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MAP2K2 and ZNF207
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
MAP2K2
ZNF207
Gene Name
mitogen-activated protein kinase kinase 2
zinc finger protein 207
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Nucleus
Cytoplasm
Mitochondrion
Early Endosome
Late Endosome
Peroxisomal Membrane
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Microtubule
Cell-cell Junction
Focal Adhesion
Cell Cortex
Cytoplasmic Side Of Plasma Membrane
Perinuclear Region Of Cytoplasm
Kinetochore
Condensed Chromosome Kinetochore
Nucleus
Nucleolus
Microtubule
Molecular Function
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
PDZ Domain Binding
Protein Complex Scaffold
Protein Serine/threonine Kinase Activator Activity
Scaffold Protein Binding
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Microtubule Binding
Heparin Binding
Zinc Ion Binding
Poly(A) RNA Binding
Biological Process
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Ras Protein Signal Transduction
Axon Guidance
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Pathogenesis
Peptidyl-tyrosine Phosphorylation
Regulation Of Stress-activated MAPK Cascade
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Peptidyl-serine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Innate Immune Response
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Stress-activated MAPK Cascade
ERK1 And ERK2 Cascade
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Golgi Inheritance
Positive Regulation Of Cell Motility
Regulation Of Early Endosome To Late Endosome Transport
Mitotic Sister Chromatid Segregation
Regulation Of Transcription, DNA-templated
Mitotic Spindle Assembly Checkpoint
Attachment Of Spindle Microtubules To Kinetochore
Protein Stabilization
Cell Division
Regulation Of Chromosome Segregation
Pathways
Signaling by GPCR
Signaling by FGFR in disease
MEK activation
FCERI mediated MAPK activation
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
SHC1 events in ERBB2 signaling
Toll Like Receptor TLR1:TLR2 Cascade
DAP12 signaling
Uptake and actions of bacterial toxins
Toll Like Receptor 5 (TLR5) Cascade
Gastrin-CREB signalling pathway via PKC and MAPK
MyD88 dependent cascade initiated on endosome
Toll Like Receptor 9 (TLR9) Cascade
SOS-mediated signalling
Uptake and function of anthrax toxins
SHC-mediated signalling
Signaling by PDGF
DAP12 interactions
TRIF-mediated TLR3/TLR4 signaling
SHC-related events triggered by IGF1R
GRB2 events in EGFR signaling
Signaling by ERBB4
Toll Like Receptor 2 (TLR2) Cascade
Signaling by ERBB2
Signaling by EGFR
Signaling by Interleukins
SHC1 events in ERBB4 signaling
Signaling by VEGF
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Signalling to RAS
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
Interleukin-2 signaling
Frs2-mediated activation
Signaling by Leptin
Signalling to ERKs
Prolonged ERK activation events
ERK activation
Axon guidance
IRS-mediated signalling
Toll Like Receptor 7/8 (TLR7/8) Cascade
L1CAM interactions
IGF1R signaling cascade
Toll Like Receptor TLR6:TLR2 Cascade
VEGFA-VEGFR2 Pathway
Activated TLR4 signalling
IRS-related events triggered by IGF1R
MyD88 cascade initiated on plasma membrane
VEGFR2 mediated cell proliferation
GRB2 events in ERBB2 signaling
ERK activation
RAF phosphorylates MEK
Downstream signaling of activated FGFR
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88:Mal cascade initiated on plasma membrane
NCAM signaling for neurite out-growth
RAF/MAP kinase cascade
Signalling to p38 via RIT and RIN
Signaling by Insulin receptor
Innate Immune System
Signalling by NGF
Signal transduction by L1
Insulin receptor signalling cascade
SOS-mediated signalling
MAP kinase activation in TLR cascade
SHC-mediated signalling
Cytokine Signaling in Immune system
IRS-related events
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
SHC-related events
MyD88-independent cascade
Signaling by Overexpressed Wild-Type EGFR in Cancer
ERK2 activation
Signaling by FGFR
ARMS-mediated activation
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
SHC1 events in EGFR signaling
IRS-mediated signalling
FRS2-mediated cascade
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
ERK2 activation
Drugs
Diseases
GWAS
Protein-Protein Interactions
18 interactors:
ARAF
BRAF
CASP9
CCNDBP1
CNKSR1
COPS5
DUSP3
FAM65B
GRIN1
GRIN2D
LAMTOR3
LIG4
MAPK1
MAPK3
MAPK8
RAF1
RGS12
ZNF207
8 interactors:
BUB3
ERBB3
HNRNPM
HNRNPUL1
MAP2K2
POLR1B
WBP4
WDR77
Entrez ID
5605
7756
HPRD ID
03164
04576
Ensembl ID
ENSG00000126934
ENSG00000010244
Uniprot IDs
B3KS97
P36507
O43670
PDB IDs
1S9I
4H3Q
Enriched GO Terms of Interacting Partners
?
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
MAPK Cascade
Signal Transduction By Phosphorylation
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Cellular Response To Growth Factor Stimulus
Fibroblast Growth Factor Receptor Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Response To Growth Factor
Activation Of MAPKK Activity
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Intracellular Signal Transduction
MyD88-dependent Toll-like Receptor Signaling Pathway
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Toll-like Receptor 4 Signaling Pathway
Response To Abiotic Stimulus
Fc-epsilon Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Toll-like Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Regulation Of Signaling
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Regulation Of Golgi Inheritance
Response To Metal Ion
Cellular Response To Inorganic Substance
Activation Of Innate Immune Response
Regulation Of Cellular Protein Metabolic Process
Regulation Of MAPK Cascade
Caveolin-mediated Endocytosis
Positive Regulation Of Metabolic Process
Epidermal Growth Factor Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
ERBB Signaling Pathway
Positive Regulation Of Catalytic Activity
Regulation Of Signal Transduction
Regulation Of Cellular Amino Acid Metabolic Process
Positive Regulation Of Innate Immune Response
Regulation Of Protein Metabolic Process
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
RNA Splicing
MRNA Processing
MRNA Metabolic Process
RNA Processing
Nucleologenesis
Cellular Metabolic Process
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Golgi Inheritance
Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development
ERBB Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
RNA Metabolic Process
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Nucleolus Organization
Neurotrophin TRK Receptor Signaling Pathway
Peptidyl-serine Autophosphorylation
Neurotrophin Signaling Pathway
Gene Expression
Fc-epsilon Receptor Signaling Pathway
Regulation Of Golgi Organization
Fc Receptor Signaling Pathway
Attachment Of Spindle Microtubules To Kinetochore
Peptidyl-tyrosine Phosphorylation
Regulation Of Early Endosome To Late Endosome Transport
Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Tagcloud
?
acclimatized
adra1d
altitude
araf
argef11
arhgap24
ascent
cardiogenic
circuitry
cldn23
cldn6
ece1
ednra
genic
hape
inciting
mapk10
mylk
oxphos
pak3
pathoetiology
plcb1
pxn
skew
sos1
unacclimatized
vasoconstriction
vcam1
Tagcloud (Difference)
?
acclimatized
adra1d
altitude
araf
argef11
arhgap24
ascent
cardiogenic
circuitry
cldn23
cldn6
ece1
ednra
genic
hape
inciting
mapk10
mylk
oxphos
pak3
pathoetiology
plcb1
pxn
skew
sos1
unacclimatized
vasoconstriction
vcam1
Tagcloud (Intersection)
?