MIF and ZNF408

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		MIF	ZNF408
Gene Name		macrophage migration inhibitory factor (glycosylation-inhibiting factor)	zinc finger protein 408
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Cell Surface Vesicle Extracellular Vesicular Exosome	Nucleus
	Molecular Function	Dopachrome Isomerase Activity Receptor Binding Cytokine Activity Cytokine Receptor Binding Protein Binding Chemoattractant Activity Phenylpyruvate Tautomerase Activity	DNA Binding Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Prostaglandin Biosynthetic Process Negative Regulation Of Mature B Cell Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Cell Aging Cell Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Protein Kinase A Signaling Carboxylic Acid Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of B Cell Proliferation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Innate Immune Response Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cytokine Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Prostaglandin Secretion Involved In Immune Response Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Protein Homotrimerization Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Cycle Arrest Positive Regulation Of Arachidonic Acid Secretion Negative Regulation Of Cell Aging Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways
Drugs		3,4-Dihydroxycinnamic Acid 7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl Ester Citric Acid 3-(4-HYDROXY-PHENYL)PYRUVIC ACID 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)
Protein-Protein Interactions		12 interactors: BNIPL CD74 COPS5 COPS6 GORASP2 NGFRAP1 NME1 STRN4 TP53 UPF2 WDYHV1 ZNF408	37 interactors: ATRN CALCOCO2 CCDC136 CEP70 CHAF1A CRELD1 DDX56 DVL3 EXOSC2 FBLN2 FHL2 GIPC1 GPATCH2L HOXA5 HOXB9 ID3 KHDRBS3 KRTAP4-12 LDOC1 LSM2 MDFI MIF PDE4DIP PDLIM4 PRAME PRNP RALYL SAP30BP THAP1 TOP3B UPF2 ZBTB8A ZBTB9 ZNF212 ZNF330 ZNF331 ZNF792
Entrez ID		4282	79797
HPRD ID		01091	18338
Ensembl ID			ENSG00000175213
Uniprot IDs		I4AY87 P14174	B4DXY4 Q9H9D4
PDB IDs		1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S 3L5T 3L5U 3L5V 3SMB 3SMC 3U18 4ETG 4EUI 4EVG 4F2K 4GRN 4GRO 4GRP 4GRQ 4GRR 4GRU 4GUM
Enriched GO Terms of Interacting Partners?		Cullin Deneddylation Protein Deneddylation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Lymphocyte Apoptotic Process T Cell Differentiation In Thymus Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Regulation Of Fibroblast Proliferation	RNA Metabolic Process Gene Expression Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Heterocycle Metabolic Process Regulation Of Transcription, DNA-templated Cellular Aromatic Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Regulation Of Metabolic Process Cardiac Chamber Development Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Embryonic Skeletal System Development Positive Regulation Of Prostaglandin Secretion Involved In Immune Response RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Mesenchyme Development Positive Regulation Of MAP Kinase Activity Nuclear Polyadenylation-dependent TRNA Catabolic Process Preantral Ovarian Follicle Growth Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Regulation Of Cell Death Embryonic Organ Development Organ Development Positive Regulation Of JUN Kinase Activity Atrial Cardiac Muscle Cell Development Cell-cell Signaling Involved In Mammary Gland Development TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Heart Development Regulation Of JUN Kinase Activity Cardiac Septum Development Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Bronchiole Development Lung Goblet Cell Differentiation
Tagcloud ?		analyzing anterior antiparasitic antiserum autocrine blocked completely counter deactivating demonstrating dihydrochloride endogenously exhibits glucocorticoid hypersensitivity iminoethyl inos kill knockout leishmania mab macrophage macrophages n6 nodes pituitary proinflammatory requirement tnf
Tagcloud (Difference) ?		analyzing anterior antiparasitic antiserum autocrine blocked completely counter deactivating demonstrating dihydrochloride endogenously exhibits glucocorticoid hypersensitivity iminoethyl inos kill knockout leishmania mab macrophage macrophages n6 nodes pituitary proinflammatory requirement tnf
Tagcloud (Intersection) ?