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MAP2K2
Description
mitogen-activated protein kinase kinase 2
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Cytoplasm
Mitochondrion
Early Endosome
Late Endosome
Peroxisomal Membrane
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Microtubule
Cell-cell Junction
Focal Adhesion
Cytoplasmic Side Of Plasma Membrane
Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
MAP-kinase Scaffold Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
PDZ Domain Binding
Protein Serine/threonine Kinase Activator Activity
Metal Ion Binding
Molecular Adaptor Activity
Scaffold Protein Binding
Protein Serine Kinase Activity
Biological Process
MAPK Cascade
Heart Development
Positive Regulation Of Gene Expression
Schwann Cell Development
Thyroid Gland Development
Regulation Of Stress-activated MAPK Cascade
Peptidyl-serine Autophosphorylation
ERBB2-ERBB3 Signaling Pathway
Myelination
Positive Regulation Of DNA-templated Transcription
Insulin-like Growth Factor Receptor Signaling Pathway
Thymus Development
Regulation Of Axon Regeneration
Positive Regulation Of Axonogenesis
Face Development
Lung Morphogenesis
Trachea Formation
Epithelial Cell Proliferation Involved In Lung Morphogenesis
ERK1 And ERK2 Cascade
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Golgi Inheritance
Positive Regulation Of Cell Motility
Regulation Of Early Endosome To Late Endosome Transport
Pathways
MAPK1 (ERK2) activation
Frs2-mediated activation
Signal transduction by L1
Uptake and function of anthrax toxins
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by MAP2K mutants
Signaling by RAF1 mutants
Drugs
Bosutinib
Trametinib
Selumetinib
Binimetinib
Fostamatinib
Pimasertib
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Eosinophil count (
32888494
)
Heel bone mineral density (
30598549
)
Height (
29782485
)
Lymphocyte count (
32888494
)
Pulse pressure (
30224653
)
White blood cell count (
32888494
)
Interacting Genes
20 interacting genes:
ARAF
BRAF
CASP9
CCNDBP1
CNKSR1
COPS5
DUSP3
GRIN1
GRIN2D
HNRNPK
LAMTOR3
LIG4
MAPK1
MAPK3
MAPK8
MOS
RAF1
RGS12
RIPOR2
ZNF207
Entrez ID
5605
HPRD ID
03164
Ensembl ID
ENSG00000126934
Uniprot IDs
B3KS97
P36507
PDB IDs
1S9I
4H3Q
Enriched GO Terms of Interacting Partners
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MAPK Cascade
MAP Kinase Kinase Kinase Activity
Face Development
Thyroid Gland Development
Intracellular Signal Transduction
Protein Serine Kinase Activity
ERBB3 Signaling Pathway
ERBB2-ERBB3 Signaling Pathway
Intracellular Signaling Cassette
Protein Serine/threonine Kinase Activity
Thymus Development
Regulation Of Signal Transduction
Regulation Of MAPK Cascade
MAP Kinase Activity
Pseudopodium
Protein Kinase Activity
Schwann Cell Development
ERBB Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Peptidyl-serine Phosphorylation
Stress-activated MAPK Cascade
ERBB2 Signaling Pathway
Regulation Of Intracellular Signal Transduction
Stress-activated Protein Kinase Signaling Cascade
Signal Transduction
Kinase Activity
Interleukin-34-mediated Signaling Pathway
Hematopoietic Or Lymphoid Organ Development
Regulation Of Peptidyl-serine Phosphorylation
Cytoplasm
Regulation Of Chromosome Organization
Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Golgi Inheritance
Caveolin-mediated Endocytosis
Positive Regulation Of Macrophage Proliferation
Positive Regulation Of Synaptic Transmission
NMDA Glutamate Receptor Activity
Glutamate Binding
Cardiac Neural Crest Cell Development Involved In Heart Development
Trachea Formation
Regulation Of Granulocyte Chemotaxis
Response To Epidermal Growth Factor
Negative Regulation Of Apoptotic Process
ERK1 And ERK2 Cascade
Long-term Synaptic Potentiation
Protein Phosphorylation
Negative Regulation Of Programmed Cell Death
NMDA Selective Glutamate Receptor Complex
Glutamate-gated Calcium Ion Channel Activity
Tagcloud
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