ERN1 and SYVN1

Number of citations of the paper that reports this interaction (PubMedID 18369366)
18

Data Source:
HPRD (in vivo)

		ERN1	SYVN1
Description		endoplasmic reticulum to nucleus signaling 1	synoviolin 1
Image
GO Annotations	Cellular Component	Nuclear Inner Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Protein-containing Complex Ire1 Complex AIP1-IRE1 Complex IRE1-TRAF2-ASK1 Complex IRE1-RACK1-PP2A Complex	Hrd1p Ubiquitin Ligase Complex Hrd1p Ubiquitin Ligase ERAD-L Complex Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Endomembrane System Membrane Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Catalytic Activity Endonuclease Activity RNA Endonuclease Activity RNA Nuclease Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Enzyme Binding Hsp70 Protein Binding Identical Protein Binding Protein Homodimerization Activity ADP Binding Metal Ion Binding Unfolded Protein Binding Hsp90 Protein Binding Protein Serine Kinase Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Unfolded Protein Binding Protein-folding Chaperone Binding ATPase Binding Ubiquitin Protein Ligase Activity DNA-binding Transcription Factor Binding Ubiquitin-specific Protease Binding
	Biological Process	Endothelial Cell Proliferation MRNA Processing RNA Catabolic Process MRNA Catabolic Process Protein Phosphorylation Apoptotic Process Response To Unfolded Protein Negative Regulation Of Gene Expression Regulation Of Macroautophagy Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of RNA Splicing Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Cellular Response To Vascular Endothelial Growth Factor Stimulus IRE1-mediated Unfolded Protein Response Positive Regulation Of JNK Cascade MRNA Splicing, Via Endonucleolytic Cleavage And Ligation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Glucose Stimulus Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Insulin Metabolic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Response To Endoplasmic Reticulum Stress	Immature B Cell Differentiation Negative Regulation Of T-helper 1 Type Immune Response Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Retrograde Protein Transport, ER To Cytosol ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Protein K48-linked Ubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Mannose Trimming
Pathways		IRE1alpha activates chaperones IRE1alpha activates chaperones	XBP1(S) activates chaperone genes Hedgehog ligand biogenesis Hh mutants are degraded by ERAD ER Quality Control Compartment (ERQC)
Drugs		N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine Fostamatinib
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver injury in anti-retroviral drug treated HIV ( 28388302)	Crohn's disease ( 32581322)
Interacting Genes		15 interacting genes: BAK1 BAX COPS5 HSP90AA1 HSPA5 MAP3K5 P4HB PSEN1 RNF10 SRPK2 STUB1 SYVN1 TAOK3 TNFRSF1A TRAF2	17 interacting genes: APP ATL1 ATN1 CLU ERN1 GPR37 SLC35F2 TP53 TRIM59 UBE2D2 UBE2D3 UBE2G1 UBE2J1 UBE2U UBE2Z USP15 USP7
Entrez ID		2081	84447
HPRD ID		04943	07618
Ensembl ID		ENSG00000178607	ENSG00000162298
Uniprot IDs		O75460	Q86TM6
PDB IDs		2HZ6 3P23 4U6R 4YZ9 4YZC 4YZD 4Z7G 4Z7H 5HGI 6HV0 6HX1 6SHC 6URC 6W39 6W3A 6W3B 6W3C 6W3E 6W3K 6XDB 6XDD 6XDF 7BMK 8UVL	6A3Z 8KES 8KET 8KEV
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress Cellular Response To Stress Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein-folding Chaperone Binding Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Intracellular Signal Transduction Regulation Of Cellular Response To Stress Positive Regulation Of Metabolic Process Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Intracellular Signal Transduction Protein Catabolic Process Regulation Of Signal Transduction BAK Complex B Cell Negative Selection Regulation Of Apoptotic Signaling Pathway Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Protein-containing Complex Assembly Cellular Response To Topologically Incorrect Protein Regulation Of Cell Communication Regulation Of Signaling Protein Modification Process Positive Regulation Of Protein Metabolic Process Post-embryonic Camera-type Eye Morphogenesis IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Intracellular Signaling Cassette Protein Metabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Apoptotic Process Apoptotic Process Involved In Blood Vessel Morphogenesis Regulation Of JNK Cascade Cell Death Programmed Cell Death Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Protein Modification Process Post-embryonic Eye Morphogenesis Positive Regulation Of Apoptotic Process Involved In Morphogenesis Chaperone-mediated Autophagy Tumor Necrosis Factor Binding	Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Protein Polyubiquitination Proteolysis Positive Regulation Of Amyloid Fibril Formation Ubiquitin Protein Ligase Binding Apoptotic Process Protein Metabolic Process Programmed Cell Death Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Endoplasmic Reticulum Protein-containing Complex Regulation Of Response To Endoplasmic Reticulum Stress Nucleotide Binding Transferase Activity Protein-folding Chaperone Binding Regulation Of Amyloid Fibril Formation Regulation Of Cellular Response To Stress K48-linked Deubiquitinase Activity Protein K48-linked Ubiquitination Ubiquitin-like Protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Regulation Of Amyloid-beta Clearance Modification-dependent Protein Catabolic Process Response To Stress Negative Regulation Of Signal Transduction Release Of Cytochrome C From Mitochondria ATP Binding Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator Molecular Function Activator Activity Deubiquitinase Activity Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Signaling Macromolecule Metabolic Process Negative Regulation Of Cell Communication Glial Cell Proliferation Central Nervous System Development Positive Regulation Of Apoptotic Signaling Pathway Microglial Cell Activation Regulation Of Proteolysis
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