MIF and NGFRAP1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MIF	NGFRAP1
Gene Name		macrophage migration inhibitory factor (glycosylation-inhibiting factor)	nerve growth factor receptor (TNFRSF16) associated protein 1
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Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Cell Surface Vesicle Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol
	Molecular Function	Dopachrome Isomerase Activity Receptor Binding Cytokine Activity Cytokine Receptor Binding Protein Binding Chemoattractant Activity Phenylpyruvate Tautomerase Activity	Death Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Metal Ion Binding
	Biological Process	Prostaglandin Biosynthetic Process Negative Regulation Of Mature B Cell Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Cell Aging Cell Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Protein Kinase A Signaling Carboxylic Acid Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of B Cell Proliferation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Innate Immune Response Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cytokine Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Prostaglandin Secretion Involved In Immune Response Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Protein Homotrimerization Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Cycle Arrest Positive Regulation Of Arachidonic Acid Secretion Negative Regulation Of Cell Aging Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Multicellular Organismal Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Apoptotic Signaling Pathway
Pathways			Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling NADE modulates death signalling
Drugs		3,4-Dihydroxycinnamic Acid 7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl Ester Citric Acid 3-(4-HYDROXY-PHENYL)PYRUVIC ACID 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)
Protein-Protein Interactions		12 interactors: BNIPL CD74 COPS5 COPS6 GORASP2 NGFRAP1 NME1 STRN4 TP53 UPF2 WDYHV1 ZNF408	28 interactors: AIMP2 CACYBP CCDC116 CCDC85B CTNNBL1 DIABLO EMILIN1 FSD2 GOLGA8EP GOLGA8F MIF MNAT1 NECAB2 NGFR NTRK3 PTPN13 SIVA1 SMPD1 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TSC1 USHBP1 VTA1 YWHAE
Entrez ID		4282	27018
HPRD ID		01091	02291
Ensembl ID			ENSG00000166681
Uniprot IDs		I4AY87 P14174	Q00994
PDB IDs		1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S 3L5T 3L5U 3L5V 3SMB 3SMC 3U18 4ETG 4EUI 4EVG 4F2K 4GRN 4GRO 4GRP 4GRQ 4GRR 4GRU 4GUM	1SA6
Enriched GO Terms of Interacting Partners?		Cullin Deneddylation Protein Deneddylation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Lymphocyte Apoptotic Process T Cell Differentiation In Thymus Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Regulation Of Fibroblast Proliferation	Regulation Of Cell Death Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Metabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process NIK/NF-kappaB Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Regulation Of Cellular Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Immune Response Cellular Response To Stimulus Regulation Of MAPK Cascade Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Cell Death TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Signaling Pathway Response To Organic Substance MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity
Tagcloud ?		analyzing anterior antiparasitic antiserum autocrine blocked completely counter deactivating demonstrating dihydrochloride endogenously exhibits glucocorticoid hypersensitivity iminoethyl inos kill knockout leishmania mab macrophage macrophages n6 nodes pituitary proinflammatory requirement tnf	abcf2 adprtl1 amy2b arhgap4 atp6ap1 axin1 casp4 cox1 cox7b ctsl etv4 lgals3bp mgc35136 mgc5528 mt2a mt3 p53scv ppia prdx2 psap scgb2a2 smoc2 sptan1 sra1 tax1bp1 tpd52l1 tra1 trf4 tuba4
Tagcloud (Difference) ?		analyzing anterior antiparasitic antiserum autocrine blocked completely counter deactivating demonstrating dihydrochloride endogenously exhibits glucocorticoid hypersensitivity iminoethyl inos kill knockout leishmania mab macrophage macrophages n6 nodes pituitary proinflammatory requirement tnf	abcf2 adprtl1 amy2b arhgap4 atp6ap1 axin1 casp4 cox1 cox7b ctsl etv4 lgals3bp mgc35136 mgc5528 mt2a mt3 p53scv ppia prdx2 psap scgb2a2 smoc2 sptan1 sra1 tax1bp1 tpd52l1 tra1 trf4 tuba4
Tagcloud (Intersection) ?