MIF and ZNF408

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		MIF	ZNF408
Description		macrophage migration inhibitory factor	zinc finger protein 408
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Surface Vesicle Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus
	Molecular Function	Protease Binding Dopachrome Isomerase Activity Cytokine Activity Cytokine Receptor Binding Protein Binding Isomerase Activity Chemoattractant Activity Identical Protein Binding Phenylpyruvate Tautomerase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Prostaglandin Biosynthetic Process Positive Regulation Of Cytokine Production Immune System Process Negative Regulation Of Mature B Cell Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Macrophage Chemotaxis Carboxylic Acid Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Cell Population Proliferation Positive Regulation Of Phosphorylation Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Innate Immune Response Positive Regulation Of Fibroblast Proliferation Positive Chemotaxis Negative Regulation Of Protein Metabolic Process Positive Regulation Of Prostaglandin Secretion Involved In Immune Response Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Protein Homotrimerization Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cellular Response To Stress Positive Regulation Of Arachidonate Secretion Cellular Senescence Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Cellular Senescence	Regulation Of Transcription By RNA Polymerase II
Pathways		Cell surface interactions at the vascular wall Neutrophil degranulation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		3,4-Dihydroxycinnamic Acid 7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl Ester 4-Hydroxyphenylpyruvic acid 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Macrophage Migration Inhibitory Factor levels ( 27989323) Serum alkaline phosphatase levels ( 33547301)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Femoral neck bone mineral density ( 29499414) Schizophrenia ( 29483656)
Interacting Genes		15 interacting genes: BEX3 BNIPL CD74 CEBPA COPS5 COPS6 EGFR EXOSC7 GORASP2 NME1 NTAQ1 STRN4 TP53 UPF2 ZNF408	83 interacting genes: AEBP2 AEN APOBEC3C ATRN BAHD1 CALCOCO2 CCDC136 CEP70 CHAF1A CRELD1 CYSRT1 DDX56 DVL3 EXOSC2 FBLN2 FHL2 FHL5 FSD2 GIPC1 GPATCH2L HNRNPK HOXA5 HOXB9 ID3 KCTD9 KHDRBS3 KRT40 KRTAP1-1 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP12-3 KRTAP4-12 KRTAP5-9 LDOC1 LSM2 LZTS2 MDFI MID2 MIF MRRF MTUS2 NBPF19 NOTCH2NLA PDE4DIP PDLIM4 PICK1 PNMA2 PRAME PRNP PRPF31 PSTPIP1 RALY RALYL RBM10 RBMY1F RBMY1J SAP30BP SPRED1 SSX2IP THAP1 TLE5 TOP3B TRIM23 TRIM41 UBE2I UPF2 USP20 ZBTB26 ZBTB48 ZBTB8A ZBTB9 ZC4H2 ZNF212 ZNF317 ZNF330 ZNF331 ZNF473 ZNF526 ZNF764 ZNF792 ZNF837 ZRANB1
Entrez ID		4282	79797
HPRD ID		01091	18338
Ensembl ID		ENSG00000240972	ENSG00000175213
Uniprot IDs		I4AY87 P14174	B4DXY4 Q9H9D4
PDB IDs		1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S 3L5T 3L5U 3L5V 3SMB 3SMC 3U18 3WNR 3WNS 3WNT 4ETG 4EUI 4EVG 4F2K 4GRN 4GRO 4GRP 4GRQ 4GRR 4GRU 4GUM 4K9G 4OSF 4OYQ 4P01 4P0H 4PKK 4PKZ 4PLU 4TRF 4TRU 4WR8 4WRB 4XX7 4XX8 4Z15 4Z1T 4Z1U 5B4O 5BS9 5BSC 5BSI 5BSJ 5EIZ 5HVS 5HVT 5HVV 5J7P 5J7Q 5UMJ 5UMK 5UZY 5V70 5V73 5XEJ 6B1C 6B1K 6B2C 6BG6 6BG7 6CB5 6CBF 6CBG 6CBH 6FVE 6FVH 6OY8 6OYB 6OYE 6OYG 6PEG 7E45 7E47 7E49 7E4A 7E4B 7E4C 7KQX 7XTX 7XVX 8CA0 8IMR 8SON 8SPN 8TT9 9BNQ 9BNR
Enriched GO Terms of Interacting Partners?		Macrophage Migration Inhibitory Factor Binding Identical Protein Binding T Cell Activation Involved In Immune Response Protein Deneddylation Metal-dependent Deubiquitinase Activity Regulation Of Fibroblast Proliferation Regulation Of Protein Neddylation Protein Neddylation Regulation Of Fatty Acid Biosynthetic Process Cytokine-mediated Signaling Pathway MHC Class II Protein Binding, Via Antigen Binding Groove Lymphocyte Activation Involved In Immune Response NOS2-CD74 Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Macrophage Migration Inhibitory Factor Signaling Pathway Cell Activation Involved In Immune Response Regulation Of Protein Modification Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Protein Metabolic Process Antigen Processing And Presentation Of Exogenous Antigen Leukocyte Activation Involved In Immune Response B Cell Mediated Immunity Protein-containing Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immunoglobulin Mediated Immune Response Negative Regulation Of Stem Cell Proliferation Embryonic Organ Development Embryonic Placenta Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Multivesicular Body, Internal Vesicle Lumen Leukocyte Apoptotic Process IgE Receptor Activity Farnesyl Diphosphate Kinase Activity Succinyl-CoA Binding Protein Phosphatase 2A Binding Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition COP9 Signalosome Protein-N-terminal Glutamine Amidohydrolase Activity Nucleus Negative Regulation Of Apoptotic Process Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Fibroblast Proliferation Regulation Of Lymphocyte Apoptotic Process Protein Complex Oligomerization Regulation Of Apoptotic Process	Identical Protein Binding Nucleus Protein Binding Zinc Ion Binding Intermediate Filament Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Keratin Filament Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Spliceosomal Complex MRNA Processing Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of MRNA Processing Regulation Of Primary Metabolic Process RNA Processing Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Muramyl Dipeptide
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