eosinophil percentage of white cells ( 32888494) Lung cancer ( 28604730) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 34127860)
Interacting Genes		43 interacting genes: ADAMTSL4 ALPP CDKN2D CHRD COPS5 CYP21A2 CYSRT1 EFEMP1 HSD3B7 KPRP KRTAP10-1 KRTAP10-5 KRTAP10-8 KRTAP12-3 KRTAP12-4 KRTAP4-11 KRTAP4-2 KRTAP4-4 KRTAP5-11 KRTAP5-3 KRTAP5-6 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2B LCE2D MACO1 NECTIN2 PCSK5 PIN1 RECK RPS6KA1 SIX3 SMOC1 TRIM28 TSPAN4 UBE3A VASN VHL VWC2L ZNF330	160 interacting genes: ADAMTSL4 AGXT ARID5A ARMC7 ATOSB ATPAF2 AUTS2 BAG4 BEX2 BSCL2 C11orf87 CAMK2A CAMK2B CAMK2G CARHSP1 CCDC120 CCDC24 CCER1 CELF5 CHRD CLCNKA CNNM3 COL8A1 CREB5 CRY2 CTSZ CYSRT1 DALRD3 DHRS1 DMRT3 FADS6 FAM83A FBXW5 FCHO1 FOXD2 FOXD4L1 GATA2 GATA3 GLYCTK GNE GPS2 HAPLN2 HHEX HOXA1 HOXB5 HOXB9 HOXC8 HR HYAL2 ILF2 INCA1 INPP5D ITGB4 KANK2 KPRP KRT20 KRTAP11-1 KRTAP12-2 KRTAP19-2 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP26-1 KRTAP4-4 KRTAP6-1 KRTAP6-2 LAGE3 LCE1A LCE1B LCE1C LCE1E LCE1F LCE2A LCE2B LCE2C LCE3A LCE3C LCE3D LCE3E LCE5A LGALS9 LNX1 MAGED1 MAPK1IP1L MAPKBP1 MBD3L2 MED25 MEIS2 MEOX2 MGAT5B NODAL NOTO NR4A3 OLIG3 OTX1 OXER1 P4HB PATZ1 PCDHB14 PGAP6 PHETA1 PHLDA1 PIGS PITX1 PLSCR4 POU4F2 POU4F3 PPP1R37 PRMT8 PROP1 PRPF31 PRR13 PRR3 PRR35 PSMA1 PVR RAB3IL1 RAD54L2 RASD1 RHBDL1 RUNX1T1 SAMD7 SAXO4 SAXO5 SEMA4C SH3KBP1 SLC15A2 SLC22A5 SMARCC1 SMARCE1 SMCP SNRPB SNRPC SNX18 STK16 STRA6 TAOK2 TBX2 TBX6 TCAF1 TCF7L2 TEKT4 TENT2 TFAP2D TLE5 TLX3 TNIP1 TNS2 TSPYL6 TYK2 VASN VENTX VSTM4 WDR25 ZBTB32 ZIC1 ZNF414 ZNF497 ZNF575 ZNF79
Entrez ID		8013	337968
HPRD ID		02766	11220
Ensembl ID		ENSG00000119508	ENSG00000212938
Uniprot IDs		Q92570
PDB IDs		8XTT
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Hair Cycle Epidermis Development Embryo Implantation	Protein Binding Keratinization Epidermis Development Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Tissue Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription DNA Binding Developmental Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Calcium- And Calmodulin-dependent Protein Kinase Complex Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Inner Ear Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process System Development Transcription Regulator Complex Pattern Specification Process Cell Fate Specification Regulation Of Gene Expression Anatomical Structure Morphogenesis Embryonic Morphogenesis Regulation Of Primary Metabolic Process Embryonic Pattern Specification Myoblast Fate Commitment SnRNP Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
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