MAP2K2 and ARAF

Number of citations of the paper that reports this interaction (PMID 11909642)
1

Data Source:
HPRD (two hybrid, in vitro)

		MAP2K2	ARAF
Gene Name		mitogen-activated protein kinase kinase 2	A-Raf proto-oncogene, serine/threonine kinase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Early Endosome Late Endosome Peroxisomal Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule Cell-cell Junction Focal Adhesion Cell Cortex Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm	Cellular_component
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding PDZ Domain Binding Protein Complex Scaffold Protein Serine/threonine Kinase Activator Activity Scaffold Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Peptidyl-tyrosine Phosphorylation Regulation Of Stress-activated MAPK Cascade Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Peptidyl-serine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Golgi Inheritance Positive Regulation Of Cell Motility Regulation Of Early Endosome To Late Endosome Transport	Cellular Protein Modification Process Protein Phosphorylation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Negative Regulation Of Apoptotic Process
Pathways		Signaling by GPCR Signaling by FGFR in disease MEK activation FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Uptake and actions of bacterial toxins Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade SOS-mediated signalling Uptake and function of anthrax toxins SHC-mediated signalling Signaling by PDGF DAP12 interactions TRIF-mediated TLR3/TLR4 signaling SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Signalling to RAS Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Signalling to ERKs Prolonged ERK activation events ERK activation Axon guidance IRS-mediated signalling Toll Like Receptor 7/8 (TLR7/8) Cascade L1CAM interactions IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade VEGFA-VEGFR2 Pathway Activated TLR4 signalling IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling ERK activation RAF phosphorylates MEK Downstream signaling of activated FGFR TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Signaling by Insulin receptor Innate Immune System Signalling by NGF Signal transduction by L1 Insulin receptor signalling cascade SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane SHC-related events MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer ERK2 activation Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) ERK2 activation
Drugs			Adenosine triphosphate
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ARAF BRAF CASP9 CCNDBP1 CNKSR1 COPS5 DUSP3 FAM65B GRIN1 GRIN2D LAMTOR3 LIG4 MAPK1 MAPK3 MAPK8 RAF1 RGS12 ZNF207	38 interactors: AGTRAP ASS1 BAD CHD6 COPS3 CPS1 CSNK2B DIDO1 E2F6 EFEMP1 GNA12 HRAS IRAK2 IRF7 KLHL12 KRAS MAP2K1 MAP2K2 MLH1 MYO18A NELFCD NUDT14 PBK PDGFRB PIK3R1 PKM PRPF6 RABGGTB RGS12 RRAS RRAS2 TEKT4P2 TESK1 TIMM44 TIRAP WNK1 YWHAG YWHAZ
Entrez ID		5605	369
HPRD ID		03164	02405
Ensembl ID		ENSG00000126934	ENSG00000078061
Uniprot IDs		B3KS97 P36507	B4DV85 P10398 Q96II5
PDB IDs		1S9I 4H3Q	1WXM
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway MAPK Cascade Signal Transduction By Phosphorylation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Cellular Response To Growth Factor Stimulus Fibroblast Growth Factor Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Response To Growth Factor Activation Of MAPKK Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Intracellular Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Toll-like Receptor 4 Signaling Pathway Response To Abiotic Stimulus Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Toll-like Receptor Signaling Pathway Fc Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Golgi Inheritance Response To Metal Ion Cellular Response To Inorganic Substance Activation Of Innate Immune Response Regulation Of Cellular Protein Metabolic Process Regulation Of MAPK Cascade Caveolin-mediated Endocytosis Positive Regulation Of Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Innate Immune Response Regulation Of Protein Metabolic Process	Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune Response-regulating Signaling Pathway Cellular Response To Stimulus Regulation Of Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Cellular Response To Peptide Hormone Stimulus Innate Immune Response Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Motility Regulation Of Signal Transduction Cellular Response To Peptide Cellular Response To Organonitrogen Compound Immune Response Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurotrophin Signaling Pathway Regulation Of Locomotion Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Component Movement Signaling Response To Hormone Regulation Of Signaling Cell Communication Toll-like Receptor 4 Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Hormone Stimulus Regulation Of Cell Migration Phosphorylation Response To Stimulus Regulation Of MAPK Cascade Response To Oleic Acid Intrinsic Apoptotic Signaling Pathway Response To Peptide Hormone Defense Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Response To Peptide Positive Regulation Of Cell Motility Toll-like Receptor Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Movement Positive Regulation Of MAP Kinase Activity Cellular Response To Insulin Stimulus
Tagcloud ?		acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting mapk10 mylk oxphos pak3 pathoetiology plcb1 pxn skew sos1 unacclimatized vasoconstriction vcam1	al augmentation braf craf1 die differentiated disruption dramatically drosophila elegans embryos enlarged establish failed finding gestation interacts mek membranes mid mutagenesis programmed ras signalling unlike unpublished vessels w
Tagcloud (Difference) ?		acclimatized adra1d altitude argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting mapk10 mylk oxphos pak3 pathoetiology plcb1 pxn skew sos1 unacclimatized vasoconstriction vcam1	al augmentation braf craf1 die differentiated disruption dramatically drosophila elegans embryos enlarged establish failed finding gestation interacts mek membranes mid mutagenesis programmed ras signalling unlike unpublished vessels w
Tagcloud (Intersection) ?		araf