MIF and WDYHV1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MIF	WDYHV1
Gene Name		macrophage migration inhibitory factor (glycosylation-inhibiting factor)	WDYHV motif containing 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Cell Surface Vesicle Extracellular Vesicular Exosome	Nucleus Cytosol
	Molecular Function	Dopachrome Isomerase Activity Receptor Binding Cytokine Activity Cytokine Receptor Binding Protein Binding Chemoattractant Activity Phenylpyruvate Tautomerase Activity	Protein Binding Protein-N-terminal Glutamine Amidohydrolase Activity
	Biological Process	Prostaglandin Biosynthetic Process Negative Regulation Of Mature B Cell Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Cell Aging Cell Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Protein Kinase A Signaling Carboxylic Acid Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of B Cell Proliferation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Innate Immune Response Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cytokine Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Prostaglandin Secretion Involved In Immune Response Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Protein Homotrimerization Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Cycle Arrest Positive Regulation Of Arachidonic Acid Secretion Negative Regulation Of Cell Aging Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Cellular Protein Modification Process
Pathways
Drugs		3,4-Dihydroxycinnamic Acid 7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl Ester Citric Acid 3-(4-HYDROXY-PHENYL)PYRUVIC ACID 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)
Protein-Protein Interactions		12 interactors: BNIPL CD74 COPS5 COPS6 GORASP2 NGFRAP1 NME1 STRN4 TP53 UPF2 WDYHV1 ZNF408	88 interactors: ACTB ACTG1 AMOT AMOTL2 APIP ASL BIRC2 BLMH BLOC1S6 C1orf50 CAPN3 CBFA2T2 CCDC102B CCDC184 CDA CDR2 COIL CRYAA CTH DAB1 DCTPP1 DHPS EDARADD EIF2B1 ETV6 FTH1 GAS7 GMDS GNMT GOLGA2 HPRT1 HSD17B14 JUP KCNH1 KCTD1 KLHL12 KRT31 KRTAP10-5 KRTAP10-7 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 LONRF1 LZTFL1 LZTS2 MAGEA11 MARCH10 MDFI MIF MTUS2 NCOA5 NECAB2 NME1 NPL NT5C1A NUDT14 PCBD1 PNMA1 PNMA5 PPCDC PRMT1 PRPS2 PTS PYGM RABAC1 RAD54L RBBP8 RBPMS RPIA SEPT3 SFN SIAH1 SMN1 STX11 THAP1 TMEM239 TNR TOLLIP TRIM27 TRIM54 TRIP13 TSC22D1 VAC14 VCP XIAP ZBTB8A ZNF341
Entrez ID		4282	55093
HPRD ID		01091	07653
Ensembl ID			ENSG00000156795
Uniprot IDs		I4AY87 P14174	Q96HA8
PDB IDs		1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S 3L5T 3L5U 3L5V 3SMB 3SMC 3U18 4ETG 4EUI 4EVG 4F2K 4GRN 4GRO 4GRP 4GRQ 4GRR 4GRU 4GUM	3C9Q
Enriched GO Terms of Interacting Partners?		Cullin Deneddylation Protein Deneddylation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Lymphocyte Apoptotic Process T Cell Differentiation In Thymus Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Regulation Of Fibroblast Proliferation	Protein Oligomerization Protein Complex Assembly Protein Homooligomerization Cellular Component Assembly Protein Homotetramerization Protein Tetramerization Nucleobase-containing Small Molecule Metabolic Process Nucleoside Metabolic Process Catabolic Process Cellular Nitrogen Compound Metabolic Process Purine Nucleoside Metabolic Process Anatomical Structure Development Small Molecule Metabolic Process Developmental Process Biosynthetic Process Cell Differentiation Nitrogen Compound Metabolic Process Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Cellular Metabolic Process Purine Nucleoside Monophosphate Catabolic Process Regulation Of Cell Death Tetrahydrobiopterin Biosynthetic Process Cell Development Nucleotide Metabolic Process System Development Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Ubiquitination Sulfur Amino Acid Metabolic Process Multicellular Organismal Development Aromatic Compound Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Modification By Small Protein Conjugation Cofactor Metabolic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Neuron Projection Development Regulation Of Metabolic Process Organophosphate Metabolic Process Cellular Modified Amino Acid Metabolic Process Regulation Of Cellular Localization Membrane Organization Response To Stimulus Organophosphate Catabolic Process Double-strand Break Repair Cellular Process S-adenosylmethionine Metabolic Process Pyrimidine Nucleoside Metabolic Process
Tagcloud ?		analyzing anterior antiparasitic antiserum autocrine blocked completely counter deactivating demonstrating dihydrochloride endogenously exhibits glucocorticoid hypersensitivity iminoethyl inos kill knockout leishmania mab macrophage macrophages n6 nodes pituitary proinflammatory requirement tnf
Tagcloud (Difference) ?		analyzing anterior antiparasitic antiserum autocrine blocked completely counter deactivating demonstrating dihydrochloride endogenously exhibits glucocorticoid hypersensitivity iminoethyl inos kill knockout leishmania mab macrophage macrophages n6 nodes pituitary proinflammatory requirement tnf
Tagcloud (Intersection) ?